Preventive Effects of Dietary Cabbage Acylated Anthocyanins on Paraquat-induced Oxidative Stress in Rats

Igarashi, Kiharu; Kimura, Yuriko; Takenaka, Asako

doi:10.1271/bbb.64.1600

Cited by 66 publications

(41 citation statements)

References 32 publications

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“…42 When oxidative stress was induced in rats by treatment with Paraquat, anthocyanins isolated from eggplant and red cabbage were able to provide some protection and reduced the oxidative damage as measured by several indices. 43,44 In human studies, anthocyanincontaining berry fruit incorporated into juice mixtures increased both antioxidant status (plasma TEAC) and reduced oxidative damage (plasma MDA). 45,46 In contrast, a study in which human subjects consumed 750, 1000 or 1500 mL of a blackcurrant/apple juice combination found no change in plasma antioxidant status, a decrease in plasma MDA, and increase in plasma protein oxidation.…”

Section: Discussionmentioning

confidence: 99%

Boysenberry and blackcurrant drinks increased the plasma antioxidant capacity in an elderly population but had little effect on other markers of oxidative stress

et al. 2007

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BACKGROUND: The consumption of fruit and vegetables promotes good health by protecting against various degenerative diseases. Even though the constituents responsible are not known, some evidence indicates that the antioxidant properties of fruit and vegetable phytochemicals are responsible. Previous studies have shown that blackcurrant and Boysenberry reduce oxidative stress using in vitro cell systems. The aim of this study was to determine if blackcurrant or Boysenberry drinks could improve measures of oxidative stress and inflammation in an elderly population with below-average memory abilities. The intervention parallel study was fully blinded with a placebo control.

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Section: Discussionmentioning

confidence: 99%

Boysenberry and blackcurrant drinks increased the plasma antioxidant capacity in an elderly population but had little effect on other markers of oxidative stress

et al. 2007

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“…It has been demonstrated that anthocyanins have the following physiological functions: atherogenic index-lowering effects of ruburobrassicin (cyanidin 3-sophoroside-5-monoglucoside) (Igarashi et al, 1990), serum cholesterol-lowering effect of nasunin from peel of eggplant (Kayamori & Igarashi, 1994), triacylglycerol-lowering effect of malvin (Igarashi & Inagaki, 1991), protective effects of dietary cyanidin 3-O-glucoside on liver ischemia-reperfusion injury (Tsuda et al, 1999b), promoting effect of anthocyanogen for regeneration of rhodopsin (Tronche et al, 1967), protective effect of cyanidin on oxidation of low density lipoprotein (Satue-Gracia et al, 1997), and preventive effects of nasunin and acylated anthocyanins from red cabbage on paraquat-induced oxidative stress in rats (Kimura et al, 1999;Igarashi et al, 2000). Anthocyanins are expected to have even more physiological functions which differ from those above.…”

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confidence: 99%

Protective Effects of Boysenberry Anthocyanins on Oxidative Stress in Diabetic Rats

Sugimoto

Igarashi

Kubo

et al. 2003

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The protective effects of major boysenberry anthocyanins (BoAnt) against oxidative stress were investigated in streptozotocin (STZ)-induced diabetic rats. Increases in the concentration of plasma thiobarbituric acid reactive substances (TBARS), and in the liver 8-hydroxy deoxyguanosine (8-OH dG)/deoxyguanosine (dG) ratio and also in the liver GSSG/GSH ratio, which were all observed in STZ-injected rats, were restored or tended to be restored to the level of the control rats when a diet with BoAnt was given to the diabetic animals. The susceptibility of the liver homogenate of the diabetic rats to the oxidation by AAPH was relieved when BoAnt was fed to them. These results suggested that BoAnt was effective in protecting the development of in vivo oxidation involved with diabetes.

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“…It suppressed the formation of thiobarbituric acid-reactive substances and spared reduced glutathione (Tsuda et al, 2000a). Acylated anthocyanins reduce oxidative stress in the rat model of paraquat-induced oxidative damage (Igarashi et al, 2000). Notably, anthocyanin-rich diets did not influence cholesterol or fatty acid patterns in the livers of rats.…”

Section: Antioxidant Activitymentioning

confidence: 95%

Flavonoids and Cardiovascular Disease

Gross

2004

Pharmaceutical Biology

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Diets high in flavonoids have long been associated with nutritional recommendations, a healthy lifestyle, and the prevention of chronic diseases. However, identification of specific beneficial effects from specific flavonoids and flavonoid-rich foods has been a challenging area, probably due to a nonessential or conditional role for flavonoids in human nutrition. Nonetheless, recent efforts in the area of high flavonoid-containing foods and cardiovascular disease have begun providing the first demonstrations of specific effects and mechanisms of action in well-controlled studies. The early studies have shown that flavonoids have several anti-atherosclerotic activities including anti-inflammatory, antioxidant, antiproliferative, antiplatelet, and provessel function activities. Cholesterol-lowering and antihypertensive effects of flavonoids have been studied and appear minimal in humans. The studies also demonstrate several possible mechanisms and pleiotropic effects of flavonoids that may be active in reduction in the risk of cardiovascular disease. Several subclasses of flavonoids may contribute toward the apparent beneficial effects and include flavones, flavonols, flavanones, catechins isoflavones, proanthocyanidins, and anthocyanidins. Further studies are necessary for confirmation of the beneficial effects, identification of dose-response relationships, and identification the most bioactive flavonoids.

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Preventive Effects of Dietary Cabbage Acylated Anthocyanins on Paraquat-induced Oxidative Stress in Rats

Cited by 66 publications

References 32 publications

Boysenberry and blackcurrant drinks increased the plasma antioxidant capacity in an elderly population but had little effect on other markers of oxidative stress

Boysenberry and blackcurrant drinks increased the plasma antioxidant capacity in an elderly population but had little effect on other markers of oxidative stress

Protective Effects of Boysenberry Anthocyanins on Oxidative Stress in Diabetic Rats

Flavonoids and Cardiovascular Disease

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