Preventive Effects of Collagen Peptide from Deer Sinew on Bone Loss in Ovariectomized Rats

Zhang, He; Dong, Ying; Qi, Bin; Liu, Li; Zhou, Guangxin; Bai, Xueyuan; Yang, Chunhui; Zhao, Deyu; Zhao, Yu

doi:10.1155/2014/627285

Cited by 18 publications

(17 citation statements)

References 39 publications

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“…After the treatment of DPs, these two biomechanical parameters were significantly elevated to the normal levels ( P < 0.05), which could be beneficial to prevent fractures. Collagen peptides from deer sinew (0.4 g/kg/day) were also reported to improve mechanical indicators and prevent bone loss in ovariectomized rats after 13 weeks of treatment (Zhang, Dong, et al., 2014). Whereas, collagen hydrolysates from gelatins (10 g/day) were proved to have no effect on bone metabolism in postmenopausal women for a period of 24 weeks (Cúneo, Costa‐Paiva, Pinto‐Neto, Morais, & Amaya‐Farfan, 2010).…”

Section: Resultsmentioning

confidence: 99%

Desalted duck egg white peptides promoted osteogenesis via wnt/β‐catenin signal pathway

Guo

Zhao

et al. 2020

Journal of Food Science

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Osteoporosis is a degenerative disease that threatens bone health of the elderly (especially postmenopausal women). Since osteoporosis is important to prevent, the aim of this study was to investigate the regulation of desalted duck egg white peptides (DPs) on osteoporosis. In this study, the effects of DPs on bone formation were evaluated using MC3T3‐E1 cells and ovariectomized (OVX) rats. DPs significantly enhanced the preosteoblasts proliferation, differentiation, and matrix mineralization via the upregulation of wnt3a expression, low‐density lipoprotein receptor‐related protein‐5 (LRP‐5), β‐catenin, runt‐related transcription factor 2 (Runx2), and osteoprotegerin (OPG) (P < 0.05). The intracellular calcium concentration was significantly elevated by DPs (P < 0.05), which is attributed to calcium influx and L‐type calcium channels. Additionally, OVX rat model experiment indicated that DPs (600 mg/kg bw) had a superior effect against bone loss induced by estrogen deficiency, as it significantly declined bone turnover markers, and significantly increased biomechanical parameters (P < 0.05). Mineralized bone surfaces and bone microstructure were also obviously improved by DPs treatment. Immunohistochemical analysis showed that receptor activator of nuclear factor κ B (RANK) expression of tibia in DPs group was significantly reduced compared with the model group (P < 0.05). Our results demonstrated that DPs could enhance preosteoblasts differentiation and antiosteoporosis via wnt/β‐catenin signal pathway and several key osteogenic transcription factors such as Runx2 and OPG. Practical Application High‐value utilization of salted duck egg white, a byproduct of food industry, is worthy of in‐depth study. Desalted duck egg white peptides (DPs) were proved to promote bone formation, which suggests the potentials of DPs as cofactors in osteoporosis prevention.

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Section: Resultsmentioning

confidence: 99%

Desalted duck egg white peptides promoted osteogenesis via wnt/β‐catenin signal pathway

Guo

Zhao

et al. 2020

Journal of Food Science

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“…Type I collagen play an important role in the formation of bone matrix. Several studies indicated that collagen‐derived hydrolysates or peptides promote osteoblast differentiation and improved BMD in OVX rats by stimulating ALP activity and expression of transcription factors such as Runx2 and osterix (Guillerminet et al, ; Kimira et al, ; Zhang et al, ).…”

Section: Food‐derived Bioactive Peptides: Production and Bone Health mentioning

confidence: 99%

Bone health-promoting bioactive peptides

Ahn

2018

J Food Biochem

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Bioactive peptides, derivatives of proteins, show versatile biological effects and represent potential health-promoting agents as functional food ingredients and/or nutraceuticals. Bone health depends on the balance between bone formation and resorption. When the balance is disrupted, bone diseases such as osteoporosis and fragility fractures may result. Accumulating evidence suggests that peptides derived from endogenous proteins and food proteins enhance bone health.This article reviews the literature on peptides exhibiting bone health-promoting effects. Possible biochemical mechanisms and production of these peptides are briefly discussed.

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“…In addition, isolation of collagen peptides from fish-scale waste renders their production both economically and environmentally friendly. Marine collagen peptides have been identified as having a wide variety of activities, including antimicrobial, anti-inflammatory, anti-ulcer, lipid-lowering, wound-healing and anti-skin-aging [9,10]. They have also been observed to affect glucose tolerance and insulin sensitivity in high fat-fed rats and to modulate immune functions [11,12].…”

Section: Introductionmentioning

confidence: 99%

Prevention of diet-induced obesity in rats by oral application of collagen fragments

Raksha¹,

Potalitsyn²,

Yurchenko³

et al. 2018

ARCH BIOL SCI BELGRA

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The aim of the present study was to determine whether orally applied collagen fragments (CFs) could affect the development of obesity in obese rats. To this end, experimental rats that were exposed to a high-calorie diet (HCD) for four weeks were randomly divided into two groups: HCD and HCD+CFs, with both groups continuing to receive the HCD. However, rats from the HCD+CFs group were also provided with CFs in a 0.05-M citrate buffer (pH 5.0) (1 g•kg-1 of body weight) by intragastric administration, every other day for the next six weeks. Selected parameters associated with obesity development and insulin resistance, as well as serum markers of oxidative stress and the cytokine profile were assessed at the end of the 10 th week. Supplementation with CFs resulted in a decrease in body weight and body mass index when compared to animals exposed to a HCD. The observed changes were assumed to be caused by a lower food intake and increased water intake by obese rats treated with CFs. Enhanced activity of superoxide dismutase (SOD), catalase (CAT) and decreased malondialdehyde (MDA) concentration were detected in the HCD+CF group of animals when compared to untreated HCD-fed rats. Administration of CFs also lowered the serum concentrations of the proinflammatory cytokines IL-1β and IL-12, whereas the concentration of the anti-inflammatory cytokine IL-10 was significantly increased and the concentration of cytokine IL-4 was near the control value. Decreased concentrations of fasting blood glucose, glycated hemoglobin (GHbA1c) and serum insulin and increased tolerance to glucose in the oral glucose tolerance test (OGTT) were observed in the HCD+CF group of animals when compared to rats in the HCD group. We concluded that CFs mediated a therapeutic effect on obesity development in rats exposed to a HCD by affecting pathways involved in obesity pathogenesis.

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Preventive Effects of Collagen Peptide from Deer Sinew on Bone Loss in Ovariectomized Rats

Cited by 18 publications

References 39 publications

Desalted duck egg white peptides promoted osteogenesis via wnt/β‐catenin signal pathway

Desalted duck egg white peptides promoted osteogenesis via wnt/β‐catenin signal pathway

Bone health-promoting bioactive peptides

Prevention of diet-induced obesity in rats by oral application of collagen fragments

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