Preventive Effects of 10-Day Supplementation With Saffron and Indomethacin on the Delayed-Onset Muscle Soreness

Meamarbashi, Abbas; Rajabi, Ali

doi:10.1097/jsm.0000000000000113

Cited by 28 publications

(31 citation statements)

References 52 publications

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“…Elevated levels of CK and LDH are indicators of infl ammation and pathological consequences of DOMS. Similarly, saffron exhibited a protection of CK and LDH elevation after an eccentric exercise (33). As the raise of antioxidant capacity after crocin supplementation is concerned, the fi ndings of the present study are supported by previous studies.…”

Section: Discussionsupporting

confidence: 90%

Saffron (its active constituent, crocin) supplementation attenuates lipid peroxidation and protects against tissue injury

Altınöz¹,

T²,

Öner³

et al. 2016

BLL

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The aim of the current study was to investigate the outcomes in a rat model of an acute swimming exercise induced oxidative stress in brain, kidney, liver, skeletal and cardiac muscles using supplementation with crocin. Rats were divided into the eight groups; Normal Control (NC: Untreated and did not swim), Crocin Control (CC: Received crocin and did not swim), Exercise-1 (E-1: Untreated and swam), Exercise-24 (E-24: Untreated and swam), Exercise-48 (E-48: Untreated and swam), Exercise+Crocin-1 (EC-1: Received crocin and swam), Exercise+Crocin-24 (EC-24: Received crocin and swam), Exercise+Crocin-48 (EC-48: Received crocin and swam). The malondialdehyde (MDA) and xanthine oxidase (XO) enzymes levels increased after swimming in untreated and crocin treated groups, but there was a lower increase in crocin treated groups. The highest MDA levels in all tissues were observed in E-1 compared to all other groups. There were signifi cant differences between control and exercise groups in MDA levels of tissues (p < 0.001). In contrast, there were signifi cant differences between control and exercise groups in glutathione (GSH) levels of tissues.In addition, the crocin supplementation signifi cantly increased GSH levels and decreased MDA and XO enzyme levels when compared to untreated exercise groups. Crocin can protect the tissues against exercise induced oxidative stress by enhancing antioxidant activity

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Section: Discussionsupporting

confidence: 90%

Saffron (its active constituent, crocin) supplementation attenuates lipid peroxidation and protects against tissue injury

Altınöz¹,

T²,

Öner³

et al. 2016

BLL

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show abstract

“…Saffron intake with a protective effect significantly suppressed the elevation of plasma CPK activity in the endurance trained rats. Similar to our results, Memarbashi et al showed that 10‐day supplementation with 300 mg/d of saffron dried powder significantly decreased CPK and LDH after eccentric exercise (Meamarbashi & Rajabi, ). Mehdizadeh et al showed that pre‐treatment of saffron, as a cardio‐protective spice, decreased LDH and CPK levels induced by isoproterenol myocardial injury in rats (Mehdizadeh, Parizadeh, Khooei, Mehri, & Hosseinzadeh, ).…”

Section: Discussionsupporting

confidence: 91%

Effect of saffron ( Crocus sativus L.) and endurance training on mitochondrial biogenesis, endurance capacity, inflammation, antioxidant, and metabolic biomarkers in Wistar rats

et al. 2019

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We aimed to evaluate the effect of saffron (Crocus Sativus L.) treatment on endurance capacity, mitochondrial biogenesis, inflammation, antioxidant, and metabolic biomarkers in Wistar rats. Forty male rats were allocated equally into four groups: Saffron, Exercise and Saffron, Exercise and Placebo, and Placebo. Endurance training was accomplished on a specified rodent motor‐driven treadmill. Running to fatigue test and also metabolic and molecular indices were measured after eight weeks of intervention. mtDNA copy number and NRF‐1 gene expression increased significantly in the Ex + S group compared to the exercised and control group (p < 0.05). Endurance capacity time increased in the Ex + S group compared to the Ex group (p < 0.05). Malondialdehyde, CPK, AST, and IL‐6 decreased and antioxidant parameters including Glutathione peroxidase and Glutathione increased in the Ex + S group compared to exercised rats (p < 0.01). Saffron enhanced mitochondrial biogenesis, decreased oxidative stress, inflammation, and modulated metabolic biomarkers in exercised rats. Practical applications The influence of potential nutrient factors on exercise performance has reached much attention in recent years. Athletes require an appropriate sport supplement to reimburse their fatigue and improve their resilience. Saffron (Crocus Sativus L.) is a well‐known spice in the food trade which is quite popular around the world by giving a desirable taste to food. In an experimental study, we showed that saffron extract treatment during endurance training could improve endurance capacity by modulating several metabolic and genomic factors. Therefore, by relying on the results of this study and the positive effects of saffron published in previous studies, saffron could be added to sport beverages and supplements to enhance an athlete's performance.

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“…Fortynine articles were fully reviewed; from the bibliography of these six, additional articles were selected and reviewed. Twenty articles were excluded because they did not assess the outcomes of interest, and data could not be extracted from the reported graphs, inadequate intervention; a total of 23 studies were included [17,18,[23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42] (Fig. 1).…”

Section: Resultsmentioning

confidence: 99%

“…The characteristics of the included studies are shown in Table 1. One crossover study could be included in the parallel-group analysis [28]; twelve studies compared ibuprofen to placebo [25-30, 32, 36, 39, 41-43], one study compared ibuprofen to low-dose (75 mg) aspirin [34], one study compared indomethacin to placebo [35] or no treatment [24], three studies compared aspirin to placebo [17,18,38], and one study compared flurbiprofen to placebo [40]. One study was conducted in postmenopausal women [29]; other studies included young healthy participants.…”

Section: Resultsmentioning

confidence: 99%

Effect of Non-Steroidal Anti-Inflammatory Drugs on Sport Performance Indices in Healthy People: a Meta-Analysis of Randomized Controlled Trials

et al. 2020

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Background: Non-steroidal anti-inflammatory drugs (NSAIDs) are medications that are frequently used by athletes. There may also be some abuse of these substances, although it is unclear whether NSAIDs in fact enhance performance. We performed a systematic review and meta-analysis to evaluate the effect of NSAIDs on sport performance indices. Methods: We selected randomized trials from the PubMed and Cochrane Library databases investigating the effects of NSAIDs on sport performance. Volunteers could be healthy adult men and women. Any NSAID, administered by any route, taken prior to any type of exercise, and for any duration could be used. The control intervention could be a placebo, an active substance, or no intervention. We included doubleblind, single-blind, and open-label studies. The primary outcome was the maximum performance in exercises as defined in each study. The secondary outcomes were the time until self-reported exhaustion and the self-reported pain. Results: Among 1631 records, we retained thirteen parallel-group and ten crossover studies, totaling 366 and 148 subjects, respectively. They were disparate regarding treatments, dose and duration, and the type of exercise. There was neither significant difference in the maximum performance between NSAIDs and control groups nor in the time until exhaustion nor in self-perceived pain. Conclusions: The existence of an ergogenic effect of NSAIDs on sport performance indices was unable to be concluded, since the level of evidence of the studies is low, the doses tested, and the exercises performed are very heterogeneous and far from those observed in real-life practices. More studies are required.

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Preventive Effects of 10-Day Supplementation With Saffron and Indomethacin on the Delayed-Onset Muscle Soreness

Abstract: The saffron can be used to prevent DOMS and alleviate the DOMS symptoms.

Cited by 28 publications

References 52 publications

Saffron (its active constituent, crocin) supplementation attenuates lipid peroxidation and protects against tissue injury

Saffron (its active constituent, crocin) supplementation attenuates lipid peroxidation and protects against tissue injury

Effect of saffron ( Crocus sativus L.) and endurance training on mitochondrial biogenesis, endurance capacity, inflammation, antioxidant, and metabolic biomarkers in Wistar rats

Effect of Non-Steroidal Anti-Inflammatory Drugs on Sport Performance Indices in Healthy People: a Meta-Analysis of Randomized Controlled Trials

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