Preventive Effect of the Korean Traditional Health Drink (Taemyeongcheong) on Acetaminophen-Induced Hepatic Damage in ICR Mice

Yi, Ruokun; Song, Jia‐Le; Lim, Yaung-Iee; Kim, Yong-Kyu; Park, Kun-Young

doi:10.3746/pnf.2015.20.1.52

Cited by 9 publications

(10 citation statements)

References 31 publications

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“…Drop in the level of oxidative enzymes as alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and lactate dehydrogenase (LDH), and elevation in the level of antioxidative enzymes as catalase, superoxide dismutase, glutathione peroxidase, and glutathione was observed. Decline in expression of hepatic mRNA levels of TNF-α, IL-1β, IL-6, COX-2, and iNOS genes were observed, which can be linked to the lower degree of lesions to liver tissue (Yi et al 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Salicornia: evaluating the halophytic extremophile as a food and a pharmaceutical candidate

Patel

2016

3 Biotech

119

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Food insecurity is a major issue in current scenario where a large section of mankind is at risk of insufficient diet. As food productivity has its limits, the prospecting of unutilized or underutilized flora as food candidates is collectively recognized as a sustainable option. In the past decade, a number of obscure plants have been identified to be rich in dietary components and deemed fit for integration into the food platter. This review discusses a candidate Salicornia, belonging to family Amaranthaceae. This halophyte has a broad geographical distribution, and phytochemical profiling has indicated its food relevance. An array of functional nutrients as fibers, polyphenols, and flavonoids have been detected in Salicornia. Though high salt, oxalate and saponin content in the plants are anti-nutrients, they can be removed to justify usage of Salicornia as a ‘sea vegetable’. Apart from culinary relevance, medicinal attributes like immunomodulatory, lipid-lowering, antiproliferative, osteoprotective, and hypoglycemic render this lesser-known marsh plant significant for phytochemical studies. This appraisal is expected to be useful towards further research and popularization of this extremophile halophyte.

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Section: Introductionmentioning

confidence: 99%

Salicornia: evaluating the halophytic extremophile as a food and a pharmaceutical candidate

Patel

2016

3 Biotech

119

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“…Cells were cultured in DMEM containing 10% Fetal Bovine Serum (FBS) and 100 units/mL of penicillin-streptomycin. Cells were cultured at 37°C with 5% CO 2 [22]. This experiment was approved by the Cha University Animal Ethics Committee (IACUC-170149).…”

Section: Ex Vivo Splenocytes Collection and Culturementioning

confidence: 99%

“…Taemyeongcheong (TMC) is a health functional beverage made using traditional methods in Korea, and it is commonly found in various foods and herbal ingredients. TMC inhibits the allergic effects induced by 48/80 [21] and acetaminophen-induced hepatic damage in vivo [22]. We already reported that TMC inhibited Th2 cytokines such as IL-1β, IL-6, and IL-10 as well as iNOS and COX-2 in LPS-induced RAW 264.7 cells [23].…”

Section: Introductionmentioning

confidence: 96%

<em>Ex Vivo Rumex Crispus</em> and <em>Cordyceps Sinensis</em> Mixture Regulates Immune Cells Responses to Pro-inflammatory Cytokines inC57BL/6 mice Splenocytes

Park¹,

Song²,

Lee³

et al. 2018

Preprint

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We investigated the efficacy of a Rumex crispus and Cordyceps sinensis mixture made using the Beopje (Korea traditional processing method to remove anti-nutrients and enhance phytochemicals) method to regulate immune cell responses toward nitric oxide (NO) production, pro-inflammatory cytokines, and inflammation related genes in mice splenocytes. The six experimental groups were as follows: control (control), Rc-Cs (Rumex crispus (Rc) and Cordyceps sinensis (Cs) mixture, 6:4), TMC (Taemyeongcheong, commercial healthy drink containing Rc-Cs), LPS (lipopolysaccharide), LPS+Rc-Cs, and LPS+TMC. The Rc-Cs mixture reduced nitric oxide (NO) production in LPS-induced splenocytes. Moreover, Rc-Cs enhanced production of the pro-inflammatory cytokines TNF-α, IFN-γ, IL-1β, and IL-6 compared to the control (no treatment). However, Rc-Cs inhibited production of pro-inflammatory cytokines in LPS-induced splenocytes. In addition, LPS+Rc-Cs also significantly suppressed mRNA expression of IL-1β and IL-6 compared to LPS treatment. Interestingly, Rc-Cs did not increase mRNA levels of iNOS and COX-2, which are inflammation related genes compared to the control, while LPS+Rc-Cs reduced mRNA levels of iNOS and COX-2 compared LPS alone (p < 0.05). TMC showed a similar pattern compared to Rc-Cs. Therefore, Rc-Cs treatment in splenocytes enhanced NO production and pro-inflammatory cytokines compared to the control, whereas Rc-Cs treatment in LPS-induced splenocytes reduced NO production, pro-inflammatory cytokines, and inflammation related genes. Thus, Rc-Cs regulated immune cells responses by increasing pro-inflammatory cytokines in splenocytes and reducing toxin (LPS)-induced inflammation. These results indicate that a Rumex crispus and Cordyceps sinensis mixture (Rc-Cs) and TMC containing Rc-Cs promote immune cells responses and anti-inflammatory activities.

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“…Taemyeongcheong (TMC) is a health functional beverage made using traditional methods in Korea, and is commonly found in various foods and herbal ingredients. TMC inhibits the allergic effects induced by 48/80 (22) and acetaminophen-induced hepatic damage in vivo (23). We have previously reported that TMC inhibited Th2 cytokines such as IL-1β, IL-6, and IL-10 as well as iNOS and COX-2 in LPS-induced RAW 264.7 cells (24).…”

Section: Introductionmentioning

confidence: 99%

Rumex crispus and Cordyceps militaris Mixture Ameliorates Production of Pro-Inflammatory Cytokines Induced by Lipopolysaccharide in C57BL/6 Mice Splenocytes

Park

Song

Kim

et al. 2018

pnf

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Rumex crispus (Rc) and Cordyceps militaris (Cm) mixture (Rc-Cm; AST2017-01) ameliorated production of proinflammatory cytokines, inflammation-related genes, and nitric oxide (NO) induced by lipopolysaccharide (LPS) in mouse splenocytes. Rc-Cm (6:4) and Taemyeongcheong (commercial healthy drink containing Rc-Cm) were co-administered along with LPS. Rc-Cm inhibited production of tumor necrosis factor α, interferon γ, interleukin (IL)-1β, and IL-6 in LPS-induced splenocytes. However, levels of inflammatory cytokines were elevated in the absence of LPS treatment. Rc-Cm significantly suppressed mRNA expression of IL-1β, IL-6, and the inflammation-related genes inducible NO synthase (iNOS) and cyclooxygenase 2 (COX-2), as well as NO production upon LPS co-treatment. Whereas Rc-Cm increased mRNA expression of IL-1β, and IL-6, but did not up-regulate expression of iNOS and COX-2, or increase NO production without LPS co-treatment. Therefore, treatment of Rc-Cm to LPS-induced splenocytes ameliorated induction of pro-inflammatory cytokines, inflammation-related genes, and NO production. In the absence of LPS, Rc-Cm treatment up-regulated pro-inflammatory cytokines but did not alter expression of the inflammation-related genes iNOS and COX-2 or NO production. These results indicate that the natural phytochemicals chrysophanol and cordycepin in Rc-Cm promote anti-inflammatory activities and immune cell responses.

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Preventive Effect of the Korean Traditional Health Drink (Taemyeongcheong) on Acetaminophen-Induced Hepatic Damage in ICR Mice

Cited by 9 publications

References 31 publications

Salicornia: evaluating the halophytic extremophile as a food and a pharmaceutical candidate

Salicornia: evaluating the halophytic extremophile as a food and a pharmaceutical candidate

<em>Ex Vivo Rumex Crispus</em> and <em>Cordyceps Sinensis</em> Mixture Regulates Immune Cells Responses to Pro-inflammatory Cytokines inC57BL/6 mice Splenocytes

Rumex crispus and Cordyceps militaris Mixture Ameliorates Production of Pro-Inflammatory Cytokines Induced by Lipopolysaccharide in C57BL/6 Mice Splenocytes

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