Preventive effect of rutin on lipids, lipoproteins, and ATPases in normal and isoproterenol‐induced myocardial infarction in rats

Abstract

The present study was designed to evaluate the preventive role of rutin on lipids, lipoproteins, and ATPases in normal and isoproterenol (ISO)-induced myocardial infarction in rats. Rutin (40 and 80 mg/kg) was orally administered to rats for a period of 42 days. After that period, isoproterenol (150 mg/kg) was injected subcutaneously to male wistar rats at an interval of 24 h for 2 days. The weight of heart and the concentrations of total cholesterol, triglycerides, and free fatty acids were increased significantly (p < 0.05), and the concentration of phospholipids was decreased significantly (p < 0.05) in the heart of ISO-treated rats. ISO-treated rats also showed a significant increase (p < 0.05) in the levels of total cholesterol, triglycerides, phospholipids, low-density lipoprotein cholesterol (LDL-C), and very low-density lipoprotein cholesterol (VLDL-C) with a significant decrease (p < 0.05) in high-density lipoprotein cholesterol (HDL-C) level in serum. The activities of sodium potassium dependent adenosine triphosphatase (Na(+)/K(+) ATPase) and magnesium-dependent adenosine triphosphatase (Mg(2+) ATPase) were decreased significantly (p < 0.05), and the activity of calcium-dependent adenosine triphosphatase (Ca(2+)ATPase) was increased significantly (p < 0.05) in the heart in ISO-treated rats. Pretreatment with rutin at doses of 40 or 80 mg/kg to ISO-treated rats showed a significant (p < 0.05) effect in all the parameters studied. Oral administration of rutin to normal rats did not show any significant effect. Thus, the results of our study show that pretreatment with rutin maintained the levels of lipids, lipoproteins, and ATPases in ISO-induced myocardial infarcted rats. The observed effects might be due to the antioxidant potential of rutin.

Comparative evaluation of HMG CoA reductase inhibitors in experimentally-induced myocardial necrosis: Biochemical, morphological and histological studies

“…This elevated lipid alters enzymatic permeability and increased lipid synthesis by cardiac cAMP (Stanely Mainzen Prince and Karthick, 2007). In the present study, fall in HDLcholesterol level and elevation of total cholesterol and LDL-cholesterol levels was observed and this results are in line with earlier reports (Kumar et al, 2011;Stanely Mainzen Prince and Karthick, 2007).…”

Direct administration of rutin does not protect against catecholamine cardiotoxicity

“…The outcomes of the present study are in a sharp discrepancy with those of two studies of Karthick and Stanely Mainzen Prince (Karthick and Stanely Mainzen Prince, 2006;Stanely Mainzen Prince and Karthick, 2007). In their experiments, animals were pretreated for 42 days with rutin using intragastric tube and then ISO in a dose of 150 mg kg −1 s.c. was administered once daily for 2 days.…”

“…Indeed, previous studies have suggested very promising effects of rutin on ISO-induced cardiac injury in rats. Rutin, administered orally for 42 days, significantly improved both changes in the levels of lipids, lipoproteins and activity of Ca 2+ -dependent Na + /K + ATPase (Stanely Mainzen Prince and Karthick, 2007) as well as it reduced lipid peroxidation and increased myocardial antioxidative defence (Karthick and Stanely Mainzen Prince, 2006). The observed effects have been attributed to the antioxidant potential of rutin.…”

Preventive effect of (−)epigallocatechin gallate on lipids, lipoproteins, and enzymes of lipid metabolism in isoproterenol‐induced myocardial infarction in rats

“…Thus, EGCG protected the myocardium against the deleterious effects of lipids in experimentally induced MI. Previous studies also showed that antioxidants such as rutin and naringin prevented the accumulation of lipids in ISO-treated rats [36,37].…”