Preventive effect of regional radiotherapy with phosphorus-32 glass microspheres in hepatocellular carcinoma recurrence after hepatectomy

Abstract

Preventive effect of regional radiotherapy with phosphorus-32 glass microspheres in hepatocellular carcinoma recurrence after hepatectomy. World

Dose Delivery Estimated by Bremsstrahlung Imaging and Partition Model Correlated with Response Following Intra-arterial Radioembolization with 32P-Glass Microspheres for the Treatment of Hepatocellular Carcinoma

“…Embolization alone is an effective treatment, but application of gel foam can be used to enforce treatment efficacy. 8 Therefore, when rich blood supplies were observed following infusion, 1×1-mm gel foam granules were used during the embolization. Six patients were embolized via hepatic segmental artery, nine Large mass diameter of a single tumor >5 cm, nodules diameter of a single tumor <5 cm, diffuse diameter of a single tumor <3 cm with multiple tumors, PR partial response, MR minor response, SD static disease, PD progressive disease a Tumor size is presented as a percentage of liver volume b Survival at the time of final follow-up is indicated in bold and italic font via the hepatic left or right artery, and ten via the hepatic proper artery.…”

“…2,3 This approach is particularly applicable to hepatic tumors, since the tumor blood supply is primarily derived from the hepatic artery, whereas normal liver tissue is predominantly supplied with blood through the portal vein. [4][5][6][7][8] A recent review concluded that radioembolization with 90-yttrium glass microspheres for the treatment of patients with advanced hepatocellular carcinoma resulted in significant antitumor effects and that this promising new approach for targeted radiation delivery could effectively ameliorate this malignancy. 9 Similar to external radiotherapy, the therapeutic response of patients receiving internal radiation is closely related to the absorption of radiation doses within the tumor.…”

“…16 32 P glass microsphere-mediated radioembolization was recently shown to suppress growth of human hepatocellular carcinoma xenografts implanted in nude mice 17 and to prevent hepatocellular carcinoma recurrence following hepatectomy in patients with massive hepatocellular carcinomas. 8 Here, we investigated a novel and effective method for treating patients with hepatocellular carcinoma using intraarterial 32 P-glass microspheres and chemoembolization. Using β-bremsstrahlung imaging of 32 P radiation and a partition model for assessing glass bead distribution, we estimated the radiation doses within tumor tissue, nontumor liver tissue, and non-tumor lung tissue during treatment and evaluated patient clinical outcomes and possible adverse treatment effects following combined radio-and chemoembolization.…”

“…Indeed, because 32 P-glass microspheres applied during intra-arterial infusion distribute inhomogeneously in the liver, absorbed radiation doses differ between tumor and non-tumor liver tissues. 8 Due to the limited availability of tools for evaluating the radiation dose-effect relationship, it was necessary to use absorbed radiation doses of all liver tissue when evaluating treatment efficacy, rather than differentiating between tumor versus non-tumor liver and lung tissues. 11,12 Using the partition method, 10 the percentage of radioactivity shunted to the lung and the tumor-to-normal liver tissue ratio (T/N) are obtained using technetium-99m-labeled macroaggregate albumin ( 99m Tc-MAA scan).…”

Comparison of the clonogenic survival of A549 non-small cell lung adenocarcinoma cells after irradiation with low-dose-rate beta particles and high-dose-rate X-rays

“…Initially, this radioisotope was mainly used for the therapy of bone pain and metastases, in ovarian cancer and for myeloproliferative diseases (Pattillo et al 1995;Berlin 2000;PanditTaskar et al 2004;Tennvall & Brans 2007). More recently, studies on the use of 32 P as colloid or microsphere for solid tumors were performed; they showed not only an improvement in the patient's quality of life, but also in their survival (Gao et al 2008;Wang et al 2008). However, 32 P was not used in RIT due to the difficulty of the radiolabeling.…”