Preventive effect of Coriandrum sativum (Chinese parsley) on localized lead deposition in ICR mice

Aga, Miho; Iwaki, Kanso; Ueda, Yuki; Ushio, Shimpei; Masaki, Naoya; Fukuda, Shigeharu; Kimoto, Tetsuo; Ikeda, Masao; Kurimoto, Masashi

doi:10.1016/s0378-8741(01)00299-9

Cited by 38 publications

(33 citation statements)

References 17 publications

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“…The treatment used for heavy metal intoxication has improved with time. Some studies in mice and rats intoxicated with different concentrations of lead and treated with C. sativum show very encouraging results chelation and reduction poisoning in these animal models (Aga et al, 2001;Velaga et al, 2014). However, we need to find a natural treatment less invasive and performs like chelating agents.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Chelating Effect of Methanolic Extract of Coriandrum Sativum and Its Fractions on Wistar Rats Poisoned With Lead Acetate

Téllez-López

Mora-Tovar

Ceniceros-Méndez

et al. 2017

Afr J Tradit Complement Altern Med

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Background: The rate of lead poisoning has decreased in recent years due to increased health control in industries that use this metal. However, it is still a public health problem worldwide. The use of various plants with chelating properties has been a topic of research today. In traditional medicine, it is said that Coriandrum sativum has chelating properties, but there is no scientific evidence to support this fact. The purpose of this research is to evaluate the chelating effect of methanol extract of coriander and its fractions on Wistar rats intoxicated with lead. Materials and Methods: In this research, male Wistar rats were poisoned with 50 mg/kg of lead acetate and treated with 50 mg/kg of methanol extract and its fractions. The extract and its fractions were administered to four treatment groups. Positive and negative controls were established. Hemoglobin, hematocrit and lead concentrations were analyzed; liver was evaluated histologically in control and treatment groups. Results: The methanol extract of coriander presented a LD 50 ˃1000 mg/dL. The group administered with the methanol extract showed significant difference in the levels of hemoglobin and hematocrit compared to the negative control group. Lead concentration in treatment groups showed a decrease compared to the positive control. Histological evaluation of tissue showed less damage in groups administered with methanolic extract and its fractions compared to the positive control which presented structural alterations. Conclusion: Coriander extracts protect liver and lower lead concentration in rats intoxicated with lead in contrast to the positive control group.

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Section: Introductionmentioning

confidence: 99%

Evaluation of the Chelating Effect of Methanolic Extract of Coriandrum Sativum and Its Fractions on Wistar Rats Poisoned With Lead Acetate

Téllez-López

Mora-Tovar

Ceniceros-Méndez

et al. 2017

Afr J Tradit Complement Altern Med

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“…It was shown that coriander extracts have phenolic compounds and flavonoids, suggesting that these compounds contribute to the antioxidative activity [9]. Coriander suppresses the deposition of lead by chelating the metal [10].…”

Section: Introductionmentioning

confidence: 99%

Dose-Dependent Effect of Coriander (Coriandrum Sativum L.) and Fennel (Foeniculum Vulgare M.) on Lead Nephrotoxicity in Rats

2016

International Journal of Research Studies in Biosciences

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“…In addition, urinary excretion of delta-aminolevulinic acid (ALA) which was known to increase with lead intake was significantly decreased after administration of Coriandrum sativum. The MeOH extract of Coriandrum sativum also reduced lead-induced inhibition of deltaaminolevulinic acid dehydratase (ALAD) activity in vitro [163].…”

Section: Detoxification Effectmentioning

confidence: 99%

A review on chemical constituents and pharmacological activities of Coriandrum sativum

Al-Snafi¹

2016

IOSRPHR

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Abstract:-The phytochemical screening of Coriandrum sativum showed that it contained essential oil, tannins, terpenoids, reducing sugars, alkaloids, phenolics, flavonoids, fatty acids, sterols and glycosides. It also contained high nutritional values including proteins, oils, carbohydrates, fibers and wide range of minerals, trace elements and vitamins. The previous pharmacological studies revealed that it possessed anxiolytic, antidepressant, sedative-hypnotic, anticonvulsant, memory enhancement, improvement of orofacial dyskinesia, neuroprotective, antibacterial, antifungal, anthelmintic, insecticidal, antioxidant, cardiovascular, hypolipidemic, anti-inflammatory, analgesic, antidiabetic, mutagenic, antimutagenic, anticancer, gastrointestinal, deodorizing, dermatological, diuretic, reproductive, hepatoprotective, detoxification and many other pharmacological effects. The current review was designed to give an overview on the chemical constituents and pharmacological effects of Coriandrum sativum.

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Preventive effect of Coriandrum sativum (Chinese parsley) on localized lead deposition in ICR mice

Cited by 38 publications

References 17 publications

Evaluation of the Chelating Effect of Methanolic Extract of Coriandrum Sativum and Its Fractions on Wistar Rats Poisoned With Lead Acetate

Evaluation of the Chelating Effect of Methanolic Extract of Coriandrum Sativum and Its Fractions on Wistar Rats Poisoned With Lead Acetate

Dose-Dependent Effect of Coriander (Coriandrum Sativum L.) and Fennel (Foeniculum Vulgare M.) on Lead Nephrotoxicity in Rats

A review on chemical constituents and pharmacological activities of Coriandrum sativum

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