Preventive effect of Bacillus mojavensis levan against carbon tetrachloride and cisplatin toxicity: in vivo study

Haddar, Anissa; Feriani, Anouar; Hamed, Mariem; Sila, Assaâd; Ellouz-Chaabouni, Semia

doi:10.1007/s11356-021-14147-3

Cited by 3 publications

(1 citation statement)

References 57 publications

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“…On the same hand, hypertriglyceridemia ascribed to the capability of CCL4 to transfer the acetate into hepatocytes (Weber et al, 2003) and hinder the action of lysosomal lipase enzyme (Marimuthu et al, 2013).The current study exposed elevation in the activity of transaminases after CCL4 administration and that was allied to hyperlipidemia which interferes with liver function and also out flow of liver cytosolic content into the circulation due to oxidative stress of CCL4 that lead to imbalance between antioxidant and prooxidant system (Xu et al, 2021). These results were in accordance with the previous findings reported by (Haddar et al, 2021). Further lipid peroxidation was raised because of covalent binding of CCL4 metabolites, CCL3• and CCL3OO•, to the protein in the liver cell causing destructive effects (Abbasi et al, 2021).…”

Section: Discussionsupporting

confidence: 92%

N-Acetyl cysteine alleviates carbon-tetrachloride induced acute liver injury in rats

Mansour

El‐Zeftawy

Aboubakr

et al. 2022

New Valley Veterinary Journal

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The liver is a vital organ that performs most of the body's metabolic and detoxifying functions. There are various exogenous and endogenous factors that might cause liver issues. Carbon tetrachloride (CCL4) is non-inflammable colorless organic compound and employed in a variety of industrial fields. N-acetylcysteine (NAC) is one of the prospective pharmaceutical candidates possesses multiple clinical applications. The purpose of this study is to determine whether NAC has a protective effect in cases of liver injury or not. Thirty male albino rats were involved in the study, which lasted one month. They were categorized into three groups: control, liver injury group (0.5 ml/kg rat body weight (Bwt) CCL4 administered orally twice a week), and protective group (150 mg/kg Bwt NAC supplied orally). Serum lipid and protein profiles and liver enzymes activities were evaluated. Antioxidant, oxidative stress, and anti-inflammatory parameters were also assessed. Additionally, hepatic tissue was subjected to a histopathological investigation. The biochemical and histopathological results revealed dramatic improvement of studied parameters in NAC protective group comparing to liver injury one. Hence, we can conclude that, NAC shown a great potential in attenuating liver injury induced by CCL4 via refinement tumor necrosis factor-alpha, interleukin-6 and reduced glutathione pathway.

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