Preventive Effect of Arctium lappa Polysaccharides on Acute Lung Injury through Anti-Inflammatory and Antioxidant Activities

Abstract

The objective of this study was to investigate the preventive effects of polysaccharides extracted from the roots of Arctium lappa (ALP) against acute lung injury (ALI) models induced by lipopolysaccharide (LPS). The polysaccharides were extracted and characterized, and their anti-inflammatory and antioxidant capacities were assessed. The findings demonstrated that ALP could mitigate the infiltration of inflammatory cells and reduce alveolar collapse in LPS-induced ALI in mice. The expression levels of the pro-inflammatory factor TNF-α decreased, while the anti-inflammatory factor IL-10 increased. Furthermore, the administration of ALP improved the activities of lung antioxidant enzymes, including SOD, GSH, and CAT, and lowered MDA levels. These results suggest that ALP exhibits a preventive effect on ALI and has potential as an alternative treatment for lung injury.

Antidiabetic Properties of the Root Extracts of Dandelion (Taraxacum officinale) and Burdock (Arctium lappa)

“…Inulin, a fructan-type polysaccharide carbohydrate, is known for its various health benefits such as improving nutritional values, protecting against oxidative stress, mitigating inflammation [43], and having glucose-lowering properties [44]. However, it is essential to note that inulin is not the only polysaccharide with antidiabetic properties [45,46]. There is also a study [47] where a novel polysaccharide with high antioxidant, antibacterial, and anticancer activities was isolated from dandelion.…”

Polysaccharides from Medicinal Plants: Bridging Ancestral Knowledge with Contemporary Science

“…Treating fever, dizziness, sore throats, infection and others are some of the described effects, without focusing on certain isolated products from the plant [46]. Lu et al [47], however, isolated heteropolysaccharides composed of glucose, arabinose, and galactose from the roots of Arctium lappa (ALP), and observed anti-inflammatory effects in lung models. Later, Xiang et al [48] tested the same extracted polysaccharides in an in vitro model of nasal ectomesenchymal stem cells (EMSCs) to prevent liver fibrosis by inhibiting the Wnt/β-Catenin pathway.…”