Arctium lappa L. polysaccharides enhanced the therapeutic effects of nasal ectomesenchymal stem cells against liver fibrosis by inhibiting the Wnt/β-catenin pathway

Xiang, Wen; Yin, Guoliang; Liu, Haoming; Wei, Jiayi; Yu, Xinghui; Xie, Yan; Zhang, Li; XueTang,; Jiang, Wentao; Lu, Naiyan

doi:10.1016/j.ijbiomac.2024.129670

Cited by 1 publication

(2 citation statements)

References 39 publications

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“…ALP-treated EMSCs did not lose stemness while enhancing their anti-inflammatory and paracrine activity. Non-conditioned EMSCs were already able to reduce the fibrotic activity of HSCs alone, but when submitted to the ALP pre-condition, the effects were more pronounced [48].…”

Section: Fibrosis and Hepatoprotectionmentioning

confidence: 96%

“…Lu et al [47], however, isolated heteropolysaccharides composed of glucose, arabinose, and galactose from the roots of Arctium lappa (ALP), and observed anti-inflammatory effects in lung models. Later, Xiang et al [48] tested the same extracted polysaccharides in an in vitro model of nasal ectomesenchymal stem cells (EMSCs) to prevent liver fibrosis by inhibiting the Wnt/β-Catenin pathway. EMSCs were exposed to the polysaccharides, and parameters such as antioxidant activity were measured.…”

Section: Fibrosis and Hepatoprotectionmentioning

confidence: 99%

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Polysaccharides from Medicinal Plants: Bridging Ancestral Knowledge with Contemporary Science

Pedrosa,

Fabi

2024

Plants

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Plants are a core part of cultural identity, as part of a diet, decorations, ceremonies, or as medicinal agents. Empirical knowledge regarding plants and their healing potential has existed worldwide for centuries. With the advance of science and technology, not only is the refinement of such sources or isolation of specific compounds possible, but these compounds can also be characterized based on their natural occurrence. Besides their importance for plant metabolism and structure, polysaccharides have been demonstrated to have substantial positive human health impacts on inflammation, metabolism, oxidative stress, and others. As an inherent part of plant cell walls, many polysaccharides from medicinal herbs, such as fructans, glucans, and pectins, have been extracted and analyzed for their structure and function. However, a review summarizing a significant portion of these studies was still unavailable. This review helps to fill the knowledge gap between polysaccharide bioactivity, their structure, and their plant matrix sources, focusing on historical medicinal usage.

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Section: Fibrosis and Hepatoprotectionmentioning

confidence: 96%

Section: Fibrosis and Hepatoprotectionmentioning

confidence: 99%