Preventive Effect and Molecular Mechanism of Lactobacillus rhamnosus JL1 on Food-Borne Obesity in Mice

Yang, Mo; Zheng, Jiapeng; Zong, Xinran; Yang, Xinyan; Man, Chaoxin; Jiang, Yujun

doi:10.3390/nu13113989

Cited by 24 publications

(20 citation statements)

References 45 publications

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“…Previous studies have shown that LPS-induced inflammation is one of the causes of pancreatic beta cell dysfunction [42], which also explains why the DM mice had the most severe inflammation and structural abnormalities of tissues. Liver steatosis in the DM group can be explained by the excess accumulation of these lipid metabolites [43].…”

Section: Discussionmentioning

confidence: 99%

A Potential Synbiotic Strategy for the Prevention of Type 2 Diabetes: Lactobacillus paracasei JY062 and Exopolysaccharide Isolated from Lactobacillus plantarum JY039

Zhao¹,

Wang²,

Cheng³

et al. 2022

Nutrients

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The disturbance of intestinal microorganisms and the exacerbation of type 2 diabetes (T2D) are mutually influenced. In this study, the effect of exopolysaccharides (EPS) from Lactobacillus plantarum JY039 on the adhesion of Lactobacillus paracasei JY062 was investigated, as well as their preventive efficacy against T2D. The results showed that the EPS isolated from L. plantarum JY039 effectively improved the adhesion rate of L. paracasei JY062 to Caco-2 cells (1.8 times) and promoted the proliferation of L. paracasei JY062. In the mice experiment, EPS, L. paracasei JY062 and their complex altered the structure of the intestinal microbiota, which elevated the proportion of Bifidobacterium, Faecalibaculum, while inversely decreasing the proportion of Firmicutes, Muribaculaceae, Lachnospiraceae and other bacteria involved in energy metabolism (p < 0.01; p < 0.05); enhanced the intestinal barrier function; promoted secretion of the gut hormone peptide YY (PYY) and glucagon-like peptide-1 (GLP-1); and reduced inflammation by balancing pro-inflammatory factors IL-6, TNF-α and anti-inflammatory factor IL-10 (p < 0.01; p < 0.05). These results illustrate that EPS and L. paracasei JY062 have the synbiotic potential to prevent and alleviate T2D.

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Section: Discussionmentioning

confidence: 99%

A Potential Synbiotic Strategy for the Prevention of Type 2 Diabetes: Lactobacillus paracasei JY062 and Exopolysaccharide Isolated from Lactobacillus plantarum JY039

Zhao¹,

Wang²,

Cheng³

et al. 2022

Nutrients

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“…LPS can penetrate through the intestinal epithelial cells and, after binding to chylomicrons, are transported to insulin-sensitive organs, causing insulin resistance and inflammation [ 72 ]. One of the main characteristics of type 2 diabetes is chronic inflammation; patients with this condition present excessive levels of inflammatory markers [ 73 ]. The levels of these pro-inflammatory elements were linked to those of LPS and free fatty aciyesds and are considered the important link between inflammation, obesity, insulin resistance, and type 2 diabetes.…”

Section: Use Of Probiotics For Pharmaceutical Propertiesmentioning

confidence: 99%

“…Diabetic mouse models have shown acute inflammation and structural abnormalities in their tissues. Fatty liver disease steatosis was also shown in the diabetic group due to the excessive accumulation of lipid metabolites [ 73 ].…”

Section: Use Of Probiotics For Pharmaceutical Propertiesmentioning

confidence: 99%

The Gut Microbiota Influenced by the Intake of Probiotics and Functional Foods with Prebiotics Can Sustain Wellness and Alleviate Certain Ailments like Gut-Inflammation and Colon-Cancer

Dahiya

Nigam

2022

Microorganisms

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The gut microbiota is composed of several microbial strains, with diverse and variable combinations in healthy and sick persons, changing at different stages of life. A healthy balance between host and gut microorganisms must be maintained in order to perform the normal physiological, metabolic, and immune functions and prevent disease development. Disturbances in the balance of the gut microbiota by diverse reasons initiate several health issues and promote the progression of certain diseases. This review is based on published research and reports that describe the role of probiotic microorganisms in the sustainability of health and the alleviation of certain diseases. Information is presented on the GRAS strains that are used as probiotics in the food industry for the production of fermented milk, yogurt, fermented food, functional foods, and probiotic drinks. To maintain a healthy microbiota, probiotic supplements in the form of freeze-dried live cells of probiotic strains are also available in different forms to consumers. The health benefits of lactic acid bacteria and other microorganisms and their role in the control of certain diseases such as gut inflammation, diabetes, and bowel cancer and in the safeguarding of the gut epithelial permeability from the invasion of pathogens are discussed.

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“…Acetic acid is a very important raw material for the synthesis of serum total cholesterol (TC) and participates in the hepatic circulation, thus regulating lipid metabolism disorders ( 73 ). Propionic acid inhibits the synthesis of TC.…”

Section: Key Mechanisms Involved In the Regulation Of Intestinal Micr...mentioning

confidence: 99%

The contribution of the gut-liver axis to the immune signaling pathway of NAFLD

Liu

Cai

et al. 2022

Front. Immunol.

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Nonalcoholic fatty liver disease (NAFLD) is the liver manifestation of metabolic syndrome and is the most common chronic liver disease in the world. The pathogenesis of NAFLD has not been fully clarified; it involves metabolic disturbances, inflammation, oxidative stress, and various forms of cell death. The “intestinal-liver axis” theory, developed in recent years, holds that there is a certain relationship between liver disease and the intestinal tract, and changes in intestinal flora are closely involved in the development of NAFLD. Many studies have found that the intestinal flora regulates the pathogenesis of NAFLD by affecting energy metabolism, inducing endotoxemia, producing endogenous ethanol, and regulating bile acid and choline metabolism. In this review, we highlighted the updated discoveries in intestinal flora dysregulation and their link to the pathogenesis mechanism of NAFLD and summarized potential treatments of NAFLD related to the gut microbiome.

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Preventive Effect and Molecular Mechanism of Lactobacillus rhamnosus JL1 on Food-Borne Obesity in Mice

Cited by 24 publications

References 45 publications

A Potential Synbiotic Strategy for the Prevention of Type 2 Diabetes: Lactobacillus paracasei JY062 and Exopolysaccharide Isolated from Lactobacillus plantarum JY039

A Potential Synbiotic Strategy for the Prevention of Type 2 Diabetes: Lactobacillus paracasei JY062 and Exopolysaccharide Isolated from Lactobacillus plantarum JY039

The Gut Microbiota Influenced by the Intake of Probiotics and Functional Foods with Prebiotics Can Sustain Wellness and Alleviate Certain Ailments like Gut-Inflammation and Colon-Cancer

The contribution of the gut-liver axis to the immune signaling pathway of NAFLD

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