Preventive and therapeutic effect of complex antioxidant preparation in rats with burn trauma

Mikhalchik, Elena V.; Иванова, А. В.; Anurov, M.; Titkova, S.; Penkov, L. Yu.; Korkina, Liudmila

doi:10.1007/bf02694176

Cited by 4 publications

(7 citation statements)

References 6 publications

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“…1). This parameter decreased after Immudzhen administration, which is consistent with the results of our previous experiments [2].…”

Section: Resultssupporting

confidence: 94%

“…Previous studies showed that burn trauma is followed by an imbalance in the antioxidant system of erythrocytes. These changes are related to the increase in SOD activity not accompanied by corresponding activation of peroxide-utilizing enzymes [2]. We showed that LPS increases the degree of this imbalance due to reduction of enzyme activity.…”

Section: Resultsmentioning

confidence: 95%

“…Injection of endotoxin increased MPO content in the lung tissue of burned animals by 7 times compared to normal. It should be emphasized that MPO content in rats with uncomplicated burn trauma exceeded the normal by 1.6 times [2]. In animals of both groups MPO content in the epidermis adjacent to the burn area increased 4 days after burn trauma (Fig.…”

Section: Resultsmentioning

confidence: 96%

“…The solution of E. coli O111:B4 endotoxin (Sigma) in a dose of 1 mg/kg was injected intraperitoneally on day 4 after burn trauma. Cell chemiluminescence was measured in whole venous blood [2]. The epidermis (10 mm from the zone of injury) was excised before treatment, on day 4 of the postburn period, and 24 h after endotoxin injection.…”

Section: Methodsmentioning

confidence: 99%

“…The lung tissue was sampled and treated routinely. The epidermis was homogenized as described elsewhere [2].…”

Section: Methodsmentioning

confidence: 99%

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Protective effect of complex antioxidant preparation containing vitamins and amino acids in rats with burn trauma complicated by endotoxemia

et al. 2006

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Burn trauma increased blood chemiluminescence, while lipopolysaccharide in a dose of 1 mg/kg potentiated this effect, activated LPO, and decreased plasma antioxidant activity. In erythrocytes, superoxide dismutase activity increased, while activity of peroxide-utilizing enzymes decreased. Myeloperoxidase content increased in the lungs and epidermis. The preparation of alpha-tocopherol, selenium aspartate, and ubiquinone abolished the effect of lipopolysaccharide, but did not modulate the increase in chemiluminescence under the influence of this agent.

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“…1). This parameter decreased after Immudzhen administration, which is consistent with the results of our previous experiments [2].…”

Section: Resultssupporting

confidence: 94%

Section: Resultsmentioning

confidence: 95%

Section: Resultsmentioning

confidence: 96%

Section: Methodsmentioning

confidence: 99%

“…The lung tissue was sampled and treated routinely. The epidermis was homogenized as described elsewhere [2].…”

Section: Methodsmentioning

confidence: 99%

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Protective effect of complex antioxidant preparation containing vitamins and amino acids in rats with burn trauma complicated by endotoxemia

et al. 2006

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Effect of delta sleep-inducing peptide on macromolecule biosynthesis in brain tissue of stressed rodents

Makletsova¹,

Mikhaleva

Прудченко

et al. 2006

Bull Exp Biol Med

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Indole-3-Carbinol Induction of CYP1A1, CYP1A2, and CYP3A1 Activity and Gene Expression in Rat Liver under Conditions of Different Fat Content in the Diet

et al. 2012

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Wistar male rats were fed semisynthetic diet with different fat content for 6 weeks: fat-free, 10%, and 30% fat (sunflower oil and lard, 1:1). Increasing fat content was associated with an increase in ethoxyresofurin-O-dealkylase (EROD) activity of CYP1A1, methoxyresofurin-O-dealkylase (MROD) activity of CYP1A2, and 6β-testosterone-hydroxylase (6β-TH) activity of CYP3A1. EROD, MROD, and 6β-TH activities in rats on high-fat diet exceeded those in rats on fat-free diet by 64, 58, and 140%, respectively. Addition of indole-3-carbinol to the diet led to an increase in CYP1A1, CYP1A2, and CYP3A1 activities and mRNA levels, the degree of this increase was lower with increasing fat content in the diet. In rats on fat-free, 10% fat, and 30% fat diets, indole-3-carbinol induced EROD activity by 4.7, 3.2, and 2.0 times, respectively; MROD activity by 5.9, 5.6, and 5.4 times; and 6β-TH activity by 2.1, 1.9, and 1.3 times. A correlation was detected between activities of the studied cytochrome P-450 isoforms, their inducibility by indole-3-carbinol, and vitamin A and E levels in rat liver.

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Preventive and therapeutic effect of complex antioxidant preparation in rats with burn trauma

Cited by 4 publications

References 6 publications

Protective effect of complex antioxidant preparation containing vitamins and amino acids in rats with burn trauma complicated by endotoxemia

Protective effect of complex antioxidant preparation containing vitamins and amino acids in rats with burn trauma complicated by endotoxemia

Effect of delta sleep-inducing peptide on macromolecule biosynthesis in brain tissue of stressed rodents

Indole-3-Carbinol Induction of CYP1A1, CYP1A2, and CYP3A1 Activity and Gene Expression in Rat Liver under Conditions of Different Fat Content in the Diet

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