Preventive and Protective Effect of Nishamalaki in STZ Induced Diabetic Complications in Wistar Rats

Dawane, Jayshree; Pandit, Vijaya; Deshpande, Swapnil S.; Mandpe, Amruta Sumedh

doi:10.7860/jcdr/2016/17940.7912

Cited by 2 publications

(3 citation statements)

References 17 publications

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“…The results showed a significant decrease in glucose compared to the control group [19]. This study is consistent with Venkateshwarlu et al (2013), where papaya contains flavonoids, tannins, and alkaloids that have a hypoglycemic effect [20]. In this study, compared to other studies, they both contain flavonoid compounds but differ in the solvent and maceration method.…”

Section: Discussionsupporting

confidence: 91%

Artocarpus altilis Extract Capsules Reduce Fasting Blood Glucose in Prediabetes

Sitorus

Hadju

Jafar

et al. 2022

Open Access Maced J Med Sci

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BACKGROUND: Management of prediabetes patients is essential to reduce the increased prevalence of type 2 diabetes. Prediabetes prevention strategies have been widely carried out with traditional medicine by the community. AIM: This study aims to assess the effect of Artocarpus altilis extract on reducing fasting blood glucose of the patients in Maros Regency, Indonesia. METHOD: The study was a double-blind, randomized controlled trial, dividing participants into intervention groups who received A. altilis extract (n = 37) and the control group who received placebo (n = 37). The assessment of fasting blood glucose through screening with a simple enzymatic method. A fasting blood glucose was then validated using the spectrophotometric method. The fasting blood glucose measurement was performed again after 28 days of intervention, besides physical activity, food intake, and education of prediabetes/diabetes prevention measurements. The A. altilis extract was developed after the cold maceration process using a freeze dryer at −60°C. The data were analyzed using chi-square, independent t-test, t-test, and Wilcoxon test. RESULTS: Most participants were female (68.0%), 40–49 years (51.9%), and stay-at-home parent (70.3%). The baseline data reports all variables were not significantly different between the two groups (p > 0.005). There was a significant decline in the intervention group after the intervention (114.89 ± 6.6 vs. 98.73 ± 4.8, p < 0.001) and no changes in the control group (113.62 ± 6.6 vs. 113.59 ± 6.7, p = 0.768). CONCLUSION: There is a significant reduction in fasting blood glucose in the intervention group who received A. altilis extract.

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Section: Discussionsupporting

confidence: 91%

Artocarpus altilis Extract Capsules Reduce Fasting Blood Glucose in Prediabetes

Sitorus

Hadju

Jafar

et al. 2022

Open Access Maced J Med Sci

View full text Add to dashboard Cite

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“…Curcuma and Emblica are individually shown to have protective value in diabetic nephropathy 5,6 . Our preliminary study has shown kidney protective action of Nishamalaki 4 . NA was included in this study to confirm this effect.…”

Section: Introductionmentioning

confidence: 65%

“…Nishamalaki is shown to have many actionsreducing hyperglycemia; reduction in aldose reductase; reduction in oxidative stress, etc. It has been shown to have a favorable effect of controlling DM and its ocular complications 4 . Curcuma and Emblica are individually shown to have protective value in diabetic nephropathy 5,6 .…”

Section: Introductionmentioning

confidence: 99%

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2019

IJPSR

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Type 2 diabetes, which is the most common type, is often a result of excess body weight and physical inactivity in genetically predisposed individuals. Over due course of time diabetes can cause blindness, kidney damage, neurological problems, and coronary artery disease. Improvement in glycemic control is important factors in delaying the onset and progression of diabetes-related complications. In spite of the availability of newer antidiabetic drugs, prevention of complication is still a challenge. Nishamalaki, Patoladi Yoga and Shobhanjan are the Ayurvedic formulations claimed to be effective in preventing nephrotoxicity. Objective: To evaluate the therapeutic efficacy of Nishamalaki, Patoladi Yoga, and Shobhanjan in diabetic nephropathy. Materials and Methods: Total of 36 Wistar rats were used for the study. Diabetes was induced in 30 Wistar rats of either sex with STZ (35 mg/kg) i.p followed by High Fat High Fructose diet (HFHF), (coconut oil+ vanaspati) till the development of Diabetic nephropathy (10wks) which was confirmed by Sr. creatinine, blood urea levels. Out of six groups included in the study, group I was without diabetes, Diabetic animals were divided into five groups Group II-Diabetic control, Group III-Nishamalaki, Group IV-Patoladi Yoga, Group V-Shobhanjan & Group VI-Enalapril and drug treatment was given according to groups orally for 45days. Blood sugar levels, BUN, creatinine were tested weekly. Results: Nishamalaki significantly (p<0.001) improved Creatinine level compared with the diabetic control group. Reduction in BUN values was more with Patoladi (p<0.001) than Shobhanjan (p<0.01). Results of Nishamalaki, Patoladi yoga, and Enalapril were comparable to the control group. Patoladi appeared significantly more effective in reducing BUN & Creatinine values than shobhanjan. Nishamalaki additionally showed a blood sugar lowering effect. Conclusion: Nishamalaki, Patoladi yoga has shown a protective effect against diabetic nephropathy. Both are effective in delaying the progression of nephropathy in diabetes mellitus.

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Preventive and Protective Effect of Nishamalaki in STZ Induced Diabetic Complications in Wistar Rats

Cited by 2 publications

References 17 publications

Artocarpus altilis Extract Capsules Reduce Fasting Blood Glucose in Prediabetes

Artocarpus altilis Extract Capsules Reduce Fasting Blood Glucose in Prediabetes

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