Prevention of Vascular Graft Infection by Rifampin Bonding to a Gelatin-Sealed Dacron Graft

Goëau-Brissonnière, Olivier; Leport, Catherine; Bacourt, F; Lebrault, C.; Comte, Raymonde; Pechère, J.-C.

doi:10.1007/bf02133043

Cited by 87 publications

(30 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The in vivo results were similar to those reported by other investigators (4,6,8,9,15,22,24,26), who found that the use of Dacron grafts soaked in an antibiotic can result in significant bacterial growth inhibition, even though high concentrations of organisms were topically inoculated on the Dacron prostheses. Actually, statistical analysis demonstrated that any prophylactic antibiotic treatment except vancomycin at 10 g/ml was useful.…”

Section: Discussionsupporting

confidence: 90%

See 1 more Smart Citation

Efficacy of Quinupristin-Dalfopristin in Preventing Vascular Graft Infection Due to Staphylococcus epidermidis with Intermediate Resistance to Glycopeptides

Giacometti¹,

Cirioni²,

Ghiselli

et al. 2002

Antimicrob Agents Chemother

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 90%

“…The centerpieces of prophylaxis are asepsis and perioperative administration of systemic antibiotics (3,5). As adjunctive prophylaxis, in the case of vascular grafts, the use of antimicrobials that bind to prosthetic grafts at high concentrations has been proposed (4,6,8,9,15,20,22,24,26).…”

mentioning

confidence: 99%

Efficacy of Quinupristin-Dalfopristin in Preventing Vascular Graft Infection Due to Staphylococcus epidermidis with Intermediate Resistance to Glycopeptides

Giacometti¹,

Cirioni²,

Ghiselli

et al. 2002

Antimicrob Agents Chemother

View full text Add to dashboard Cite

“…After the initial experimental report of the use of a rifampicin-bonded gelatin-sealed Dacron graft by Goëau-Brissonnière, et al 13) and the first clinical report of the use of a Table 1 Steps on how to prepare the complete rifampicin solution with a surfactant 1) Water for injection is taken in the clear sterilization pot with stirrer bar and warmed up. 2) A surfactant is added little by little and dissolved, followed by autoclaving steam sterilization at 115°C for 30 minutes.…”

Section: Discussionmentioning

confidence: 99%

A Case of In-Situ Reconstruction with a Rifampicin-Bonded Gelatin-Sealed Woven Dacron Graft for Prosthetic Graft Infection with Pseudoaneurysms after Ascending Aortic Replacement for Type A Dissection

Iida¹,

Ito²,

Kuwabara³

et al. 2014

Annals of Vascular Diseases

View full text Add to dashboard Cite

A 74-year-old woman underwent replacement of the ascending aorta for acute type A aortic dissection. The patient suffered from bacteremia postoperatively and repeated computed tomography showed an increasing diameter of pseudoaneurysms at the site of the proximal anastomosis due to graft infection. Re-mechanical Bentall operation and arch replacement were therefore performed using a composite graft of a rifampicinbonded gelatin-sealed 24-mm woven Dacron graft and a mechanical valve. The postoperative course was uneventful. We report the successful in situ reconstruction using the above-mentioned Dacron graft and describe the preparation of the rifampicin solution using a surfactant.

show abstract

“…The centerpiece of therapy is prophylactic systemic antibiotics (3,7). In addition, in the case of vascular grafts, antimicrobials, such as rifampin, bound at high concentrations to prosthetic grafts have been proposed as adjunctive prophylaxis (6,9,15,19,20,22,24,26).…”

mentioning

confidence: 99%

Polycationic Peptides as Prophylactic Agents against Methicillin-Susceptible or Methicillin-Resistant Staphylococcus epidermidis Vascular Graft Infection

Giacometti

Cirioni

Ghiselli

et al. 2000

Antimicrob Agents Chemother

View full text Add to dashboard Cite

Several polycationic peptides isolated from animals, plants, and bacterial species possess a broad spectrum of antimicrobial activity. A rat model was used to investigate the efficacies of two peptides, ranalexin and buforin II, in the prevention of vascular prosthetic graft infections. The effect of peptide-soaked collagen-sealed Dacron was compared to that of rifampin-soaked collagen-sealed Dacron in the rat model of graft infection caused by methicillin-susceptible rifampin-susceptible Staphylococcus epidermidis and methicillin-resistant rifampin-susceptible S. epidermidis. Graft infections were established in the back subcutaneous tissue of 240 adult male Wistar rats by implantation of 1-cm 2 Dacron prostheses, followed by topical inoculation with 2 ؋ 10 7 CFU of S. epidermidis. The study included a control group (no graft contamination), two contaminated groups that did not receive any antibiotic prophylaxis, two contaminated groups to which perioperative intraperitoneal cefazolin prophylaxis (30 mg/kg of body weight) was administered, six contaminated groups that received a peptide-or rifampin-soaked graft, and six contaminated groups that received a peptide-or rifampin-soaked graft and perioperative intraperitoneal cefazolin prophylaxis (30 mg/kg). The grafts were sterilely removed 7 days after implantation, and the infection was evaluated by using sonication and quantitative agar culture. Overall, the efficacies of the polycationic peptides against the methicillin-susceptible and methicillin-resistant strains were not significantly different from that of rifampin. Nevertheless, the combinations of ranalexin-and buforin II-coated grafts with cefazolin treatment demonstrated efficacies significantly higher than that of the combination of rifampin-coated grafts and cefazolin treatment against the methicillin-resistant strain.

show abstract

Prevention of Vascular Graft Infection by Rifampin Bonding to a Gelatin-Sealed Dacron Graft

Cited by 87 publications

References 23 publications

Efficacy of Quinupristin-Dalfopristin in Preventing Vascular Graft Infection Due to Staphylococcus epidermidis with Intermediate Resistance to Glycopeptides

Efficacy of Quinupristin-Dalfopristin in Preventing Vascular Graft Infection Due to Staphylococcus epidermidis with Intermediate Resistance to Glycopeptides

A Case of In-Situ Reconstruction with a Rifampicin-Bonded Gelatin-Sealed Woven Dacron Graft for Prosthetic Graft Infection with Pseudoaneurysms after Ascending Aortic Replacement for Type A Dissection

Polycationic Peptides as Prophylactic Agents against Methicillin-Susceptible or Methicillin-Resistant Staphylococcus epidermidis Vascular Graft Infection

Contact Info

Product

Resources

About