Efficacy of Quinupristin-Dalfopristin in Preventing Vascular Graft Infection Due to Staphylococcus epidermidis with Intermediate Resistance to Glycopeptides

Profilaxia antimicrobiana em cirurgia vascular periférica: cefalosporina ainda é o padrão-ouro?

“…65 More recently, studies involving use of streptogramins (quinupristin/dalfopristin) have been conducted in animal models, with the aim of assessing its ability to prevent infections by methicillin-resistant Staphylococcus epidermidis and with intermediate resistance to glycopeptides. In the study by Giacometti et al, 68 there was a significant reduction in bacterial growth in grafts impregnated with the new drug, in vitro.…”

Pre-clinical in vivo Models of Vascular Graft Coating in the Prevention of Vascular Graft Infection: A Systematic Review

“…93 In six studies (6/35, 17.1%), graft and tissue healing was considered as safety monitoring. 61e63, 73,78,89 Finally, the ToxRTool graded five aspects of the outcome group (Supplementary Table S2: II.12, IV.17, IV.18, IV.19, V.21). The quantitative study results were considered reliable in 85.1% of the cases (n ¼ 80), the frequency and duration of exposure as well as observation time points was explained in all cases.…”

Antimicrobial Activity of Cefazolin‐impregnated Mesh Grafts

“…Despite using the aseptic surgical technique, the most important pathogen that causes foreign body infections is CNS 1 . The source of infection is colonization of the polymer surface by the patient’s own flora 5 . Methicillin‐resistant staphylococcus was preferred in this study because of the clinical frequency and the increasing resistance levels of this bacterium 16 .…”

“…Actually the foreign materials reduce the number of organisms required to establish infection (10 2 Staphylococcus aureus ) in comparison with normal skin (10 6 S. aureus ) 4 . The members of the normal mucocutaneous microflora, including coagulase‐negative staphylococci, S. aureus , Corynebacterium species and candida are among the most frequent microorganisms that can cause biomaterial‐associated infections 5,6 . The meshes as biomaterials may cause difficulty in the treatment of infections and most cases can be treated by the removal of meshes and/or antibiotic therapy 5,7 .…”

“…The members of the normal mucocutaneous microflora, including coagulase‐negative staphylococci, S. aureus , Corynebacterium species and candida are among the most frequent microorganisms that can cause biomaterial‐associated infections 5,6 . The meshes as biomaterials may cause difficulty in the treatment of infections and most cases can be treated by the removal of meshes and/or antibiotic therapy 5,7 . However, these infections may result in organ failure, amputation, metastatic infection and even death.…”