1999
DOI: 10.1590/s0074-02761999000700010
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Prevention of transfusional Trypanosoma cruzi infection in Latin America

Abstract: Trypanosoma cruzi is a protozoan infection widely spread in Latin America, from Mexico in the north to Argentina and Chile in the south. The second most important way of acquiring the infection is by blood transfusion. Even if most countries of Latin America have law/decree/norms, that make mandatory the screening of blood donors for infectious diseases, including T. cruzi (El Salvador and Nicaragua do not have laws on the subject), there is usually no enforcement or it is very lax. Analysis of published serol… Show more

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Cited by 92 publications
(76 citation statements)
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“…Because of difficulties associated with therapeutic treatment, and the elusive development of an effective vaccine, control of the transmission of Chagas disease remains based on vector control by insecticides (Silveira & Vinhaes 1999) and on blood bank screening (Schmuñis 1999). Vector control programs in South America have focused on the interruption of natural transmission by attacking domiciliated vector populations using pyrethroide insecticides (Silveira & Vinhaes 1999), and they have been enormously successful.…”
mentioning
confidence: 99%
“…Because of difficulties associated with therapeutic treatment, and the elusive development of an effective vaccine, control of the transmission of Chagas disease remains based on vector control by insecticides (Silveira & Vinhaes 1999) and on blood bank screening (Schmuñis 1999). Vector control programs in South America have focused on the interruption of natural transmission by attacking domiciliated vector populations using pyrethroide insecticides (Silveira & Vinhaes 1999), and they have been enormously successful.…”
mentioning
confidence: 99%
“…Furthermore, the MINSAL data did not include specific demographic data whose analysis, coupled with knowledge regarding T. cruzi infection through transfusion, could have provided more sensitive results. Nevertheless, we believe that these data were useful, as previous studies of Latin American countries using similar data [2,36,37] suggested that the prevalence of T. cruzi antibodies in blood donors is a good predictor of prevalence on a national scale, and that the findings provide important insights into the current epidemiology of Chagas disease in El Salvador.…”
Section: Discussionmentioning
confidence: 72%
“…Excepto los liofilizados de plasma y los hemoderivados, todos los componentes de la sangre son infectantes (5)(6)(7). Se estima que el riesgo de adquirir la enfermedad de Chagas al recibir una unidad infectada oscila entre 20% y 40%, cifras que pueden incrementarse, entre otras causas, por la elevada prevalencia en la población, por el largo tiempo de latencia de la infección, que para el caso de Chagas puede ser de varios años, la elevada prevalencia en donantes de sangre, la baja cobertura del tamizaje de las unidades de sangre donadas, el número de unidades de sangre transfundidas, la larga supervivencia del parásito en las unidades de sangre almacenadas en refrigeración, la falta de canalización y confirmación de donantes reactivos sospechosos de estar infectados, y la deficiencia en los controles de calidad durante el procesamiento de la sangre y sus componentes (8,9).…”
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