Prevention of Retrosternal Adhesion Formation in a Rabbit Model Using Bioresorbable Films of Polyethylene Glycol and Polylactic Acid

Okuyama, Naoki; Rodgers, Kathleen E.; Wang, Catherine Y.; Girgis, Wefki; Öz, Mehmet C.; Amand, Karen St.; Pines, Eli; DeCherney, Alexander H.; Rose, Eric A.; Cohn, Daniel; diZerega, Gere S.

doi:10.1006/jsre.1998.5317

Cited by 50 publications

(36 citation statements)

References 34 publications

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“…Many polymers such as polylactide acid (PLA), PVA, and polyethylene glycol have been used as barriers to prevent adhesion [22][23][24]. As a water-insoluble polymer, PLA does not swell in water [22] and has been clinically applied during surgery as degradable sutures [6].…”

Section: Discussionmentioning

confidence: 99%

Novel technique of overlaying a poly-l-lactic acid nanosheet for adhesion prophylaxis and fixation of intraperitoneal onlay polypropylene mesh in a rabbit model

et al. 2011

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Section: Discussionmentioning

confidence: 99%

Novel technique of overlaying a poly-l-lactic acid nanosheet for adhesion prophylaxis and fixation of intraperitoneal onlay polypropylene mesh in a rabbit model

et al. 2011

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“…[75] Additional investigations of the obtained polymer films using cells revealed the suppression effect of the hydrophilic polymers on the adhesion and consequent proliferation of cells, which can also be used for the prevention of adhesion after surgical procedures. [76,77] It could be demonstrated that, depending on the PEG content, cell adhesion could be varied from the formation of small cell aggregates or no cells to cell spreading comparable with the standard cell culture polymers, poly(lactic acid) or tissue culture polystyrene ( Figure 13). Moreover, it was shown that upon irradiation with UV light, the adhesion-suppressing properties are lost and complete removal of the PEG chains on the surface could be achieved due to cleavage of the bonds exposed to UV light on the surface of the films.…”

Section: Pla Surface Modification With Pegmentioning

confidence: 99%

Customized PEG‐Derived Copolymers for Tissue‐Engineering Applications

Teßmar

Göpferich

2007

Macromolecular Bioscience

190

132

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PEG-containing copolymers play a prominent role as biomaterials for different applications ranging from drug delivery to tissue engineering. These custom-designed materials offer enormous possibilities to change the overall characteristics of biomaterials by improving their biocompatibility and solubility, as well as their ability to crystallize in polymer blends and to resist protein adsorption. This article demonstrates various principles of PEG-based material design that are applied to fine tune the properties of biomaterials for different tissue engineering applications. More specifically, strategies are described to develop PEG copolymers with various block compositions and specific bulk properties, including low melting points and improved surface hydrophilicity. Highly hydrated polymer gel networks for promoting cellular growth or suppressing protein adsorption and cell adhesion are introduced. By incorporating selectively cleavable cross-links, these hydrophilic polymers can also serve as smart hydrogel scaffolds, mimicking the natural extracellular matrix for cell cultivation and tissue growth. Ultimately, these developments lead to the creation of biomimetic materials to immobilize bioactive compounds, allowing precise control of cellular adhesion and tissue growth. [image: see text]

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“…In addition to their use in classic applications, such as bioabsorbable sutures 1,2 and drug delivery systems, 3,4 their applicability recently expanded into new areas, such as selectively biodegradable vascular grafts, [5][6][7] noninvasive surgical procedures, 8,9 the prevention of postsurgical adhesions, [10][11][12] and tissue engineering. [13][14][15] Poly(-caprolactone) (PCL) is being used in clinics as a surgical material, and some of the most commonly reported PCL biomedical applications are controlled drug delivery systems 16 and implants for orthopedic surgery.…”

Section: Introductionmentioning

confidence: 99%

Biodegradable poly(ethylene oxide)/poly(ϵ‐caprolactone) multiblock copolymers

Cohn

Stern

González

et al. 2001

J. Biomed. Mater. Res.

Self Cite

108

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A series of poly(ethylene oxide) (PEO)/poly(epsilon-caprolactone) (PCL) containing biodegradable poly(ether ester urethane)s, covering a wide range of compositions, were synthesized and characterized. The synthesis consisted of a two-step process. During the first step, the ring-opening reaction of epsilon-caprolactone was carried out, initiated by the hydroxyl terminal groups of the PEO chain. The second step involved the chain extension of these PCL-PEO-PCL trimers with hexamethylene diisocyanate. By varying either the ethylene oxide/epsilon-caprolactone ratio or the length of both segments, we obtained a series of polymers having different morphologies and displaying a broad range of properties.

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Prevention of Retrosternal Adhesion Formation in a Rabbit Model Using Bioresorbable Films of Polyethylene Glycol and Polylactic Acid

Cited by 50 publications

References 34 publications

Novel technique of overlaying a poly-l-lactic acid nanosheet for adhesion prophylaxis and fixation of intraperitoneal onlay polypropylene mesh in a rabbit model

Novel technique of overlaying a poly-l-lactic acid nanosheet for adhesion prophylaxis and fixation of intraperitoneal onlay polypropylene mesh in a rabbit model

Customized PEG‐Derived Copolymers for Tissue‐Engineering Applications

Biodegradable poly(ethylene oxide)/poly(ϵ‐caprolactone) multiblock copolymers

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