Prevention of retrolental fibroplasia in very low birth weight infants by D-penicillamine

Lakatos, L; Hatvani, I; Oroszlán, G; Karmazsin, L

doi:10.1007/bf00441157

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Additional References Aiello 19961

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1982

2013

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Cited by 12 publications

(2 citation statements)

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“…A single-centre, randomised, prospective controlled trial 1974to 1978, 1979, 1981to 1982. Lakatos 1988 Correspondence to editor referring to the included trials No new trials were located in the search done in April 2002, and as a result, no substantive changes were made in the review.…”

Section: Additional References Aiello 1996mentioning

confidence: 99%

D-Penicillamine for preventing retinopathy of prematurity in preterm infants

Qureshi

Kumar

2013

Cochrane Database of Systematic Reviews

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Section: Additional References Aiello 1996mentioning

confidence: 99%

D-Penicillamine for preventing retinopathy of prematurity in preterm infants

Qureshi

Kumar

2013

Cochrane Database of Systematic Reviews

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“…Currently, the popular theory on the chem ical mechanism of oxygen toxicity is that specific cell damage is caused primarily by the production of oxygen radicals or other chemically active Recently we have reported that DPA treatment in the neonatal period of life is associated with a marked decrease in the incidence of severe RLF among very low birth weight infants [12,13]. In the present study, we sought to determine the extent to which DPA modifies acute radiosensitivity on 3-to 4-day-old mice in comparison with adult animals.…”

Section: Introductionmentioning

confidence: 99%

Age-Related Difference in Radioprotective Effect of D-Penicillamine

Lakatos¹,

Oroszlán²,

Dezsi³

et al. 1982

Dev Pharmacol Ther

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D-Penicillamine, previously suspected to have a beneficial effect on the occurrence of severe retrolental fibroplasia among very low birth weight infants, was tested to determine the extent to which this drug modifies acute radiosensitivity on 3- to 4- day-old mice in comparison with adult animals. It was found that the radioprotective effect of penicillamine, given in doses of 3,000 mg/kg i.p. 60 min before whole-body exposure to 6-10 Gy of 60Co gamma rays, was greater in 3- to 4-day-old mice than in adult animals. These data seem to be compatible with the view that D-penicillamine, by virtue of its antioxidant action, may reduce the toxic effects associated with exposure of the newborn infant to hyperoxia, specifically retrolental fibroplasia and bronchopulmonary dysplasia.

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