Prevention of restrictive adhesions in primary tendon repair by HA-membrane: experimental research in chickens

The prevention of peritendinous adhesions by a phospholipid polymer hydrogel formed in situ by spontaneous intermolecular interactions

“…These materials, however, failed because they prevented nutrient diffusion to the healing tendon leading to tendon necrosis [12,14,15]. Although the focus has recently turned to diffusible membranes of polytetrafluoroethylene [16], hyaluronic acid membrane [17], poly(vinyl alcohol) hydrogel (PVA-H) [15], and hydrogel sealant (FocalSeal-L) [18], most of them are cumbersome to use and difficult to prepare.…”

“…Despite advances in surgical techniques and rehabilitation programs [7,8], the results of tendon repair within the sheath remain largely unpredictable [1,2]. Hence, many modalities have been investigated to prevent adhesion formation such as the use of pharmacologic modulators or mechanical barriers between the tendon and surrounding tissues [9][10][11][12][13][14][15][16][17][18].…”

Hyaluronic acid diminishes the resistance to excursion after flexor tendon repair: An in vitro biomechanical study

“…Several experimental reports have claimed that exogenously administered sodium hyaluronate helps to prevent the formation of adhesions (Amiel et al, 1989;Gaughan et al, 1991;Hagberg, 1992;Isik et al, 1999;Wiig et al, 1997). While these articles have studied the effect of administration of HA, evaluation was limited to gross inspection, histological examination or final range of motion (Isik et al, 1999).…”

Preparation and characterization of antiadhesion barrier film from hyaluronic acid-grafted electrospun poly(caprolactone) nanofibrous membranes for prevention of flexor tendon postoperative peritendinous adhesion

“…Indeed, previous reports have indicated that membranes made from HA can prevent peritendinous adhesions when used as physical barriers. 13 Electrospinning (ES) is a versatile method for the preparation of fibers from natural and synthetic polymers with dimensions ranging from a few nanometers to several micrometers. During the ES process, random nanofibers form on a grounded collector when a polymer solution is pushed out from a needle at a constant rate under a high applied voltage.…”