The prevention of peritendinous adhesions by a phospholipid polymer hydrogel formed in situ by spontaneous intermolecular interactions

Ishiyama, Noriyuki; Moro, Toru; Ishihara, Kazuhíko; Ohe, Takashi; Miura, Toshiki; Konno, Tomohiro; Ohyama, Tadashi; Kimura, Masanari; Kyomoto, Masayuki; Nakamura, Kozo; Kawaguchi, Hiroshi

doi:10.1016/j.biomaterials.2010.01.100

Cited by 77 publications

(57 citation statements)

References 41 publications

(68 reference statements)

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“…A macroscopic adhesion grading system was implemented to estimate the severity of adhesion around the repaired tendon by two surgeons who were blinded to the groups. The grading system includes: grade 1, no marked adhesion; grade 2, filmy adhesion that could be readily separated using blunt dissection; grade 3, mild adhesion (>97.5% of the adhesion area could be separated using sharp dissection); grade 4, moderate adhesion (51%-97.5% of the adhesion area could be separated using sharp dissection); grade 5, severe adhesion (≤50% of the adhesion area could be separated using sharp dissection) [25,26].…”

Section: Gross Evaluationmentioning

confidence: 99%

Prevention of peritendinous adhesions with electrospun polyethylene glycol/polycaprolactone nanofibrous membranes

Chen

Shalumon

et al. 2015

Colloids and Surfaces B: Biointerfaces

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Section: Gross Evaluationmentioning

confidence: 99%

Prevention of peritendinous adhesions with electrospun polyethylene glycol/polycaprolactone nanofibrous membranes

Chen

Shalumon

et al. 2015

Colloids and Surfaces B: Biointerfaces

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“…The severity of peritendinous adhesion was evaluated by an adhesion scoring system 19 that was used to grade a particular area based on the surgical findings: grade 1, no adhesion; grade 2, adhesion area can be separated by blunt dissection alone; grade 3, adhesion area #50% which requires sharp dissection for separation; grade 4, adhesion area of 51%-97.5% which requires sharp dissection for separation; and grade 5, adhesion area of .97.5% requiring sharp dissection for separation. This was performed subjectively by an investigator skilled in performing surgery but blinded to the treatment groups to eliminate any bias.…”

Section: Macroscopic Evaluation and Peritendinous Adhesion Scoringmentioning

confidence: 99%

Controlled release of curcumin from curcumin-loaded nanomicelles to prevent peritendinous adhesion during Achilles tendon healing in rats

Zhang¹,

Li²,

Franchini³

et al. 2016

IJN

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We introduced curcumin-loaded nanomicelles into a tendon-healing model to evaluate their effects on tendon healing and adhesion. Three groups consisting of 36 rats underwent rupture and repair of the Achilles tendon. The treatment group received an injection of curcumin-loaded nanomicelles (gold nanorods [GNRs]-1/curcumin in polymeric nanomicelles [curc@PMs] at a dosage of 0.44 mg curcumin/kg in 0.1 mL saline) into the surgical site and exposed to laser postoperatively at weeks 1, 2, and 3, for three times 10 seconds each, on the surgical site in the rats that underwent tendon rupture and repair, while the other two groups received 0.44 mg curcumin/kg in 0.1 mL saline and 0.1 mL of saline, respectively. The specimens were harvested at 4 weeks and subjected to biomechanical and histological evaluation. The scoring results of tendon adhesion indicated that GNRs-1/curc@PMs group was in the lowest grade of peritendinous adhesions compared to the other groups. Histological assessment further confirmed the preventive effect of GNRs-1/curc@PMs on tendon adhesion. These findings indicated greater tendon strength with less adhesion in the group treated with GNRs-1/curc@PMs combined with laser exposure, and that nanoparticle-based therapy may be applied to prevent adhesion in clinical patients.

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“…An adhesion scoring system according to previous studies 8,25 was used based on the surgical findings as follows: grade 1, no adhesion; grade 2, adhesion area can be separated by blunt dissection alone; grade 3, adhesion area less than or equal to 50% and required sharp dissection for separation; grade 4, 51-97.5% adhesion area that required sharp dissection for separation; and grade 5, more than 97.5% of the adhesion area that required sharp dissection for separation. The measurements were carried out by two investigators who were blinded to the experimental grouping.…”

Section: Adhesion Scoresmentioning

confidence: 99%

“…UTMD-mediated gene delivery has the advantages of high transfection efficiency, low immunogenicity and toxicity, repeatability and spatial target specificity. 3,8 In term of studies of UTMD involved with the tendon, Qiu et al 3 reported that the most favourable ultrasound conditions for the tendon consisted of an ultrasound pulse with 2 W cm −2 of output intensity and a 20% duty cycle for 10 min with local injection of microbubbles agent. The purpose of this study was to determine whether using UTMD to transfect wounded Achilles tendon with IGF-1 cDNA in rats would enhance regeneration of the tendon.…”

Section: Introductionmentioning

confidence: 99%

Use of ultrasound-targeted microbubble destruction to transfect IGF-1 cDNA to enhance the regeneration of rat wounded Achilles tendon in vivo

et al. 2015

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The purpose of this study was to determine whether using ultrasound-targeted microbubble destruction (UTMD) to transfect rat wounded Achilles tendon with insulin-like growth factor-1 (IGF-1) cDNA would enhance tissue regeneration. Forty rats with injured Achilles tendons were transfected with IGF-1 cDNA and divided into: (1) control group, (2) plasmid-only group, (3) plasmid+ultrasound group and (4) plasmid+microbubbles+ultrasound group. The IGF-1 cDNA expression of the Achilles tendons was evaluated by histological adhesion finding, quantitative real-time reverse transcription PCR examination and biomechanical test. The adhesion scores in group 4 were lowest at weeks 2 and 8 (P<0.05). The IGF-1 expression in the Achilles tendons was highest in group 4 at weeks 2 and 8 (P<0.05). Compared with those of other three groups, the granulation tissues and inflammatory-cell infiltration were lighter in group 4 at week 2, and the scars on the tendons in group 4 were less evident at week 8. The messenger RNA (mRNA) of IGF-1 of group 4 was upregulated at weeks 2 and 8 (P<0.01). Groups 4 and 3 showed a greater maximum load, stiffness and ultimate stress (P<0.05). Maximum load, stiffness and ultimate stress of healing Achilles tendons in group 4 were highest at weeks 2 and 8 (P<0.05).

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The prevention of peritendinous adhesions by a phospholipid polymer hydrogel formed in situ by spontaneous intermolecular interactions

Cited by 77 publications

References 41 publications

Prevention of peritendinous adhesions with electrospun polyethylene glycol/polycaprolactone nanofibrous membranes

Prevention of peritendinous adhesions with electrospun polyethylene glycol/polycaprolactone nanofibrous membranes

Controlled release of curcumin from curcumin-loaded nanomicelles to prevent peritendinous adhesion during Achilles tendon healing in rats

Use of ultrasound-targeted microbubble destruction to transfect IGF-1 cDNA to enhance the regeneration of rat wounded Achilles tendon in vivo

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