Prevention of radiation-induced mucositis

Abstract

Radiation-induced mucositis is an important dose-limiting acute side effect associated with the treatment of tumors of the upper aerodigestive tract. The toxicity of radiation therapy increases with prior or concurrent administration of some chemotherapeutic agents. Pretreatment eradication of infection, maintenance of oral hygiene, and treatment breaks, as necessary, have been the mainstay of the therapeutic options for patients with radiation-induced mucositis. Recent research has begun to clarify the pathophysiology of radiation-induced mucositis. This suggests that new, more effective agents for both prevention and treatment may be forthcoming in the near future. Currently, no highly effective and widely accepted prevention or treatment exists.

Zur Prophylaxe und Therapie der Radiodermatitis und Radiomucositis

“…Als Risikofaktoren der Strahlentherapie‐assoziierten Mucositis gelten schlechte Mundhygiene, Rauchen und bakterielle Besiedlung (47, 31). Die Radiomucositis stellt eine immunologische und zytokin‐vermittelte Entzündungsreaktion dar (26).…”

Tratamento da mucosite oral radio e quimioinduzida: comparação entre protocolo medicamentoso convencional e tratamentos com lasers em baixa intensidade

“…Não existe intervenção farmacológica largamente reconhecida como efetiva na prevenção e tratamento da MO radioinduzida (JOHNSON, 2001;MCGUIRE et al, 2006). Sendo o manejo da mesma em pacientes com câncer essencialmente paliativo (BENSADOUN et al, 1999;SCULLY et al, 2004;BONAN et al, 2005) apresentando como objetivos principais o alívio dos sintomas e a prevenção de complicações secundárias como a desidratação, caquexia e infecções, permitindo uma melhor qualidade de vida (KOSTLER et al, 2001).…”