Intraoral melanoma: long-term follow-up and implication for dental clinicians. a case report and literature review

Gu, Gao Man; Epstein, Joel B.; Morton, Thomas Hellman

doi:10.1016/s1079-2104(03)00320-2

“…Recurrence may occur 10 to 15 years after treatment of the primary tumor. Distant metastasis to the lungs, brain, liver and bone may occur in advanced stages of the disease (6).…”

Section: Discussionmentioning

confidence: 99%

Structure-Based Virtual Screening: Identification of Novel Quorum-Sensing Inhibitors to Interfere with the Formation of Pseudomonas aeruginosa Biofilm

Jafari‐Sabet

¹

,

Baratian

²

2017

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Introduction: Primary malignant melanoma of the oral cavity is a rare occurrence. This tumor, compared to other malignant tumors of the oral cavity, has higher tendency to metastasize or locally invade the adjacent structures. Its most common site of occurrence in the oral cavity is the palate followed by the maxillary gingiva. Oral melanoma does not have a pathognomonic clinical manifestation and in rare cases, it may not even cause clinical discoloration of the mucosa either; in this case, it is referred to as amelanotic melanoma. Most cases of amelanotic melanomas are metastatic rather than primary tumors. The Survival rate of patients with mucosal melanoma is lower than that of patients with cutaneous melanoma. Prognosis is much poorer for amelanotic melanoma due to difficult and delayed diagnosis compared to cutaneous melanoma. Case Presentation: In this study, a 33-year-old white male presented to the oral medicine department of Shahed University, school of dentistry, complaining of an extensive pink-redexophytic mass on the attached gingiva of the maxillary right central incisor extending posteriorly to the maxillary right first molar. He had it for the past five months. The patient had no systemic disease and the panoramic radiograph of the patient showed no pathological lesion.

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“…Treatment of malignant melanoma depends on the extension of lesion and may include surgery, radiotherapy, chemotherapy and immunotherapy (6). In some cases with primary small lesions, surgical removal of the mass along with a minimum of 1.5 cm of healthy margin may suffice (16).…”

Section: Discussionmentioning

confidence: 99%

“…Palate followed by maxillary gingiva is the most common site of occurrence of oral melanoma (4). The prevalence of oral melanoma is higher among black people and Japanese compared to other populations (5,6). Also, oral melanoma is more commonly seen in males compared to females and in patients over 50 years (2,6).…”

Section: Introductionmentioning

confidence: 99%

Amelanotic Primary Malignant Melanoma of the Maxilla: A Case Report

Esmaeili

¹

,

Hosseini

²

2017

J Arch Mil Med

0

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Introduction: Primary malignant melanoma of the oral cavity is a rare occurrence. This tumor, compared to other malignant tumors of the oral cavity, has higher tendency to metastasize or locally invade the adjacent structures. Its most common site of occurrence in the oral cavity is the palate followed by the maxillary gingiva. Oral melanoma does not have a pathognomonic clinical manifestation and in rare cases, it may not even cause clinical discoloration of the mucosa either; in this case, it is referred to as amelanotic melanoma. Most cases of amelanotic melanomas are metastatic rather than primary tumors. The Survival rate of patients with mucosal melanoma is lower than that of patients with cutaneous melanoma. Prognosis is much poorer for amelanotic melanoma due to difficult and delayed diagnosis compared to cutaneous melanoma. Case Presentation: In this study, a 33-year-old white male presented to the oral medicine department of Shahed University, school of dentistry, complaining of an extensive pink-redexophytic mass on the attached gingiva of the maxillary right central incisor extending posteriorly to the maxillary right first molar. He had it for the past five months. The patient had no systemic disease and the panoramic radiograph of the patient showed no pathological lesion.

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“…Il joue un rôle non seulement dans le dépistage précoce des lésions pigmentées de la muqueuse buccale, mais aussi dans la prise en charge du patient au sein de l'équipe pluri-disciplinaire. Il intervient éga-lement dans la surveillance post-opératoire qui est primordiale et qui permet de diagnostiquer précocément l'apparition d'un deuxième mélanome, d'une récidive ou d'une métastase [23].…”

Section: Discussionunclassified

Mélanomes de la cavité buccale : présentation de 3 cas

Haïtami¹,

Yahya²,

Kinani³

et al. 2011

Med Buccale Chir Buccale

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Résumé -Le mélanome est une tumeur qui se développe à partir des cellules pigmentaires dérivant des crêtes neurales. Les mélanomes buccaux constituent 0,4 à 8 % de l'ensemble des tumeurs mélaniques. Ils atteignent plus l'homme entre 50 et 60 ans, et se développent essentiellement sur la muqueuse palatine, la gencive, les lèvres. L'étiopathogénie demeure inconnue; il existerait cependant une prédisposition génétique mais aucun précurseur bien défini n'a été isolé. Les microtraumatismes répétés sur un naevus bénin pré-existant ont également été incriminés. L'évolution du mélanome se fait en 2 phases : d'abord horizontalement, puis verticalement. La très haute malignité, l'agressivité et le sombre pronostic de cette tumeur en font une entité dont le diagnostic précoce permet d'améliorer de façon importante le taux de survie des patients. Nous présentons 3 cas de mélanomes dont le diagnostic tardif a rendu la prise en charge difficile et le pronostic sombre.Abstract -Oral melanoma: 3 cases report. The melanoma is a tumor which develops from the pigmentary cells diverting neural crests. The oral melanomas constitute 0.4 to 8% of all the melanic tumors. They affect more the men between 50 and 60 years, essentially at the palatine mucous membrane, the gum, the lips. The etiopathogeny is unknown; there would be however a genetic predisposition but no well defined precursor was isolated. The repeated microtraumas on a pre-existing mild naevus were also incriminated. The evolution is made in 2 phases: at first horizontally then vertically. The very high wickedness, the aggressiveness and the somber forecast of these tumors make it entities in which the early diagnosis allows to improve the rate of survival of the patients. We present through this work 3 cases of oral melanomas; the late diagnosis maked the care difficult and the prognosis dark.

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Intraoral melanoma: long-term follow-up and implication for dental clinicians. a case report and literature review

Cited by 56 publications

References 35 publications

Structure-Based Virtual Screening: Identification of Novel Quorum-Sensing Inhibitors to Interfere with the Formation of Pseudomonas aeruginosa Biofilm

Structure-Based Virtual Screening: Identification of Novel Quorum-Sensing Inhibitors to Interfere with the Formation of Pseudomonas aeruginosa Biofilm

Amelanotic Primary Malignant Melanoma of the Maxilla: A Case Report

Mélanomes de la cavité buccale : présentation de 3 cas

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