Prevention of radiation-induced hepatic damage in Swiss albino mice by Aloe Vera leaf extract

Abstract

The radioprotective effect of the Aloe vera leaf extract was studied in Swiss albino mice against radiation-induced changes in the liver. The mice were treated with 1000 mg/kg of body weight orally, once a day for 15 consecutive days, before exposure to a single dose of gamma radiation (6 Gy), half an hour after the last administration. The irradiation of mice caused a significant elevation in lipid peroxidation followed by a decrease in glutathione, acid phosphatase and alkaline phosphatase. The treatment of mice before irradiation elevated the glutathione, acid phosphatase and alkaline phosphatase, and was accompanied by a decline in lipid peroxidation. Recovery and regeneration from radiation damage were faster in pretreated animals than the animals in the irradiation-only group. The data clearly indicate that the Aloe vera leaf extract significantly reduced the deleterious effects of radiation on the liver and it could be a useful agent in reducing the side effects of therapeutic radiation

Radiation‐Induced Testicular Injury and Its Amelioration by Tinospora cordifolia (An Indian Medicinal Plant) Extract

“…Afterwards, it tended to be utilized less due to the declining impact of radiation and endogenous reparative homeostatic activity. Previous findings from our laboratory [ 50 , 51 ] strongly suggest that radiation-induced depletion of glutathione resulted in an enhanced LPO as also observed in testicular tissue by Faidan et al [ 52 ]. Since biomembranes of testicular tissues are rich in polyunsaturated fatty acid content and radiation-induced damage is mediated by peroxidation of membrane lipids, therefore, the estimation of LPO is important to monitor oxidative damage to cellular membranes [ 53 ].…”

Aloe vera modulates X-ray induced hematological and splenic tissue damage in mice

“…Previously documented studies also exhibited enhanced LPO levels in hepatic and testicular tissues of animals upon gamma-ray exposure, which was improved by the administration of A. vera. 11,82,83 The amount of LDH enzyme in the serum reflects alterations in the plasma membrane integrity and/or permeability. 84 It has been reported by various authors that elevated activity of LDH was observed after irradiation of serum, thymus, liver, spleen, kidney, and testis of mice.…”

D-Riboce-L-Cystein Maintained Testicular Integrity in Rats Model (<i>Rattus Novergicus</i>) Exposed to X-Ray

“…It also promotes the production of inflammatory cytokines [13]. Riboceine is a unique molecule that combines ribose and cysteine, nutrients that occur naturally in the body [14]. Riboceine once ingested will be absorbed, enters the bloodstream and delivers cysteine and ribose to the cells, supporting glutathione production as well as providing ribose, an integral part of ATP, cells natural fuel and source of energy.…”

“…Riboceine once ingested will be absorbed, enters the bloodstream and delivers cysteine and ribose to the cells, supporting glutathione production as well as providing ribose, an integral part of ATP, cells natural fuel and source of energy. Riboceine significantly out formed other means of glutathione enhancement [14]. This research project is aimed to study the effect of D-Riboce-L-cysteine on radiation (X-ray)-induced oxidative stress in rat testes.…”