Prevention of Preterm Labour: 2011 Update on Tocolysis

Hubinont, Corinne; Debiève, Frédéric

doi:10.1155/2011/941057

Cited by 50 publications

(37 citation statements)

References 37 publications

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“…Additionally, molecular mechanisms regulating parturition and onset of labor in women are still being defined. Greater understanding of OXTR signaling in the primate uterus might help reduce complications from onset of preterm labor (Hubinont and Debieve, 2011). …”

Section: Discussionmentioning

confidence: 99%

Progesterone inhibition of oxytocin signaling in endometrium

Bishop¹

2013

Front. Neurosci.

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Expression of the oxytocin receptor (OXTR) in the endometrium of ruminant species is regulated by the ovarian steroids progesterone (P) and estradiol (E). Near the end of the estrous cycle, long-term exposure of endometrial epithelial cells to P results in loss of genomic P receptors (PGRs), leading to an increase in E receptors (ERs). Genomic regulation of the OXTR is mediated via suppression of ER signaling by P. Upon OT binding at the plasma membrane of endometrial cells, a signaling cascade is generated stimulating release of prostaglandin F2α (PGF2α). Transport of PGF2α to the ovary results in release of OT by luteal cells in a positive feedback loop leading to luteal regression. This signaling cascade can be rapidly blocked by exposing endometrial cells to physiologic levels of P. This mini review will focus on the mechanisms by which P may act to block OXTR signaling and the luteolytic cascade in the ruminant endometrium, with special focus on both non-genomic signaling pathways and non-receptor actions of P at the level of the plasma membrane. While this review focuses on ruminant species, non-classical blockage of OXTR signaling may be important for fertility in women.

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Section: Discussionmentioning

confidence: 99%

Progesterone inhibition of oxytocin signaling in endometrium

Bishop¹

2013

Front. Neurosci.

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“…Earlier research showed an increase in PTB associated with cerclage in twin pregnancies [35]. Antibiotics PPROM Prolongation of pregnancy, reduced neonatal morbidity [43,45] No trial compared vaginal progesterone and cerclage in PTB prevention. An indirect comparison [36] found no difference between either vaginal progesterone or cerclage in the prevention of PTB in women with a sonographic short cervix in the mid trimester, singleton gestation, and previous PTB.…”

Section: Secondary Preventionmentioning

confidence: 99%

Preterm Birth Prevention: How Well Are We Really Doing? A Review of the Latest Literature

Avraham

Azem

Seidman

2014

J Obstet Gynecol India

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“…Prostaglandin F 2α (PGF 2α ) is released from the uterus in large amounts during parturition, and this is commonly assumed to initiate labour contractions in pregnant cows 8 . PGs are well-known uterine contraction inducer by enhancing myometrial gap junction and increasing intracellular calcium concentration 9 . The increase in PG during labour causes increased uterine contractility and inhibitors of PG synthesis delay the onset of labour 10 .…”

Section: öZetmentioning

confidence: 99%

PCB-153 İle İnkübe Edilen Sığır Miyometriumu Üzerine Diklofenak Potasyum ve Diklofenak Sodyumun Tokolitik Etkisi

Daş¹,

Aksoy²,

Yavuz³

et al. 2013

Kafkas Univ Vet Fak Derg

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SummaryIn this study, the tocolytic effects of the potassium and sodium salts of diclofenac, a non-steroidal anti-inflammatory drug (NSAID), on cattle myometria were investigated in the presence of an estrogenic polychlorinated biphenyl congener 2,2 ' ,4,4' ,5,. The uterine samples were obtained from newly slaughtered, non-pregnant cattle more than two years old and in the anoestrus stage. Eight groups were constituted for testing (each group contained 8 strips from two animals, with 4 from each); there were four control groups (diclofenac potassium 24 h and 48 h; diclofenac sodium 24 h and 48 h) and four groups for PCB-153 (diclofenac potassium 24 h and 48 h; diclofenac sodium 24 h and 48 h). The control groups were incubated in physiological salt solution (PSS) for 24 or 48 hours and the PCB-153 groups were incubated in PSS which contained 100 ng/mL of PCB-153, for either 24 h or 48 h. After the incubation period, the strips were hung and incubated in the tissue bath system until spontaneous contractions occurred. Oxytocin (OT) was administered at 0.5 nM to the strips in all groups for the stimulation of spontaneous contractions. Diclofenac potassium and diclofenac sodium were then administered cumulatively in the range of 1x10 -7 to 7x10 -4 M to the strips of all groups to the maximum inhibitory effect was observed. After each application, isometric uterine contractions were recorded for 20 min. Mean peak amplitude (P MAX ), frequency (beats per minutes, BPM) and area under the curve (AUC) values of the myometrial contractions, which are criteria for determining drug effects, were calculated from the curve and evaluated statistically. The inhibitory concentration 50 (IC 50 ) values were calculated for the BPM, P MAX and AUC values of the myometrial contractions. Finally, the tocolytic effects of diclofenac potassium and diclofenac sodium on the contractions of cattle uterine strips pre-incubated with PCB-153, were determined. Keywords: Diclofenac potassium, Diclofenac sodium, PCB-153, Cattle, Tocolysis PCB-153 İle İnkübe Edilen Sığır Miyometriumu Üzerine Diklofenak Potasyum ve Diklofenak Sodyumun Tokolitik Etkisi ÖzetBu çalışmada, steroid yapıda olmayan ağrı kesici ve yangı giderici ilaçlardan (non steroidal anti-inflammatory drugs, NSAIDs) diklofenakın potasyum ve sodyum tuzlarının poliklorlu bifenil (PCB)'lerden östrojenik etkili 2,2' ,4,4' ,5,5'-hekzaklorobifenil (PCB-153) varlığında sığır uterus düz kaslarını gevşetici etkisi araştırılmıştır. Uterus örnekleri mezbahada iki yaşın üzerinde, yeni kesilen, anöstrüs evresinde, gebe olmayan ineklerden sağlanmıştır. İlaçların etkisini ortaya koymak için, dört kontrol (diklofenak potasyum 24 ve 48 saat, diklofenak sodyum 24 ve 48 saat) ve dört PCB-153 (diklofenak potasyum 24 ve 48 saat, diklofenak sodyum 24 ve 48 saat) olmak üzere sekiz ayrı grup oluşturulmuştur. Her bir grup iki farklı hayvandan dörder olmak üzere toplam sekiz miyometrium şeridi içermektedir. Kontrol grupları ayrı ayrı 24 ve 48 saat süre ile fizyolojik tuz solüsyonu (physiological salt saline, P...

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Prevention of Preterm Labour: 2011 Update on Tocolysis

Cited by 50 publications

References 37 publications

Progesterone inhibition of oxytocin signaling in endometrium

Progesterone inhibition of oxytocin signaling in endometrium

Preterm Birth Prevention: How Well Are We Really Doing? A Review of the Latest Literature

PCB-153 İle İnkübe Edilen Sığır Miyometriumu Üzerine Diklofenak Potasyum ve Diklofenak Sodyumun Tokolitik Etkisi

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