Prevention of Postoperative Adhesions by Single Intraperitoneal Medication

Treutner, K.‐H.; Bertram, P.; Lerch, Markus M.; Klimaszewski, M.; Petrovic-Källhom, Suzanna; Sobesky, Jan; Winkeltau, G.; Schumpelick, Volker

doi:10.1006/jsre.1995.1237

Cited by 56 publications

(64 citation statements)

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“…Taurolidine (TN), or bis(1,1-dioxoperhydro-1,2,4-thiodiazinyl-4)-methane, is an antibacterial drug originally synthesised in 1970 with activity against a broad spectrum of microorganisms and has been used as a safe lavage antibiotic to prevent bacterial infection in patients after abdominal surgery [6].…”

mentioning

confidence: 99%

Taurolidine and oxidative stress: a rationale for local treatment of mesothelioma

Aceto¹,

Bertino²,

Barbone³

et al. 2009

European Respiratory Journal

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Malignant mesothelioma is an asbestos-related, aggressive tumour, resistant to most anticancer therapies. Akt is a key mediator of mesothelioma cell survival and chemoresistance. This study aimed to clarify the mechanism by which taurolidine (TN), a known synthetic compound with antimicrobial and antineoplastic properties, leads to mesothelioma cell death.Apoptosis was studied by annexin V binding, cell cycle analysis, caspase-8 activation, poly(ADP-ribose) polymerase (PARP) cleavage and terminal deoxynucleotidyl transferasemediated deoxyuridine triphosphate nick-end labelling (TUNEL). Oxidative stress was measured by nitrite production and DNA oxidative damage. Protein expression and phosphorylation were evaluated by immunoprecipitation and immunoblotting.TN induces cell death of mesothelioma cells, but not of non-neoplastic human mesothelial cells. After TN treatment of mesothelioma cells, Akt but not extracellular signal-regulated kinase (Erk) 1/ 2 activity is inhibited a in time-and dose-dependent manner. Protein phosphatase (PP)1a and PP2A are activated several hours after drug addition. Apoptosis induced by TN is driven by oxidative stress and cell exposure to sulfydryl donors, such as glutathione monoethylester and L-N-acetylcysteine, significantly reduced pro-apoptotic effects and Akt inhibition. Conversely, expression of constitutively activated Akt did not affect cytoxicity elicited by TN, which retained its ability to inhibit the kinase.TN induces mesothelioma cell death via oxidative stress, accompanied by inhibition of Akt signalling. This provides a promising molecular rationale for TN as local treatment of malignant mesothelioma.

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confidence: 99%

Taurolidine and oxidative stress: a rationale for local treatment of mesothelioma

Aceto¹,

Bertino²,

Barbone³

et al. 2009

European Respiratory Journal

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“…On the other hand, saline is used generally as control in the peritoneal adhesion models of intraabdominal medication. When saline lavage or installation is included into the experimental groups, three different results are observed; beneficial, [10][11][12][13][14] ineffective, [9,[15][16][17][18] or even harmful. [19,20] Another challenge in peritoneal adhesion studies is the use of several different models.…”

Section: Discussionmentioning

confidence: 99%

Effects of saline lavage temperature on peritoneal fibrinolysis and adhesion formation

Koca

Tarhan

Kaya

et al. 2015

Ulus Travma Acil Cerrahi Derg

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“…Para esses escores, nossos resultados foram mais satisfatórios (75%). A ação dos corticóides se deve em parte a sua habilidade em reduzir a permeabilidade vascular, estabilizando os lisossomos e reduzindo os efeitos subseqüentes das histaminas, impedindo a proliferação, migração e organização dos fibroblastos 11,22 . No grupo GL-D70 observamos a ausência do escore 4+.…”

Section: Discussionunclassified

Prevenção de aderências pélvicas: estudo experimental em ratas com diferentes modalidades terapêuticas

Pacheco¹,

Dias²,

Silva³

et al. 2003

Rev. Bras. Ginecol. Obstet.

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Prevention of Postoperative Adhesions by Single Intraperitoneal Medication

Cited by 56 publications

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Taurolidine and oxidative stress: a rationale for local treatment of mesothelioma

Taurolidine and oxidative stress: a rationale for local treatment of mesothelioma

Effects of saline lavage temperature on peritoneal fibrinolysis and adhesion formation

Prevenção de aderências pélvicas: estudo experimental em ratas com diferentes modalidades terapêuticas

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