Prevention of post-traumatic osteoarthritis after intra-articular knee fractures using hyaluronic acid: a randomized prospective pilot study

Barakat, Ahmed Samir; Ibrahim, Nour; Elghobashy, Osama; Sultan, Ahmed Maher; Abdel-Kader, Khaled

doi:10.1007/s00264-019-04360-8

Cited by 8 publications

(9 citation statements)

References 28 publications

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“…However, recent research has shown that mild hyperthermia actually supports the differentiation of satellite cells and stem cells, a crucial step in the late proliferation and early remodeling phases of healing [42,43]. Although the optimal Hong Z et al 12 9 Llion et al 38 6 Barakat AS et al 15 5 Ellefsen et al 53 7 Aydogdu et al 31 6 Gilsanz et al 56 5 Anandkumare et al 32 9 Lohman et al 58 6 Mutlu et al 34 9 Simão et al 59 7 D'Souza et al 36 6 Wang et al 60 9 procedure (i.e., time, duration, temperature, and intervals) for controlled hyperthermia has not been confirmed, research by Guo et al demonstrated pilot results in which the observed moderate hyperthermia at the late inflammatory phase upregulated the production of myofibril proteins through the late stages of myogenesis. Additionally, the results showed an induced differentiation of myotubes over 72 hours compared to cells that were not exposed to mild hyperthermia [44].…”

Section: Moderate Hyperthermia Inductionmentioning

confidence: 99%

“…The extracellular matrix surrounding the mesenchymal tissue constrains the various proteins and connective fibers, including glycosaminoglycan, proteoglycan, and collagen, which are all key components in the wound healing process. Recent research has shown the promising potential for stem cells to regenerate ECM proteins and functions [14,15]. At the same time, orthobiologics approaches have the potential to facilitate tissue regeneration and repair [16][17][18], and controlling the initiation of the inflammatory response to induce inflammatory cytokines is known to promote angiogenesis [19,20].…”

Section: Introductionmentioning

confidence: 99%

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Mechanobiology-based physical therapy and rehabilitation after orthobiologic interventions: a narrative review

McKay¹,

Nasb

Hafsi³

2021

International Orthopaedics (SICOT)

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Purpose This review aims to summarize the evidence for the role of mechanotherapies and rehabilitation in supporting the synergy between regeneration and repair after an orthobiologic intervention. Methods A selective literature search was performed using Web of Science, OVID, and PubMed to review research articles that discuss the effects of combining mechanotherapy with various forms of regenerative medicine. Results Various mechanotherapies can encourage the healing process for patients at different stages. Taping, bracing, cold water immersion, and extracorporeal shockwave therapy can be used throughout the duration of acute inflammatory response. The regulation of angiogenesis can be sustained with blood flow restriction and resistance training, whereas heat therapy and tissue loading during exercise are recommended in the remodeling phase. Conclusion Combining mechanotherapy with various forms of regenerative medicine has shown promise for improving treatment outcomes. However, further studies that reveal a greater volume of evidence are needed to support clinical decisions.

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Section: Moderate Hyperthermia Inductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Mechanobiology-based physical therapy and rehabilitation after orthobiologic interventions: a narrative review

McKay¹,

Nasb

Hafsi³

2021

International Orthopaedics (SICOT)

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“…Injective treatments can represent an important treatment option to provide clinical improvement through the restoration of joint homeostasis, and possibly disease-modifying effects, in order to avoid or delay operative treatments [8][9][10][11]. Intraarticular injections are minimally invasive procedures: through a direct mode of action, the local administration presents an increased therapeutic effect compared with systemic delivery of drugs such as corticosteroids.…”

Section: Electronic Supplementary Materialsmentioning

confidence: 99%

Evidence on ankle injections for osteochondral lesions and osteoarthritis: a systematic review and meta-analysis

Boffa

Previtali

Frattura

et al. 2020

International Orthopaedics (SICOT)

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Purpose To evaluate the evidence supporting safety and effectiveness of intra-articular injective treatments for ankle lesions ranging from osteochondral lesions of the talus (OLT) to osteoarthritis (OA). Methods A systematic review and a meta-analysis were performed on PubMed, Embase, and Cochrane Library in March 2020. Safety was evaluated through the reported side effects and effectiveness through the scores used. The quality of the studies was assessed using the Cochrane Collaboration Risk of Bias 2.0 tool and the Downs and Black checklist. For each outcome, the quality of evidence was graded according to GRADE guidelines. Results Twenty-four studies (21 for OA, 3 for OLT) were included on hyaluronic acid (HA), platelet-rich plasma (PRP), saline, methylprednisolone, botulinum toxin type A (BoNT-A), mesenchymal stem cells (MSCs), and prolotherapy. No severe adverse events were reported. For OLT, a comparison was possible between HA and PRP showing no significant difference. For ankle OA, a significant difference favouring HA versus saline was documented at six months (p < 0.001). The GRADE level of evidence was very low. Conclusion This meta-analysis supports the safety of intra-articular treatment for ankle OA and OLT, while only a very low evidence supports the efficacy of HA in terms of better results versus placebo for the treatment of ankle OA, and other conclusions are hindered by the scarcity of the available literature. This urges further and stronger trials to specifically investigate potential and limitations of these different injective approaches for the treatment of OLT and ankle OA.Keywords Ankle . Intra-articular . Osteoarthritis . Osteochondral lesions of the talus (OLT) . Hyaluronic acid (HA) . Platelet-rich plasma (PRP)

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“…In all cases we observe clinical improvement, but for the cases when intraarticular injections were performed the pain relieve started earlier and was more prolonged. Though results of intraarticulary injections of hyaluronic acid in some studies are controversial, our clinical experience show improvement after these procedures [23]. As an example we can present a clinical case of patient K, 41 y.o.…”

mentioning

confidence: 94%

Predisposing Factors and Treatment of Osteoarthritis After Surgeries Performed for Tibial Fractures

Dudko

Glubochenko

Pickula

et al. 2019

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Tibial fractures are very common injuries that require surgical management. For many cases, when the fracture involves the joint further complications occur, such as joint stiffness, osteoarthritis, aseptic necrosis of articular surfaces, ankylosis, infection complications, etc. To prevent joint stiffness open reduction and internal fracture fixation is used. That allows better positioning of fracture fragments forming joint surface and improve outcome. The article analyses results of surgical treatment of intraarticular fractures as well as biomechanical factors that are affecting the joint within the healing process and in later outcome period. Various treatment procedures are suggested to prevent development of osteoarthritis or to decrease its severity. The following options are used on all stages of treatment starting since the moment of injury, primary surgical procedures, rehabilitation period, and further non-surgical treatment in the internal medicine department. Important roles are assigned for use of chondroprotective drugs, intraarticular injections of Hyaluronic acid, physiotherapy and physical activity.

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Prevention of post-traumatic osteoarthritis after intra-articular knee fractures using hyaluronic acid: a randomized prospective pilot study

Cited by 8 publications

References 28 publications

Mechanobiology-based physical therapy and rehabilitation after orthobiologic interventions: a narrative review

Mechanobiology-based physical therapy and rehabilitation after orthobiologic interventions: a narrative review

Evidence on ankle injections for osteochondral lesions and osteoarthritis: a systematic review and meta-analysis

Predisposing Factors and Treatment of Osteoarthritis After Surgeries Performed for Tibial Fractures

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