Mechanobiology-based physical therapy and rehabilitation after orthobiologic interventions: a narrative review

McKay, Janine; Nasb, Mohammad; Hafsi, Kholoud

doi:10.1007/s00264-021-05253-5

Cited by 7 publications

(2 citation statements)

References 79 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Despite its potential, however, the field is viewed with significant skepticism by various medical and scientific communities. Reasons for this skepticism include poor documentation, a lack of standardization, vague nomenclature, [40] disorganized research protocols, unsubstantiated recovery protocols, [41] [42] and an absence of a clear understanding of the mechanisms underlying the effects of these therapeutics. All these factors continue to be obstacles in the path towards legitimacy for the field of orthobiologics.…”

Section: Issues On the Road Towards Legitimacymentioning

confidence: 99%

Orthobiologics: An Updated Definition

Sutton¹,

Muran²,

Zaslav³

et al. 2023

OJRM

View full text Add to dashboard Cite

Orthobiologics is a subset of regenerative medicine, which focuses on treating the musculoskeletal system. The main therapeutics utilized include plateletrich plasma, stem cells, exosomes, and scaffolding matrices. Continuous discoveries and new innovations have led to an increase in both popularity and usage of these therapeutics by various medical and scientific communities. Despite its potential, however, the field is viewed with significant skepticism secondary to poor documentation, a lack of standardization, vague nomenclature, disorganized research protocols, and an absence of a clear understanding of the mechanisms underlying the effects of the various therapeutics. This ambiguity led to a surge in direct-to-consumer marketing by "Stem Cell Clinics", putting patient's health at risk and further delegitimizing the field. These shortcomings led to a recent push for standardization by both professionals and organizations alike; a move that has put Orthobiologics on the path toward becoming a guideline-driven, protocol-based, and researchbacked specialty. And with these rapid changes comes the need for an updated definition of "Orthobiologics", a crucial element of any legitimate and standardized medical field.

show abstract

Section: Issues On the Road Towards Legitimacymentioning

confidence: 99%

Orthobiologics: An Updated Definition

Sutton¹,

Muran²,

Zaslav³

et al. 2023

OJRM

View full text Add to dashboard Cite

show abstract

“…Nevertheless, the exploitation of this sensitivity is not part of clinical routine, and, in medical practice only a selected set of specialties make explicit usage of the ability of mechanical stimuli to impinge on yet another EMT (type II) i.e. wound healing: dermatology f or scarring and burning 5 , orthopedics f or bone repair 6 .…”

Section: Introductionmentioning

confidence: 99%

Mechanotransduction and inflammation: an updated comprehensive representation

Suryiagandhi,

Ma,

Paparozzi

et al. 2024

Preprint

View full text Add to dashboard Cite

Mechanotransduction is the process that enables the conversion of mechanical cues into biochemical signaling. While all our cells are well known to be sensitive to such stimuli, the details of the systemic interaction between mechanical input and inflammation are not always well integrated. Often, they are considered and studied in relatively compartmentalized areas, and we therefore argue here that to understand the relationship of mechanical stimuli with inflammation – with high translational potential - it is crucial to offer and analyze a unified view of mechanotransduction. We therefore offer here a pathway representation, recollected with the standard systems biology markup language (SBML) and explored with network biology approaches. We present RAC1 as an exemplar and emerging molecule with potential for medical translation.

show abstract