Prevention of Post-Transfusion Non-A, Non-B Hepatitis by Non-Specific Immunoglobulin in Heart Surgery Patients

Risk and Management of Blood-Borne Infections in Health Care Workers

“…Several studies have attempted to assess the effectiveness of prophylaxis with IG for the prevention of posttransfusion NANB hepatitis. However, the results from these studies are difficult to compare and interpret because of lack of uniformity in diagnostic criteria, varied study designs (including some lacking blinding and control groups), and administration of the first dose of IG prior to rather than after exposure in all but one study (164,231,238). Data from these studies have not been reanalyzed since anti-HCV testing became available.…”

High titers of antibodies inhibiting the binding of envelope to human cells correlate with natural resolution of chronic hepatitis C

“…From the 1 Laboratory of Hepatitis Viruses, Department of Virology II, National Institute of Health, Tokyo, Japan; 2 Chiron Vaccines, Siena, Italy; 3 Department of Gastroenterology, School of Medicine, St. Marianna University, Hiratsuka, Japan; 4 Tokyo National Chest Hospital, Kiyose, Japan; 5 Second Department of Internal Medicine, Shinshu University, School of Medicine, Matsumoto, Japan; and 6 Chiron Vaccines, Emeryville, CA.…”

If You Cannot Grow it, Clone it! Hepatitis C Update

“…Beneficial effects have been observed in most reports (79)(80)(81)(82) but denied in others (83). The antibody detected by the c I00 HCY assay is directed against a nonstructural protein and does not appear to have a neutralizing or protective effect.…”