Prevention of peptic ulcer by aqueous extract of Aegle marmelos leaf in rats

Rahman, Sharmin; Quader, Mohammad Rezaul; Khan, Ismail

doi:10.3329/imcjms.v12i1.35171

Cited by 3 publications

(4 citation statements)

References 2 publications

(2 reference statements)

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“…Extensive experimental and clinical studies prove that Aegle marmelos possess various properties which helped to play a role in prevention and treatment of many diseases [29].…”

Section: Discussionmentioning

confidence: 99%

Studies on Chemotherapeutic Potential of Hydroethanolic Leaf Extract of Aegle marmelos on Human Lung Cancer Cell Lines

Kumar

Sridevi

Selvaraj

et al. 2021

JPRI

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Background: Lung cancer, one of the world’s leading causes of cancer death. There is an improvement in mortality by screening of lung cancer by low dose computed tomography. Long time ago, lung cancer was a reportable disease which now became a commonest cause of death due to cancer. Discovery of medicine for various diseases is still an ongoing process. A lot of diseases are still remaining a threat without any treatment or medicine. Herbal derived medicines are preferred because of their low side effects on patients. Objective: To investigate the role of Aegle marmelos against human lung cancer cell lines (A549 cell line). Materials and Methods: A549 cell lines were procured from NCCS (National center for cell sciences) Pune, India. It was cultured and viability of the cells before and after adding the extract was analysed using the MTT assay. mRNA amplification was done using real time PCR.Statistical analysis was done using ANOVA and dunken’s multiple test. Corresponding graphs are also plotted. Results: The viability of the cells decreased from 100% to 50%. The mRNA expression of wnt and β-catenin decreased after the addition of the extract. Conclusion: The study concluded that Aegle marmelos possesses a good, novel, innovative, anti- cancer activity against the lung cancer cell lines A549.

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“…Extensive experimental and clinical studies prove that Aegle marmelos possess various properties which helped to play a role in prevention and treatment of many diseases [29].…”

Section: Discussionmentioning

confidence: 99%

Studies on Chemotherapeutic Potential of Hydroethanolic Leaf Extract of Aegle marmelos on Human Lung Cancer Cell Lines

Kumar

Sridevi

Selvaraj

et al. 2021

JPRI

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“…Extensive experimental studies have demonstrated that A. marmelos may prevent ulcers and inflammation effectively. An aqueous extract of A. marmelos resulted in decreasing the ulcer score and ulcer index in rats’ stomachs, which was successfully achieved after the administration of 400 mg/kg of an aqueous extract from A. marmelos [ 57 ]. In other studies, ethanol, and an aqueous extract from A. marmelos , provided 56.33% and 37.2% protection of ulcers in vivo and the ethanol-induced gastric ulcer model, respectively, compared to standard drugs such as omeprazole (50.4% protection) (20 mg/kg body weight) [ 57 , 58 ].…”

Section: Plant Mediated Treatment Of Ulcer and Inflammatory Diseasesmentioning

confidence: 99%

“…An aqueous extract of A. marmelos resulted in decreasing the ulcer score and ulcer index in rats’ stomachs, which was successfully achieved after the administration of 400 mg/kg of an aqueous extract from A. marmelos [ 57 ]. In other studies, ethanol, and an aqueous extract from A. marmelos , provided 56.33% and 37.2% protection of ulcers in vivo and the ethanol-induced gastric ulcer model, respectively, compared to standard drugs such as omeprazole (50.4% protection) (20 mg/kg body weight) [ 57 , 58 ]. Ramakrishna et al investigated the effect of the oral administration of methanol extract from unripe A. marmelos in rats against H. pylori LPS-induced gastric ulcers which showed that this extract (500 mg/kg dose) caused a 93.98% reduction in the gastric ulcers [ 59 ].…”

Section: Plant Mediated Treatment Of Ulcer and Inflammatory Diseasesmentioning

confidence: 99%

Therapeutic Promises of Medicinal Plants in Bangladesh and Their Bioactive Compounds against Ulcers and Inflammatory Diseases

Ahmed

Rabbee

Roy

et al. 2021

Plants

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When functioning properly, the stomach is the center of both physical and mental satisfaction. Gastrointestinal disorders, or malfunctioning of the stomach, due to infections caused by various biological entities and physiochemical abnormalities, are now widespread, with most of the diseases being inflammatory, which, depending on the position and degree of inflammation, have different names such as peptic or gastric ulcers, irritable bowel diseases, ulcerative colitis, and so on. While many synthetic drugs, such as non-steroidal anti-inflammatory drugs, are now extensively used to treat these diseases, their harmful and long-term side effects cannot be ignored. To treat these diseases safely and successfully, different potent medicinal plants and their active components are considered game-changers. In consideration of this, the present review aimed to reveal a general and comprehensive updated overview of the anti-ulcer and anti-inflammatory activities of medicinal plants. To emphasize the efficacy of the medicinal plants, various bioactive compounds from the plant extract, their experimental animal models, and clinical trials are depicted.

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“…They concluded that extracts of A. marmelos leaves have potential ability to prevent experimentally induced peptic ulcer formation. 38 Yarasi Gayathri et al (2015) evaluated the antioxidative and antiulcer effect of methanolic extract of unripe fruit of Aegle marmelos against Helicobacter pylori-Lipopolysaccharide induced gastric ulcer in Sprague Dawley rats. Volume of gastric juice, free and total acidity, acid output, pepsin concentration were analyzed and activities of enzymatic antioxidants, non-enzymatic antioxidants and the levels of lipid peroxidation products were also measured.…”

Section: Antibacterial Activity Of Aegle Marmelosmentioning

confidence: 99%

Exploring antibacterial & antiulcer activity of aegle marmelos linn. : A review

Mahato¹

2020

IJPCA

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Antimicrobial drugs are those drugs which are used to treat diseases caused by microorganisms. To treat the diseases caused by pathogenic microorganisms antibiotic, antiviral, antifungal and antiparasitic medicines are used. These microbes produces diseases in humans, animals and plants. According to World Health Organization (WHO). The cases of Antimicrobial resistance (AMR) is increasing day by day and it threatens the effective treatment and prevention of infections caused by bacteria, viruses, fungi and parasites. AMR occurs when these microbes gets resistance against the effects of medications, which makes common infections difficult to treat and hence increases the risk of severe illness, disease spread and death. As a result, the medicines becomes ineffective, infections remains in the body and increases the probability of spread to others. WHO recommends that decreased use of synthetic antibiotics and increased use of herbal antimicrobial drugs are the only ways by which the AMR can be controlled or eliminated. Herbal drugs are considered to be effective and free from side effects. In the present article we discussed about Aegle Marmelos Linn. (Bael) which is useful in treating many health ailments. It possess many pharmacological activities like anticonvulsant, antioxidant, antihyperglycemic, anxiolytic, antidepressant, antihistaminic, antimicrobial, hepatoprotective, analgesic, immune modulatory, cardio protective and antithyroid activity. Due to its antibacterial activity it is used to treat many infections caused by bacteria and also have antiulcer activity due to which it is used to treat ulcer patients. The bacteria, Helicobacter pylori is one of the cause of peptic ulcer. This review article discusses about the effect of Aegle Marmelos on this bacteria.

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Prevention of peptic ulcer by aqueous extract of Aegle marmelos leaf in rats

Cited by 3 publications

References 2 publications

Studies on Chemotherapeutic Potential of Hydroethanolic Leaf Extract of Aegle marmelos on Human Lung Cancer Cell Lines

Studies on Chemotherapeutic Potential of Hydroethanolic Leaf Extract of Aegle marmelos on Human Lung Cancer Cell Lines

Therapeutic Promises of Medicinal Plants in Bangladesh and Their Bioactive Compounds against Ulcers and Inflammatory Diseases

Exploring antibacterial & antiulcer activity of aegle marmelos linn. : A review

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