Prevention of ovarian cancer

Hanna, Louise; Adams, Malcolm

doi:10.1016/j.bpobgyn.2005.10.016

Cited by 44 publications

(36 citation statements)

References 123 publications

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“…Parity also provides protection against endometrial cancer and ovarian cancer in humans as it does for breast cancer (39)(40)(41)(42)(43)(44)(45). We did not find evidence of more macrophages in the rat uterus and ovary of primiparous compared with virgin rats.…”

Section: Discussioncontrasting

confidence: 38%

Parity is associated with an expanded macrophage population in the mammary gland

Zhao

Grubbs²,

Myers³

et al. 2010

Int J Oncol

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Abstract. Pregnancy is a well established protective factor against breast cancer. One explanation for protection is the increased differentiation status of the parous epithelium. However, this does not explain the association of parity with increased aggressiveness of breast cancers, particularly cancers that occur soon after pregnancy. Because tumor aggressiveness can be influenced by the cell population that surrounds the mammary epithelium, we examined the potential role of the immune system in establishing a long-term difference between the mammary glands of primiparous and virgin animals. Specific mRNA levels, enzyme activities and antigen expressing cells were quantified in primiparous and virgin mammary glands from Sprague-Dawley rats in diestrous. Our results show that macrophages, but not neutrophils or B-cells, are specifically increased in fully involuted glands compared with age-matched virgin mammary glands. Macrophages play a dual role in tumor progression, both opposing and supporting the process. Our finding of an increased macrophage population in the primiparous mammary gland could explain the dichotomy of the reported association of parity with decreased breast cancer incidence and increased breast cancer aggressiveness.

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Section: Discussioncontrasting

confidence: 38%

Parity is associated with an expanded macrophage population in the mammary gland

Zhao

Grubbs²,

Myers³

et al. 2010

Int J Oncol

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“…None of the suggested hypotheses so far can explain all the epidemiological data. [1][2][3] According to the latest Monograph on ''Tobacco smoke and involuntary smoking'' from the International Agency for Research on Cancer there is insufficient evidence to draw any conclusions regarding the possible effect of smoking on ovarian cancer risk. 4 Risch et al was the first to suggest that mucinous and nonmucinous ovarian cancer may have different etiology.…”

mentioning

confidence: 99%

Cigarette smoking and risk of borderline and invasive epithelial ovarian cancer

Gram

Br̈aaten

Adami

et al. 2007

Intl Journal of Cancer

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Studies regarding the association between smoking and risk of epithelial ovarian cancer (EOC) are inconsistent. The purpose of this study was to examine the association between smoking and EOC, overall and according to invasiveness and histological subtype in a cohort of women with a high proportion of smokers at enrolment. We followed 103,081 women, aged 30-50 years in 1991/1992, from the Norwegian-Swedish Women's Lifestyle and Health cohort. The women completed a questionnaire on personal characteristics and exposures at enrolment and were subsequently followed with linkages to national registers through December 31, 2004. We used Cox proportional hazard regression models to estimate hazard ratio (RR) of EOC with 95% confidence intervals (CIs) associated with different measures of smoking exposures adjusting for confounding variables.

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“…Annually, 204,000 new cases and 125,000 deaths from ovarian cancer occur in the world (Hanna & Adams., 2006). Our findings are in contrast to developed countries, in where Statistics showed that the mortality from ovarian cancer is declining.…”

Section: Discussionmentioning

confidence: 99%

“…It has a poor prognosis, with five-year survival rates ranging from 26% to 51% in Europe (Sant et al, 2003). Aproximately 10% of ovarian cancer cases are familial (Hanna and Adams, 2006) and the disease is more common in industrialized nations. In the developed countries, ovarian cancer is a common neoplasm, ranking as the 7 th most frequent for incidence (Parkin et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Ovarian Cancer in Iranian Women, a Trend Analysis of Mortality and Incidence

Sharifian

Pourhoseingholi²,

Norouzinia³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: Ovarian cancer is an important cause of mortality in women. The aim of this study was to evaluate the incidence and mortality rates and trends in the Iranian population and make predictions. The general mortality rate of ovarian cancer slightly increased during the years under study from 0.01 to 0.75 and reaching plateau according to the prediction model. Mortality was higher for older age. The incidence also increased during the period of the study. Conclusions: Our study indicated remarkable increasing trends in ovarian cancer mortality and incidence. Therefore, attention to high risk groups and setting awareness programs for women are needed to reduce the associated burden in the future.

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Prevention of ovarian cancer

Cited by 44 publications

References 123 publications

Parity is associated with an expanded macrophage population in the mammary gland

Parity is associated with an expanded macrophage population in the mammary gland

Cigarette smoking and risk of borderline and invasive epithelial ovarian cancer

Ovarian Cancer in Iranian Women, a Trend Analysis of Mortality and Incidence

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