Prevention of new-onset atrial fibrillation after direct myocardial revascularization surgery: randomized comparative study

Nikolayevich, Kolesnikov Vladimir; Игоревна, Боева Ольга; Yagoda, Alexandr; Сергеевна, Иваненко Анна; Danilova, E N; Vladimirovich, Danilov Sergey

doi:10.14300/mnnc.2015.10027

Cited by 4 publications

(8 citation statements)

References 36 publications

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“…Four studies investigated clinical outcomes in patients who were given infusions of FO before cardiac surgery to prevent postoperative complications . Two of these studies reported no significant differences between treatment arms in general postsurgical clinical outcomes .…”

Section: Resultsmentioning

confidence: 99%

“…Two of these studies reported no significant differences between treatment arms in general postsurgical clinical outcomes . Two studies cited a beneficial effect of FO on postoperative atrial fibrillation, but 1 study reported no significant improvement . Of the 2 studies that cited a beneficial effect on atrial fibrillation, 1 did not incorporate a control group treated with an alternative IVLE …”

Section: Resultsmentioning

confidence: 99%

“…Four studies investigated clinical outcomes in patients who were given infusions of FO before cardiac surgery to prevent postoperative complications. 36,43,47,49 Two of these studies reported no significant differences between treatment arms in general postsurgical clinical outcomes. 36,47 Two studies cited a beneficial effect of FO on postoperative atrial fibrillation, 43,49 but 1 study reported no significant improvement.…”

Section: General Clinical Outcomes In Adultsmentioning

confidence: 99%

“…Of these, 13 compared an FOC-IVLE with a SO-based IVLE, [19][20][21][22][24][25][26][28][29][30][42][43][44] 6 with MCT/LCT, 32,33,39,40,45,46 2 with OO, 31,38 3 with placebo or saline, 35,36,47 and 1 with various control emulsions. 48 Three studies included a comparison group that received no intravenous therapy control, [49][50][51] and 1 study supplemented all patients with FO. 52 Mortality.…”

Section: General Clinical Outcomes In Adultsmentioning

confidence: 99%

“…47 Of the 2 studies that cited a beneficial effect on atrial fibrillation, 1 did not incorporate a control group treated with an alternative IVLE. 49 Quality of studies. The quality and strength of evidence for most of the included studies were low, and it is generally not possible to determine whether studies were adequately powered.…”

Section: General Clinical Outcomes In Adultsmentioning

confidence: 99%

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Fish Oil–Containing Lipid Emulsions in Adult Parenteral Nutrition: A Review of the Evidence

Abbasoğlu

Hardy

Manzanares

et al. 2017

J Parenter Enteral Nutr

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Background. There is evidence from laboratory and animal studies that fish oil-containing intravenous lipid emulsions (FOCIVLEs) have a beneficial effect on inflammation and the immune response, suggesting a possible clinical benefit. Clinical studies of FOC-IVLEs have reported mixed results. The aim of this review is to present findings from recent randomized controlled clinical trials and other quality clinical studies investigating the effects of administering intravenous fish oil alone or as part of a multilipid emulsion and to examine the quality of these studies in an objective, evidence-based manner. Methods. Studies comparing FOCIVLEs with other IVLEs in adults were included. Thirty-four clinical studies were evaluated: 19 investigated levels of inflammatory and immune markers as an endpoint; 13 investigated rates of infection or sepsis; 3 investigated clinical outcomes in septic patients; and 29 investigated general clinical outcomes. Results. There was conflicting evidence for a beneficial effect of fish oil on levels of inflammatory and immune markers and some evidence that fish oil decreased the rate of postoperative atrial fibrillation. Studies generally reported few statistical differences in clinical outcomes and rates of infection and sepsis with FOC-IVLEs as compared with other IVLEs. The quality of reporting was generally poor, and the presented evidence for comparisons between FOC-IVLEs and other IVLEs was inconclusive or weak. Conclusions. There is very little high-quality evidence that FOC-IVLEs have a more beneficial effect than other IVLEs on clinical outcomes in adult patients. (JPEN J Parenter Enteral Nutr. 2017;00:1-13)

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: General Clinical Outcomes In Adultsmentioning

confidence: 99%

Section: General Clinical Outcomes In Adultsmentioning

confidence: 99%

Section: General Clinical Outcomes In Adultsmentioning

confidence: 99%

See 3 more Smart Citations

Fish Oil–Containing Lipid Emulsions in Adult Parenteral Nutrition: A Review of the Evidence

Abbasoğlu

Hardy

Manzanares

et al. 2017

J Parenter Enteral Nutr

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Omega-3 polyunsaturated fatty acids in cardiac surgery patients: An updated systematic review and meta-analysis

Langlois

Hardy²,

Manzanares

2017

Clinical Nutrition

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Omega-3 Fatty Acids as Antiarrhythmic Drugs: Upstream Target Modulators Affecting Acute and Long-Term Pathological Alterations in Cardiac Structure and Function

Driscoll,

Welty,

Bistrian

2023

Critical Care Explorations

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OBJECTIVES: Postoperative atrial fibrillation (POAF) is a common complication in the acute care period following coronary artery bypass grafting (CABG) surgery that is associated with significant morbidity and mortality in both short-term and long-term settings. Recently, the Vaughn Williams Classification of antiarrhythmic agents, first proposed in 1975 and widely viewed as the authoritative description of their electrophysiologic actions, was updated and notably omega-3 fatty acids (Ω-3 fatty acids) have been included in class VII, described as “upstream target modulators,” to mitigate pathological structural and electrophysiological remodeling changes in the aged and/or injured myocardium. DATA SOURCES: A PubMed literature search was performed. STUDY SELECTION: Studies examining the significance of complications in patients undergoing isolated CABG surgery were selected for inclusion. DATA EXTRACTION: Relevant data were qualitatively assessed and narratively summarized. DATA SYNTHESIS: POAF occurs in approximately 30% of patients, and inflammation from chronic coronary artery disease preoperatively, as well as acute atrial inflammation from surgery postoperatively are the leading causes. Inflammation underlies its pathophysiology; therefore Ω-3 fatty acids not only exhibit antiarrhythmic properties but are an effective anti-inflammatory treatment that may reduce the clinical risks of POAF. CONCLUSIONS: At present no effective prophylaxis is available to address POAF following CABG surgery. Clinical approaches that focus on the inflammatory response in this setting may optimize the response to treatment. The current literature supports the hypothesis that Ω-3 fatty acids may acutely reduce the inflammatory response via favorable alterations in the metabolism of prostaglandins and leukotrienes (eicosanoids) and specialized pro-resolving mediators.

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Prevention of new-onset atrial fibrillation after direct myocardial revascularization surgery: randomized comparative study

Cited by 4 publications

References 36 publications

Fish Oil–Containing Lipid Emulsions in Adult Parenteral Nutrition: A Review of the Evidence

Fish Oil–Containing Lipid Emulsions in Adult Parenteral Nutrition: A Review of the Evidence

Omega-3 polyunsaturated fatty acids in cardiac surgery patients: An updated systematic review and meta-analysis

Omega-3 Fatty Acids as Antiarrhythmic Drugs: Upstream Target Modulators Affecting Acute and Long-Term Pathological Alterations in Cardiac Structure and Function

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