Prevention of Lactic Acidosis in Cattle by Lasalocid or Monensin

Abstract

Intraruminal administration of lasalocid or monensin (1.3 mg/kg body weight) effectively prevented in glucose- or corn-induced lactic acidosis in cattle. Administering the antibiotics for 7 days before experimentally inducing acidosis with corn (27.5 g/kg body weight), effectively prevented acidosis, while 2 days' were sufficient to prevent glucose-induced acidosis (12.5 g/kg body weight). The different responses observed in the two trials probably stemmed from the difference in amounts of carbohydrate used to induce acidosis. Antibiotic-treated cattle had higher rumen pH values and lower L(+) and D(-) lactate concentrations that control cattle that received no antibiotics. Ruminal VFA in control cattle decreased, while total VFA and the molar proportion of propionate increased in antibiotic-treated cattle after grain engorgement. Control cattle exhibited classic signs of acidosis, such as lowered blood pH; increased blood lactate, particularly D(-) isomer; hemoconcentration, and depleted alkali reserve with a pronounced based deficit. Antibiotic-treated cattle exhibited no signs of systemic acidosis.

Metabolismo oxidativo dos neutrófilos de ovinos tratados com monensina sódica e experimentalmente submetidos à acidose ruminal

“…Trabalhos realizados por Nagaraja et al (1981), Nagaraja et al (1985), Ahuja et al (1990), Bauer et al (1995) e Afonso et al (2000) observaram a eficiência do uso da monensina sódica, da lasalocida e de outros compostos do grupo dos ionóforos na prevenção da acidose láctica em bovinos, bubalinos e ovinos, nos quais verificaram que o pH do líquido ruminal manteve-se elevado e a concentração do ácido láctico baixa, concluindo que o emprego de ionóforos em dietas ricas em carboidratos não-estruturais pode minimizar substancialmente as manifestações clínicas e subclínicas deste distúrbio digestivo.…”

Avaliação da monensina sódica em vacas leiteiras

“…Nas dietas que contém níveis elevados de carboidratos rápidamente fermentáveis, os ionóforos geralmente deprimem o consumo de alimento, porém o ganho de peso não é diminuído e a conversão alimentar é melhorada. Quando bovinos são alimentados com dietas contendo consideráveis quantidades de forragem, os ionóforos não reduzem o consumo, a conversão alimentar é aumentada, porém, com o aumento do ganho de peso (NAGARAJA et al, 1981).…”

The effect of basal diet on lactate-producing bacteria and the susceptibility of sheep to lactic acidosis

“…Several methods are used to reduce the risk of acidosis, including the use of buffers such as sodium bicarbonate (Dunn et al, 1979;Kezar and Church, 1979), inclusion of dietary clays such as bentonite (Huntington et al, 1977;Dunn et al, 1979), the use of antibiotic food additives such as virginiamycin (VM; Godfrey et al, 1995;Rogers et al, 1995) or certain ionophores (Nagaraja et al, 1981 and1985), use of microbial food additives, such as Megasphaera elsdenii , which ferment lactate (Kung and Hession, 1995;Wiryawan and Brooker, 1995) or Saccharomyces cerevisiae (Chaucheyras et al, 1996) as well as the conventional method of gradual introduction of grains. In order to be able to prevent acidosis without further interruption to the fermentation system it is important to identify the rôle of the basal diet with regard to microbial adaptability.…”