Prevention of intra-abdominal adhesion using electrospun PEG/PLGA nanofibrous membranes

Li, Jian; Zhu, Jinhui; He, Ting; Li, Weida; Zhao, Yue; Chen, Zaomei; Zhang, Junhui; Wan, Huaying; Li, Rubing

doi:10.1016/j.msec.2017.04.017

Cited by 47 publications

(36 citation statements)

References 31 publications

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“…Although such layers can reduce the inflammatory response, they lack the sites and microstructures that favour the adhesion and migration of surrounding myoblasts, fibroblasts, and mesothelial cells [11,12]. Seprafilm, genzyme, and polylactide (PLA) are biodegradable solid barrier devices that have been commercialized [13]. These films are difficult to apply, cover the tissue surface with contours, and adhere instantly to any moist surface, including the surgeon's gloves, which makes their handling difficult during laparoscopic surgery [14,15].…”

Section: Introductionmentioning

confidence: 99%

Regenerated silk fibroin (RSF) electrostatic spun fibre composite with polypropylene mesh for reconstruction of abdominal wall defects in a rat model

Yang

Song

Shen

et al. 2020

Artificial Cells, Nanomedicine, and Biotechnology

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Section: Introductionmentioning

confidence: 99%

Regenerated silk fibroin (RSF) electrostatic spun fibre composite with polypropylene mesh for reconstruction of abdominal wall defects in a rat model

Yang

Song

Shen

et al. 2020

Artificial Cells, Nanomedicine, and Biotechnology

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“…Currently biocompatible membranes are being developed using these techniques. [16][17][18] These membranes are more flexible and easier to manipulate in addition they can adhere to the wound without the need for suturing. Dr. Li and his team in 2017 manufactured a membrane using electrospinning of polylactic acid-co-glycolic acid (PLGA) and poly ethylene glycol (PEG).…”

Section: Resultsmentioning

confidence: 99%

Therapeutic alternatives for the prevention of intra peritoneal adhesions

Colón¹,

Nieva

Treviño

et al. 2019

Int J Res Med Sci

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Intestinal adhesions are bands of fibrous tissue created by the intimate contact of two injured surface tissues; these appear in 93% of the patient undergoing intra-abdominal or gastrointestinal surgery. The comorbidities associated with the formation of adhesions have an impact on quality care offered to patients, leading to an increase in healthcare. Goals of this study was to perform a review that includes different therapeutic alternatives in basic and clinical research to prevent the formation of postoperative abdominal peritoneal adhesions. A bibliographic search was conducted in different databases including Pub med, Medline, Cochrane, science direct, from the years 2000 to 2018 using the keywords: gastrointestinal adhesions, small bowel obstruction, prophylaxis, treatment. Only experimental and clinical articles were selected. The development of peritoneal adhesions in most of the experimental studies occurred with cecal abrasion, studying the effect of biodegradable materials, drugs and gels such as mXG Hydrogel. Nanofiber membranes, agents created with recombinant technology such as periostin antisense oligonucleotide and aerosol applications such as polysaccharide 4DryField PH, are positioned to replace in the future the actual limited mechanical barriers application commonly used in abdominal surgery such as seprafilm and interceed. There are several anti-adhesion agents in experimental phase with different mechanism of action that could be used in the short term to prevent the formation of post-surgical intestinal adhesions. The inclusion of gastrointestinal surgeons in basic research is increasing and necessary with multidisciplinary collaboration. It is expected in short term the study and development of a greater number of materials to minimize tissue trauma and decrease the formation of post-surgical adhesions.

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“…Degradable polymers come to mind as a way to meet these requirements. Indeed, many degradable polymers such as polyglycolide, polylactide, and their copolymers are used for the industrial manufacture of implantable medical devices such as surgical sutures, bone fixation devices, drug delivery systems, stents, and scaffolds [21][22][23][24][25]. Degradable stents are also being developed in clinical practice for numerous applications, including vascular applications, which reflects the high level of safety of these devices [24,26].…”

Section: Introductionmentioning

confidence: 99%

From in vitro evaluation to human postmortem pre-validation of a radiopaque and resorbable internal biliary stent for liver transplantation applications

et al. 2020

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The implantation of an internal biliary stent (IBS) during liver transplantation has recently been shown to reduce biliary complications. To avoid a potentially morbid ablation procedure, we developed a resorbable and radiopaque internal biliary stent (RIBS). We studied the mechanical and radiological properties of RIBS upon in vivo implantation in rats and we evaluated RIBS implantability in human anatomical specimens.For this purpose, a blend of PLA50-PEG-PLA50 triblock copolymer, used as a polymer matrix, and of X-ray-visible triiodobenzoate-poly(-caprolactone) copolymer (PCL-TIB), as a radiopaque additive, was used to design X-ray-visible RIBS. Samples were implanted in the peritoneal cavity of rats. The radiological, chemical, and biomechanical properties were evaluated during degradation. Further histological studies were carried out to evaluate the degradation and compatibility of the RIBS. A human cadaver implantability study was also performed.The in vivo results revealed a decline in the RIBS mechanical properties within 3 months, whereas clear and stable X-ray visualization of the RIBS was possible for up to 6 months. Histological analyses confirmed compatibility and resorption of the RIBS, with a limited inflammatory response. The RIBS could be successfully implanted in human anatomic specimens. The results reported in this study will allow the development of trackable and degradable IBS to reduce biliary complications after liver transplantation.

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Prevention of intra-abdominal adhesion using electrospun PEG/PLGA nanofibrous membranes

Cited by 47 publications

References 31 publications

Regenerated silk fibroin (RSF) electrostatic spun fibre composite with polypropylene mesh for reconstruction of abdominal wall defects in a rat model

Regenerated silk fibroin (RSF) electrostatic spun fibre composite with polypropylene mesh for reconstruction of abdominal wall defects in a rat model

Therapeutic alternatives for the prevention of intra peritoneal adhesions

From in vitro evaluation to human postmortem pre-validation of a radiopaque and resorbable internal biliary stent for liver transplantation applications

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