Prevention of human cancer by modulation of chronic inflammatory processes

Ohshima, Hiroshi; Tazawa, Hiroshi; Sylla, Bakary S.; Sawa, Tomohiro

doi:10.1016/j.mrfmmm.2005.03.030

Cited by 151 publications

(114 citation statements)

References 95 publications

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“…This oxidative damage is further implemented by inflammation processes, which is generally induced by UV sunburns. 38 Although, at present, it is difficult to assess how UV is involved in the onset of BRAF mutation, repeated events of intense sun exposure have been correlated with the accumulation of V600E in nevi and melanomas. This mechanism is consistent with our results showing a quantitative association between the sun exposure and the fraction of alleles carrying BRAF V600E .…”

Section: V600ementioning

confidence: 99%

In melanocytic lesions the fraction of BRAFV600E alleles is associated with sun exposure but unrelated to ERK phosphorylation

et al. 2008

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BRAFV600E mutation has been frequently reported in different types of melanocytic lesions, but its role in melanomagenesis is poorly understood, having been associated with either the proliferative-induced MAPK pathway activation or the acquisition of oncogene-driven senescence. The presence of BRAF alterations has been related to sun exposure, although the molecular mechanisms underlying this event are only partly known. To elucidate the relationships among BRAF/NRAS alterations, MAPK pathway activation, and sun exposure, we examined 22 acquired nevi and 18 cutaneus melanomas from 38 patients. Microdissected tissues from each lesion were subjected to BRAF/NRAS mutation analysis by sequencing, allele-specific PCR and pyrosequencing assay. The same lesions were also examined for the expression of phosphorylated ERK1/2. Phototype and an accurate history of sun exposure were evaluated for each patient. BRAF V600E mutation was detected in 50% of the acquired nevi and in 70% of the cutaneus melanomas in the absence of NRAS alterations. The fraction of alleles carrying BRAF V600E substitution was variable but strongly associated with sun exposure. In contrast, no relationship was evidenced between the presence of this mutation and patients' phototype, phosphorylated ERK1/2 expression, or Clark's level. Our findings indicate that in melanocytic lesions, BRAF V600E mutation can affect a subset of the cells and is associated with the type and quantity of sun exposure. This mutation is independent of the nevo-melanoma progression and unrelated to ERK phosphorylation, suggesting that alternative mechanisms to the MAPK activation are also involved in this type of transformation.

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Section: V600ementioning

confidence: 99%

In melanocytic lesions the fraction of BRAFV600E alleles is associated with sun exposure but unrelated to ERK phosphorylation

et al. 2008

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“…6) Such pro-inflammatory cytokines as tumor necrosis factor (TNF)-, interleukin (IL)-1 and IL-6 are also produced by activated macrophages and are involved in the pathogenesis of RA and carcinogenesis. 7,8) Furthermore, cyclooxygenase-2 (COX-2) expression is induced by IL-1 in the synovial tissue of RA patients. 9) PGE 2 produced by COX-2 increases the blood flow and potentiates edema and hyperalgesia.…”

mentioning

confidence: 99%

Oligosaccharides from Agar Inhibit Pro-Inflammatory Mediator Release by Inducing Heme Oxygenase 1

Enoki¹,

Okuda²,

Kudo³

et al. 2010

Bioscience, Biotechnology, and Biochemistry

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“…inducible NOS (iNOS)], mediators of inflammation (e.g. cytokines, COX-2), anti-apoptotic factors, ROS/RNS and xenobiotic-metabolizing enzymes (Ohshima et al, 2005).…”

Section: Resultsmentioning

confidence: 99%

Antitumor and immunomodulatory effects of the naphthoquinone 5-methoxy-3,4-dehydroxanthomegnin

Kitagawa¹,

Vilegas²,

Carlos³

et al. 2011

Rev. bras. farmacogn.

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Large number of quinones has been associated with antitumor, antibacterial, antimalarial and antifungal activities. In this work we describe the effect of the naphthoquinone, 5-methoxy-3,4-dehydroxanthomegnin, on murine tumor cells (LP07 and LM2) and its immunomodulatory effect on nitric oxide (NO) production on LPS-stimulated macrophages. The results have shown that 5-methoxy-3,4-dehydroxanthomegnin was a significant inhibitor of LPS-stimulated NO generation from macrophage (inhibition percentage ranged from 97.4 to 98.9%) and a strong cytotoxic agent against both tumor cells LP07 and LM2 (CI50 6.2±0.36 µM and 74.6±1.9 µM, respectively). These results indicate that the 5-methoxy-3,4-dehydroxanthomegnin may show promising activity in the treatment of murine breast and lung cancer by immunomodulatory and antiproliferative activities.

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Prevention of human cancer by modulation of chronic inflammatory processes

Cited by 151 publications

References 95 publications

In melanocytic lesions the fraction of BRAFV600E alleles is associated with sun exposure but unrelated to ERK phosphorylation

In melanocytic lesions the fraction of BRAFV600E alleles is associated with sun exposure but unrelated to ERK phosphorylation

Oligosaccharides from Agar Inhibit Pro-Inflammatory Mediator Release by Inducing Heme Oxygenase 1

Antitumor and immunomodulatory effects of the naphthoquinone 5-methoxy-3,4-dehydroxanthomegnin

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