Prevention of Hepatitis B Virus Infection and Liver Cancer

Chang, Mei–Hwei

doi:10.1007/978-3-030-57362-1_4

Cited by 10 publications

(10 citation statements)

References 83 publications

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“…63 To put the impact of lifestyle modifications into context, PAFs by important clinical risk factors were estimated. The incidence rate of liver and gastric cancer had been decreasing in China largely thanks to vaccination and antiviral therapy for HBV 64,65 and HP infection. 66 In 2011, an estimated 43.8% of incident liver cancer could be attributed to hepatitis virus infection, while the PAF by smoking, obesity, alcohol, and low vegetable intake was 35.2%.…”

Section: Discussionmentioning

confidence: 99%

Potential Impact of Time Trend of Lifestyle Risk Factors on Burden of Major Gastrointestinal Cancers in China

Giovannucci

2021

Gastroenterology

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Section: Discussionmentioning

confidence: 99%

Potential Impact of Time Trend of Lifestyle Risk Factors on Burden of Major Gastrointestinal Cancers in China

Giovannucci

2021

Gastroenterology

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“…Carcinogenic factors, such as smoking and alcohol use, are risk factors of HBV-related HCC. 25 Both alcohol 26 and insomnia 27 have been reported to influence the hepatic function index recovery. In this study, we found the percentages of patients with smoking or alcohol intake or sleep rhythm reverse showed no significant difference between patients with CVR and PVR, and these factors may not affect virological response during 1-year antiviral treatment.…”

Section: Discussionmentioning

confidence: 99%

“…As described in pharmacokinetics, ETV tablets should be taken on an empty stomach and patients keep fasted at least 2 hours prior and post to administration. [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28] Food causes a negative effect on ETV absorption because it impedes diffusion of the drug to the intestine epithelium surface, leading to decreased bioavailability of ETV. 29 While for TDF, it needs to be taken with food, especially high-fat meal.…”

Section: Discussionmentioning

confidence: 99%

Optimal drug administration manner would rescue partial virological response in chronic hepatitis B patients with entecavir or tenofovir treatment

Tao

Zhang

et al. 2020

Journal of Viral Hepatitis

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Not all treatment‐naïve patients receiving entecavir (ETV) or tenofovir disoproxil fumarate (TDF) therapy can achieve complete virological response, and many factors may be related with the outcome of partial virological response. This study aimed to determine whether the manner of drug administration affects the antiviral efficacy of ETV/TDF monotherapy. All eligible patients were divided into complete or partial response cohorts based on their virological response following 24‐week therapy. Factors related with partial response were evaluated. Patients with partial response were further grouped depending on whether they later adjusted the manner of drug administration, and the antiviral efficacy was compared between the two groups during prolonged treatment. A total of 518 patients were enrolled. Suboptimal drug administration (OR 77.511, P = .000), positive‐HBeAg (OR 3.191, P = .000) and ETV treatment (OR 2.537, P = .001) were identified as independent risk factors for partial response. Among patients with partial response, 213 were in the adjusted group and 76 were in the unadjusted group. The percentages of patients with undetectable serum HBV DNA (78.9% vs 31.6%, P < .001) and with normal alanine aminotransferase (ALT) (88.7% vs 68.4%, P < .001) were both higher in the adjusted group than that in unadjusted group following a further 6‐month therapy. In conclusion, the manner of drug administration is an important factor influencing the efficacy of ETV/TDF therapy, and optimal drug administration manner can help to increase antiviral efficacy and rescue patients with partial response.

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“…While previous studies have elaborated on the four major etiologies of liver cancer, including hepatitis B (LCHB), hepatitis C(LCHC), liver cancer attributed to alcohol use (LCAL), and other causes (LCOT) of liver cancer, in the last few years, liver cancer due to nonalcoholic steatohepatitis (NASH) has gradually gained attention as the fifth leading cause of liver cancer. 3 , 4 , 5 , 6 , 7 , 8 From a global perspective, the etiology of liver cancer can differ drastically from one region to another. For example, in East Asia, infection with hepatitis B and aflatoxin are the predominant causative factors, however, the burden of hepatitis B in Southern Latin America is the lowest.…”

Section: Introductionmentioning

confidence: 99%

Global burden of primary liver cancer by five etiologies and global prediction by 2035 based on global burden of disease study 2019

et al. 2022

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Background: Using data from the global burden of disease (GBD) between 1990 and 2019 to report the leading etiological factors and hazards for liver cancer by HBV (LCHB), HCV (LCHC), alcoholic use (LCAL), NASH (LCNA), and other causes (LCOT). Method:The estimated annual percentage change (EAPC) and age-standardized incidence rate (ASR) in different districts, sex, and age are used to quantify the change of etiologies of liver cancer. Age-period-cohort models were performed to predict the primary liver cancer incidence and case numbers.Results: Based on the GBD database of the whole world for the five etiologies of liver cancer in 2019, the percentage of incidence of LCAL, LCHB, LCHC, LCNA, and LCOT are 18.4%, 41%, 28.5%, 6.8%, and 5.3%, respectively. Fiver etiologies of liver cancer show gender differences, with LCHB and LCAL being more prevalent in men, and LCHC, LCNA being more prevalent in women. Besides, live cancer of males is because of alcohol using and smoking, while the reason of liver cancer of females is drug use, high BMI and high fasting plasma glucose. Interestingly, the incidence of LCHC in women over 85 years old, LCNA in women over 75 years old, and LCOT in women over 75 years old were all higher than that in men.According to the future prediction, the incidence rate of liver cancer itself, as well as the five causes of liver cancer, tends to decrease gradually after 2019, while the incidence rate of LCNA in males will continue to increase until 2025. Conclusions:The incidence of liver cancer has been increasing and its major causes vary considerably at global, regional, or national levels, also vary by gender and age group.

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Prevention of Hepatitis B Virus Infection and Liver Cancer

Cited by 10 publications

References 83 publications

Potential Impact of Time Trend of Lifestyle Risk Factors on Burden of Major Gastrointestinal Cancers in China

Potential Impact of Time Trend of Lifestyle Risk Factors on Burden of Major Gastrointestinal Cancers in China

Optimal drug administration manner would rescue partial virological response in chronic hepatitis B patients with entecavir or tenofovir treatment

Global burden of primary liver cancer by five etiologies and global prediction by 2035 based on global burden of disease study 2019

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