Prevention of H2O2-induced oxidative stress in Chang liver cells by 4-hydroxybenzyl-chitooligomers

Trinh, Mai Duy Luu; Ngo, Dai‐Hung; Tran, Dang-Khoa; Tran, Quoc-Tuan; Vo, Thanh‐Sang; Dinh, Minh-Hiep

doi:10.1016/j.carbpol.2013.12.061

Cited by 17 publications

(7 citation statements)

References 33 publications

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“…The antioxidant activity of the phenol acids grafted N,O-carboxymethyl chitosan increased in order of chitosan ˂ N,O-carboxymethyl chitosan ˂ ferulic acid—N,O-carboxymethyl chitosan ˂ caffeic acid—N,O-carboxymethyl chitosan ˂ gallic acid—N,O-carboxymethyl chitosan [ 58 ]. COS reduce oxidative damage of DNA by inhibiting hydrogen peroxide H 2 O 2 and AAPH radicals [ 59 , 60 , 61 , 62 , 63 ] and block degradation of inhibitory kappa B alpha (IκB-α) protein and translocation of nuclear factor kappa B (NF-κB) [ 63 ]. NF-κB translocates to the nucleus from cytoplasm when activated by stress, bacteria, inflammatory stimuli, cytokines, free radicals, carcinogens, and other agents.…”

Section: Oxidative Stressmentioning

confidence: 99%

The Potential of Chitosan and Its Derivatives in Prevention and Treatment of Age-Related Diseases

Kerch

2015

Marine Drugs

103

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Age-related, diet-related and protein conformational diseases, such as atherosclerosis, diabetes mellitus, cancer, hypercholesterolemia, cardiovascular and neurodegenerative diseases are common in the elderly population. The potential of chitosan, chitooligosaccharides and their derivatives in prevention and treatment of age-related dysfunctions is reviewed and discussed in this paper. The influence of oxidative stress, low density lipoprotein oxidation, increase of tissue stiffness, protein conformational changes, aging-associated chronic inflammation and their pathobiological significance have been considered. The chitosan-based functional food also has been reviewed.

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Section: Oxidative Stressmentioning

confidence: 99%

The Potential of Chitosan and Its Derivatives in Prevention and Treatment of Age-Related Diseases

Kerch

2015

Marine Drugs

103

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“…Therefore, this study was not only designed to investigate whether serum IGF-1 levels could predict the severity and prognosis in patients with sepsis, but we also tried to determine the association between IGF-1 and miRNA-1 in patients. H 2 O 2 has previously been proven to induce oxidative injury in cells (11,12); therefore, …”

Section: Introductionmentioning

confidence: 99%

IGF-1 may predict the severity and outcome of patients with sepsis and be associated with microRNA-1 level changes

Zhang

Liu

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. IGF-1 functions as an anti-oxidative stress molecule and some critical patients with sepsis have a lower level of serum IGF-1. However, the association between IGF-1 and the severity or prognosis of sepsis remains unclear. This study aimed to elucidate the relationship between serum IGF-1 levels and the severity and prognosis of sepsis, and the possible mechanism was analyzed. Clinical characteristics of patients with sepsis were recorded and analyzed. Serum IGF-1 levels and micro (mi)RNA-1 levels were tested using radioimmunoassay and reverse transcription-quantitative polymerase chain reaction (RT-qPCR) analysis, respectively. The A549 cell line and HKC cell line were cultured in vitro and exposed to H 2 O 2 with or without IGF-1 treatment. Cell death was detected by analyzing cell death markers via ELISA kits, and miRNA-1 levels were detected after H 2 O 2 exposure using RT-qPCR analysis. miRNA-1 in cells was upregulated by transfection and IGF-1 mRNA was detected to determine its relationship with miRNA-1. Once again, cell ELISA kits were used to analyze cell death markers after transfection. Serum IGF-1 levels were reduced in patients with sepsis, whereas miRNA-1 levels were higher (P<0.05 vs. healthy control). Patients in the septic shock subgroup or dead patients had the lowest IGF-1 levels and the highest miRNA-1 levels (P<0.05 vs. sepsis and severe sepsis). IGF-1 levels were inversely proportional to the miRNA-1 level. In vitro, IGF-1 reduced the cell death caused by H 2 O 2 . miRNA-1 transfection effectively increased the sensitivity of cells to H 2 O 2 damage by reducing the expression of IGF-1, which was able to prevent cells from injury caused by H 2 O 2 . The transfection of negative control miRNA did not influence the level of IGF-1 miRNA and the sensitivity to H 2 O 2 damage. In conclusion, low IGF-1 levels in patients with sepsis may predict increased severity of the condition and poor prognosis. The possible mechanism is that the excessive miRNA-1 levels reduce IGF-1 levels, resulting in insufficient anti-oxidative action by IGF-1 which increases the injury caused by oxidative stress in patients with sepsis.

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“…Hydrogen peroxide (H 2 O 2 ) has been commonly used to establish an oxidative stress injury model in vitro (with hepatocytes) 5 . ‐ 8 H 2 O 2 induces cytotoxicity by elevating ROS production and causing leakage of lactate dehydrogenase (LDH), subsequently resulting in cell death.…”

Section: Introductionmentioning

confidence: 99%

Carnosic acid protects normal mouse hepatocytes against H₂O₂‐induced cytotoxicity via sirtuin 1‐mediated signaling

Wang

Takikawa

2015

Hepatology Research

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Prevention of H2O2-induced oxidative stress in Chang liver cells by 4-hydroxybenzyl-chitooligomers

Cited by 17 publications

References 33 publications

The Potential of Chitosan and Its Derivatives in Prevention and Treatment of Age-Related Diseases

The Potential of Chitosan and Its Derivatives in Prevention and Treatment of Age-Related Diseases

IGF-1 may predict the severity and outcome of patients with sepsis and be associated with microRNA-1 level changes

Carnosic acid protects normal mouse hepatocytes against H₂O₂‐induced cytotoxicity via sirtuin 1‐mediated signaling

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Prevention of H2O2-induced oxidative stress in Chang liver cells by 4-hydroxybenzyl-chitooligomers

Cited by 17 publications

References 33 publications

The Potential of Chitosan and Its Derivatives in Prevention and Treatment of Age-Related Diseases

The Potential of Chitosan and Its Derivatives in Prevention and Treatment of Age-Related Diseases

IGF-1 may predict the severity and outcome of patients with sepsis and be associated with microRNA-1 level changes

Carnosic acid protects normal mouse hepatocytes against H2O2‐induced cytotoxicity via sirtuin 1‐mediated signaling

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Carnosic acid protects normal mouse hepatocytes against H₂O₂‐induced cytotoxicity via sirtuin 1‐mediated signaling