Prevention of Flares in Children with Atopic Dermatitis with Regular Use of an Emollient Containing Glycerol and Paraffin: A Randomized Controlled Study

Abstract

Regular emollient use in children with mild to moderate AD reduces flares and corticosteroid consumption.

The regular use of an emollient improves symptoms of atopic dermatitis in children: a randomized controlled study

“…The efficacy of emollient creams in reducing xerosis in children with AD has been described previously described . Importantly, treating xerosis improves quality of life in these patients and reduces flares as well as topical corticosteroid consumption . In agreement with these observations, the use of emollient creams is recommended by treatment guidelines …”

“…Primary efficacy results, measured at study completion (i.e. after 12 weeks of treatment), have been already published elsewhere and demonstrated that the regular use of an emollient prevents flares in children with AD . In the present report, we analysed the kinetics of the response over 12 weeks of treatment with these two emollients.…”

“…Treatments were made with products from a same class with documented proofs of efficacy in atopic dermatitis . They were applied according to the product monographs.…”

“…This study aimed to evaluate the benefit of regular use of emollients in the management of mild‐to‐moderate AD. Data regarding primary efficacy endpoints have already been published elsewhere . Both emollients have proven to be more efficient in reducing the percentage of patients with at least one flare during the study compared to children without emollient treatment (35.1% of patients experienced at least one flare in the emollient‐treated group vs. 67.6% in the no emollient group) .…”

“…Both emollients have proven to be more efficient in reducing the percentage of patients with at least one flare during the study compared to children without emollient treatment (35.1% of patients experienced at least one flare in the emollient‐treated group vs. 67.6% in the no emollient group) . In addition, fewer patients treated with emollient required corticosteroids/immunosuppressants compared to patients without emollient treatment (23.6% vs. 43.3%, respectively) . Herein, we specifically assessed whether the regular use of emollients results in a reduction in severity of AD symptoms.…”