Prevention of Epileptic Seizures by Taurine

Idrissi, Abdeslem El; Messing, Jeffrey M.; Scalia, Jason; Trenkner, Ekkhart

doi:10.1007/978-1-4615-0077-3_62

Cited by 103 publications

(52 citation statements)

References 11 publications

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“…Our data showed that melatonin supplementation could prevent the decrease of MMP. It might have occurred as a consequence of the ROS scavenging effect of melatonin (El Idrissi et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

Protective Role of Melatonin and Taurine Against Carbamazepine-induced Toxicity in Freshly Isolated Rat Hepatocytes

2013

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SUMMARY:Carbamazepine is widely used in a broad spectrum of psychiatric and neurological disorders. Idiosyncratic hepatotoxicity is a well-known adverse reaction associated with carbamazepine. Hepatotoxicity is rare, but a real concern when initiating therapy. It was found that oxidative stress is a potential mechanism for carbamazepine-induced hepatotoxicity. Present study evaluated the hepato protective role of taurine and melatonin against carbamazepine-induced hepatotoxicity. Hepatocytes were prepared by the method of collagenase enzyme perfusion via portal vein. Cells were treated with 400 µM carbamazepine, 1mM taurine, and 1mM melatonin. Cell death, reactive oxygen species formation, lipid peroxidation, and mitochondrial membrane depolarization were assessed as toxicity markers and the effects of taurine and melatonin administration on them were investigated. Our results showed that carbamazepine induced oxidative stress; increased ROS formation and lipid peroxidation products and also decreased mitochondrial membrane potential (∆Ψ m ). Carbamazepine caused a decrease in cellular glutathione content and an elevation in oxidized glutathione levels. Our investigation showed that preincubation of hepatocytes with taurine (1 mM) could alleviate oxidative damages induced by carbamazepine; melatonin was also a good antioxidant to protect hepatocytes against cytotoxicity induced by carbamazepine. It may be concluded that taurine and melatonin are effective antioxidants to prevent carbamazepine-induced hepatotoxicity. Following our findings, further studies are suggested on the antioxidant effects of taurine and melatonin in patients receiving carbamazepine.

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Section: Discussionmentioning

confidence: 99%

Protective Role of Melatonin and Taurine Against Carbamazepine-induced Toxicity in Freshly Isolated Rat Hepatocytes

2013

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“…Taurine has failed to inhibit the isoniazid-induced convulsion, suggesting it does not have the ability to inhibit GABA synthesis. Recently, El Idrissi et al [13] have suggested that taurine (43 mg/kg, s.c.) has a significant antiepileptic effect when injected 10 min prior to kainic acid. They claimed that the reduced susceptibility to kainic acid-induced seizures by taurine treatment is due to an activation of GABA receptor in the brain which increases the inhibitory drive through the receptor-associated chloride channel.…”

Section: Discussionmentioning

confidence: 99%

“…Taurine deficiency has been linked to the development of epilepsy and taurine supplementation has an effective inhibitory action [12] , but because of its poor lipid solubility a large quantity for a much longer duration is required. Taurine also plays a role in preventing epileptic seizures [13] . Recently, it has been suggested that taurine has possible anxiolytic effects in anxiety models [14,15] , however the exact mechanism of the anxiolytic action has not been determined yet.…”

Section: Introductionmentioning

confidence: 99%

Taurine Induces Anti-Anxiety by Activating Strychnine-Sensitive Glycine Receptor in vivo

Zhang

Kim²

2007

Ann Nutr Metab

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Taurine has a variety of actions in the body such as cardiotonic, host-defensive, radioprotective and glucose-regulatory effects. However, its action in the central nervous system remains to be characterized. In the present study, we tested to see whether taurine exerts anti-anxiety effects and to explore its mechanism of anti-anxiety activity in vivo. The staircase test and elevated plus maze test were performed to test the anti-anxiety action of taurine. Convulsions induced by strychnine, picrotoxin, yohimbine and isoniazid were tested to explore the mechanism of anti-anxiety activity of taurine. The Rotarod test was performed to test muscle relaxant activity and the passive avoidance test was carried out to test memory activity in response to taurine. Taurine (200 mg/kg, p.o.) significantly reduced rearing numbers in the staircase test while it increased the time spent in the open arms as well as the number of entries to the open arms in the elevated plus maze test, suggesting that it has a significant anti-anxiety activity. Taurine’s action could be due to its binding to and activating of strychnine-sensitive glycine receptor in vivo as it inhibited convulsion caused by strychnine; however, it has little effect on picrotoxin-induced convulsion, suggesting its anti-anxiety activity may not be linked to GABA receptor. It did not alter memory function and muscle activity. Taken together, these results suggest that taurine could be beneficial for the control of anxiety in the clinical situations.

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“…Taurine passes through the blood-brain barrier [26,27,28] and is involved in a variety of physiological processes including neurotransmission [29], membrane stabilization [30], protection against glutamate excitotoxicity [31] and prevention Relation to Well Known Socially Important Diseases of epileptic seizures [32], long-term potentiation in the striatum/hippocampus [33], calcium homeostasis [34], recovery from osmotic shock [35], feedback inhibition of neutrophil/macrophage respiratory burst, adipose tissue regulation and possible prevention of obesity [36,37]. Taurine has an antioxidant effect and plays protective role against various toxic substances (for example lead and cadmium) [38,39,40,41].…”

Section: Taurinementioning

confidence: 99%

Pharmacological Value of Caffeine, Taurine and Arginine in Nutritional Supplements and their Relation to Well Known Socially Important Diseases

Yotova¹

2015

IJNFS

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Email address: M_jotova@mu-pleven Abstract: Caffeine, Taurine and Arginine are one of the most widely used supplements from people of all ages. There are lot of controversial information about their proper use and effects and side effects. Our goal is to determine the reasonable boundaries of using these supplements in healthy people and more important in people with socially important diseases like high blood pressure, diabetes and dementia.

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Prevention of Epileptic Seizures by Taurine

Cited by 103 publications

References 11 publications

Protective Role of Melatonin and Taurine Against Carbamazepine-induced Toxicity in Freshly Isolated Rat Hepatocytes

Protective Role of Melatonin and Taurine Against Carbamazepine-induced Toxicity in Freshly Isolated Rat Hepatocytes

Taurine Induces Anti-Anxiety by Activating Strychnine-Sensitive Glycine Receptor in vivo

Pharmacological Value of Caffeine, Taurine and Arginine in Nutritional Supplements and their Relation to Well Known Socially Important Diseases

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