Prevention of Diabetic Nephropathy

Materson, Barry J.; Preston, Richard A.

doi:10.1080/21548331.1997.11443426

Cited by 9 publications

(3 citation statements)

References 12 publications

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“…Concentration of protein in the filtrate Concentration of protein in the retentate (1) The SC has a value between 0 and 1. A low value for the SC means that less protein passed through the matrix, while a high SC means that more protein passed through the matrix.…”

Section: Sc =mentioning

confidence: 99%

Effect of Cross-Linking on Matrix Permeability: A Model for AGE-Modified Basement Membranes

Boyd-White

Williams

1996

Diabetes

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There is much evidence that basement membranes, such as in the renal glomerulus, act as macromolecular sieves, restricting the passage of proteins. Cross-linking of matrix proteins, as occurs because of advanced glycosylation end products (AGEs) in diabetes, may have an effect on the sieving properties of the basement membrane. To test this hypothesis, Matrigel, a basement membrane-like matrix, was cross-linked with glycolaldehyde and control and cross-linked matrices compared. Control matrices allowed less bovine serum albumin to pass through than did cross-linked matrices, with sieving coefficients (SCs) of 0.38 +/- 0.02 and 0.52 +/- 0.02, respectively (P < 0.0005). The control matrices also allowed less cross-linked albumin through than did the cross-linked matrices: 0.13 +/- 0.01 vs. 0.17 +/- 0.02 (P < 0.002). The SCs of a series of fluorescein isothiocyanate dextrans (four sizes, Mr 16,000- 168,000) were lower for the control matrix than for the cross-linked matrix (P < 0.03). In addition, the SC for glycated albumin (incubated with glucose-6-phosphate) was higher than that of normal albumin for both the control (P < 0.04) and cross-linked matrices (P < 0.001). These data indicate that cross-linking of the matrix increases permeability to macromolecules. Analysis of the data using fiber-matrix theory suggests that the mean fiber radius was increased in the cross-linked matrix. The data also indicate that glycated albumin filters through the matrices more easily than does normal albumin. In relation to the situation seen in vivo, it is possible that glycation of circulating proteins and AGE modification of glomerular basement membrane proteins may both contribute to the proteinuria seen in diabetes.

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Section: Sc =mentioning

confidence: 99%

Effect of Cross-Linking on Matrix Permeability: A Model for AGE-Modified Basement Membranes

Boyd-White

Williams

1996

Diabetes

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“…Angiogenesis is a complex and critical process essential to support the growth of solid tumors could be inducing at the early stages of tumor formation and carcinogesis (Carmeli et al, 2003;Bergers et al, 2003). Angiotensinconverting-enzyme inhibitors (ACE), which Ahmad M. Farag et al is a potent inhibitor of experimental HCC growth and angiogenesis, is associated with the suppression of the Vascular endothelial growth factor (VEGF) at a clinically comparable dose, also markedly suppressed the hepato-carcinogenesis step (Yoshiji et al, 2002).Captopril (D-3-mercapto-2methylpropanoyl-L-proline) is an orally active competitive inhibitor of ACE (Materson and Preston, 1994). Presumably, because of the sulfhydryl group in its molecular structure; Captopril is a potent free radical scavenger and antioxidant (William and Agostino, 1993).…”

Section: Introductionmentioning

confidence: 99%

Impact of vascular endothelial growth factor on prognosis of patients with hepatocellular carcinoma treated with angiotensin-converting-enzyme inhibitors

Farag

Mohamed

smail

et al. 2018

African Journal of Biological Sciences

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Hepatocellular carcinoma (HCC) is the sixth most common cancer and the third leading cause of cancer-related deaths worldwide. Angiotensin-converting-enzyme inhibitors (ACEs) have a role in reducing malignant changes of the liver, and some of ACE inhibitors, such as captopril, inhibited angiogenesis and the growth of induced tumor. ACE inhibitor is associated with the suppression of the vascular endothelial growth factor (VEGF) at a clinically comparable dose, also markedly suppressed the hepato-carcinogenesis step. The present study aimed at evaluating the role of ACE inhibitors on the prognosis of HCC patients who have been treated by captopril.Measurements of liver functions, serum Alfa fetoprotein (AFP ( and VEGF of 40 Egyptian patients with HCC (23 patients with Child-Pugh Band, 17 patients with Child-Pugh C) compared with 8 normal individuals at pre-and post-administration.There was statistically significant decrease of liver functions except serum albumin, serum AFP and VEGF in HCC patients at post administration compared with preadministration. In addition, at pre administration there was significant correlation of serum VEGF with albumin (r = -0.379) and with serum AFP (r = 0.492) and at post administration with albumin (r = -0.492) and with AFP concentration (r = 0.619). The prognostic value of serum AFP and VEGF was assessed by ROC curve showing an AUC of 0.689 and 0.907, respectively for identifying patients with HCC post administration of Captopril.In conclusions the results indicated that ACE inhibitor significantly inhibits tumor growth and angiogenesis along with suppression of the serum VEGF and AFP levels. This may be used in the clinical trials as anti angiogenic agents against cancer, and may be applicable as an anticancer agent providing a new strategy for cancer therapy.

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“…Mesangial cells in the glomerulus respond to glomerular hypertension by producing growth factors, especially tumor necrosis factor-a, which results in increased glomerular permeability, proliferation of glomerular epithelial cells, and excessive production of basement membrane and collagen tissue. These effects eventually lead to glomerular scarring and renal failure (46).…”

Section: Onset Of Diabetic Nephropathymentioning

confidence: 99%

The use of lysosomal enzymuria in the early detection and monitoring of the progression of diabetic nephropathy

Gatsing

Garba

Adoga

2006

Indian J Clin Biochem

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Prevention of Diabetic Nephropathy

Abstract: Normalization of blood pressure--and use of an ACE inhibitor or AT1-receptor blocker for patients with abnormal albumin or creatinine levels--can prevent or significantly slow the rate of progression toward end-stage renal disease.

Cited by 9 publications

References 12 publications

Effect of Cross-Linking on Matrix Permeability: A Model for AGE-Modified Basement Membranes

Effect of Cross-Linking on Matrix Permeability: A Model for AGE-Modified Basement Membranes

Impact of vascular endothelial growth factor on prognosis of patients with hepatocellular carcinoma treated with angiotensin-converting-enzyme inhibitors

The use of lysosomal enzymuria in the early detection and monitoring of the progression of diabetic nephropathy

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