Prevention of dementia in an ageing world: Evidence and biological rationale

Grande, Giulia; Qiu, Chengxuan; Fratiglioni, Laura

doi:10.1016/j.arr.2020.101045

Cited by 116 publications

(102 citation statements)

References 119 publications

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“…The detrimental role of cardiovascular diseases on the brain is well established, being people with heart and cerebrovascular diseases at high risk of developing dementia and with a poor prognosis 4,27 . Indeed, accumulating evidence points toward a close interplay between body and mind in dementia development, 2,28 and our study aligns with this literature. It is notable that we also add weight to such knowledge by reporting that multiple, co‐occurring cardiovascular diseases are linked to dementia.…”

Section: Discussionsupporting

confidence: 86%

“…As a consequence of the worldwide aging of the population, dementia will increasingly become a challenge faced by individuals and societies 1 . Owing to the current lack of curative drugs, dementia prevention has become an especially relevant strategy 2 . As such, the identification of individuals at higher risk of dementia is a clinical and public health priority 3 …”

Section: Introductionmentioning

confidence: 99%

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Multimorbidity burden and dementia risk in older adults: The role of inflammation and genetics

Grande

Marengoni

Vetrano

et al. 2021

Alzheimer's & Dementia

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113

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Introduction We investigate dementia risk in older adults with different disease patterns and explore the role of inflammation and apolipoprotein E (APOE) genotype. Methods A total of 2,478 dementia‐free participants with two or more chronic diseases (ie, multimorbidity) part of the Swedish National study on Aging and Care in Kungsholmen (SNAC‐K) were grouped according to their multimorbidity patterns and followed to detect clinical dementia. The potential modifier effect of C‐reactive protein (CRP) and apolipoprotein E (APOE) genotype was tested through stratified analyses. Results People with neuropsychiatric, cardiovascular, and sensory impairment/cancer multimorbidity had increased hazards for dementia compared to the unspecific (Hazard ration (HR) 1.66, 95% confidence interval [CI] 1.13‐2.42; 1.61, 95% CI 1.17‐2.29; 1.32, 95% CI 1.10‐1.71, respectively). Despite the lack of statistically significant interaction, high CRP increased dementia risk within these patterns, and being APOE ε4 carriers heightened dementia risk for neuropsychiatric and cardiovascular multimorbidity. Discussion Individuals with neuropsychiatric, cardiovascular, and sensory impairment/cancer patterns are at increased risk for dementia and APOE ε4, and inflammation may further increase the risk. Identifying such high‐risk groups might allow tailored interventions for dementia prevention.

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Section: Discussionsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Multimorbidity burden and dementia risk in older adults: The role of inflammation and genetics

Grande

Marengoni

Vetrano

et al. 2021

Alzheimer's & Dementia

Self Cite

113

View full text Add to dashboard Cite

show abstract

“…The prevention of many dementias (vascular dementia, alcohol-related brain damage, head injury) is achievable. 7 Seven challenges then, maybe for seven Royal College of Psychiatrists-led intercollegiate Committees? No, there is a better way.…”

Section: Where Do We Start With Prevention?mentioning

confidence: 99%

Placing poverty-inequality at the centre of psychiatry

Byrne

James

2020

BJPsych Bull

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We examine epidemiological evidence for the central role of inequalities (principally economic) in driving the onset of mental disorders, physical ill health and premature mortality. We locate the search for solutions in current UK contexts, and include known and likely effects of the COVID-19 pandemic. Prevention of mental disorders and adverse outcomes such as premature mortality must begin with efforts to mitigate rising poverty-inequality.

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“…Our society is aging and, with it, the number of diseases of old age, especially dementias, are increasing [ 1 ]. Alzheimer’s disease (AD) is a devastating neurodegenerative disorder and the most common form of dementia worldwide.…”

Section: Introductionmentioning

confidence: 99%

In Vitro and In Vivo Efficacies of the Linear and the Cyclic Version of an All-d-Enantiomeric Peptide Developed for the Treatment of Alzheimer’s Disease

Schemmert

Camargo

Honold

et al. 2021

IJMS

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Multiple sources of evidence suggest that soluble amyloid β (Aβ)-oligomers are responsible for the development and progression of Alzheimer’s disease (AD). In order to specifically eliminate these toxic Aβ-oligomers, our group has developed a variety of all-d-peptides over the past years. One of them, RD2, has been intensively studied and showed such convincing in vitro and in vivo properties that it is currently in clinical trials. In order to further optimize the compounds and to elucidate the characteristics of therapeutic d-peptides, several rational drug design approaches have been performed. Two of these d-peptides are the linear tandem (head-to-tail) d-peptide RD2D3 and its cyclized form cRD2D3. Tandemization and cyclization should result in an increased in vitro potency and increase pharmacokinetic properties, especially crossing the blood–brain-barrier. In comparison, cRD2D3 showed a superior pharmacokinetic profile to RD2D3. This fact suggests that higher efficacy can be achieved in vivo at equally administered concentrations. To prove this hypothesis, we first established the in vitro profile of both d-peptides here. Subsequently, we performed an intraperitoneal treatment study. This study failed to provide evidence that cRD2D3 is superior to RD2D3 in vivo as in some tests cRD2D3 failed to show equal or higher efficacy.

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Prevention of dementia in an ageing world: Evidence and biological rationale

Cited by 116 publications

References 119 publications

Multimorbidity burden and dementia risk in older adults: The role of inflammation and genetics

Multimorbidity burden and dementia risk in older adults: The role of inflammation and genetics

Placing poverty-inequality at the centre of psychiatry

In Vitro and In Vivo Efficacies of the Linear and the Cyclic Version of an All-d-Enantiomeric Peptide Developed for the Treatment of Alzheimer’s Disease

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