Prevention of colorectal cancer in patients with  inflammatory bowel disease

Бикбавова, Г. Р.; Ливзан, М. А.; Fedorin, M. M.

doi:10.18565/pharmateca.2021.7.8-14

Cited by 3 publications

(1 citation statement)

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“…Воспалительные заболевания кишечника (ВЗК) представляет собой хронические рецидивирующие заболевания желудочно-кишечного тракта, которые включают в себя два подтипа: язвенный колит (ЯК) и болезнь Крона (БК). Считается, что ВЗК возникают в результате определенных экологических триггеров у генетически предрасположенных лиц, что приводит к изменению состава и количества микробиоты кишечника и аномальной иммунной воспалительной реакции [1][2][3][4].…”

Section: Introductionunclassified

Risk factors for colorectal cancer in IBD patients

Бикбавова

Livzan

Fedorin

2022

jour

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A characteristic feature of inflammatory bowel diseases (IBD) is an increased risk of neoplasia and colorectal cancer (CRC). The introduction of screening programs, as well as modern advances in therapy and endoscopic technologies, awareness of the risk factors of IBD-associated CRC will contribute to reducing the frequency of this dangerous complication of IBD. The presented review describes epidemiological data on the incidence of IBD-associated CRC, established risk factors for CRC, as well as modern methods of prevention, screening and early diagnosis. Literature search was conducted in PubMed and Google Scholar systems by keywords: inflammatory bowel diseases, ulcerative colitis, Crohn’s disease, colorectal cancer, risk factors, screening, endoscopy, dysplasia.

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Section: Introductionunclassified

Risk factors for colorectal cancer in IBD patients

Бикбавова

Livzan

Fedorin

2022

jour

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Primary prevention of colorectal cancer and technologies for its implementation into practical health care

Levshin,

Slepchenko

2024

Rus. J. Prev. Med.

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Potential role of short-chain fatty acids in irritable bowel syndrome in overweight and obese individuals

Fedorin,

Livzan,

Gaus

et al. 2024

Medicinskij sovet

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Due to increasing prevalence of functional diseases of the colon in obese patients, the mechanisms by which the intestinal microbiota affects the development of symptoms of irritable bowel syndrome (IBS) in the setting of metabolic activity of adipose tissue should be investigated. The quantitative and qualitative changes in the pool of synthesized short-chain fatty acids, which have a multidirectional impact on the colonic motility is one of the key mechanisms by which the intestinal microbiota affects the occurrence and features of the course of irritable bowel syndrome. But as regards the issue of whether individual short-chain fatty acids have an impact on the severity of abdominal pain and characteristics of colonic motility dysfunction, it remains a subject of discussions. The study of the mechanisms of impact of short-chain fatty acids on the development and progression of obesity deserves special attention. Increased serum and faecal short-chain fatty acid levels in obese patients can either be a result of changes in the intestinal microflora composition associated with special eating habits and lifestyle, or have an independent effect on the development of obesity in individuals due to intestinal microflora composition disorders that have been already developed. Due to special features of the course of irritable bowel syndrome associated with overweight and obesity, studying the intestinal microbiota composition and the short-chain fatty acids produced by it in this cohort of IBS patients is of particular interest. This publication has been prepared to describe and systematize the possible mechanisms of impact of short-chain fatty acids on the development of abdominal pain and impaired colonic motility in IBS patients with overweight and obesity. The literature search was conducted in the databases Embase, PubMed and Google Scholar using the keywords “irritable bowel syndrome”, “obesity”, “short-chain fatty acids”, “gut microbiota”.

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Prevention of colorectal cancer in patients with inflammatory bowel disease

Cited by 3 publications

References 0 publications

Risk factors for colorectal cancer in IBD patients

Risk factors for colorectal cancer in IBD patients

Primary prevention of colorectal cancer and technologies for its implementation into practical health care

Potential role of short-chain fatty acids in irritable bowel syndrome in overweight and obese individuals

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