Prevention of cisplatin induced nephrotoxicity by terpenes isolated from Ganoderma lucidum occurring in Southern Parts of India

Pillai, Thulasi G.; Mathew, John; Thomas, Gifty Sara

doi:10.1016/j.etp.2009.11.003

Cited by 30 publications

(21 citation statements)

References 15 publications

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“…7 Experimental studies in animals have revealed that cisplatin nephrotoxicity is associated with significantly higher oxidative stress status and impaired antioxidant status. 31,32 Cisplatin concentration used in the current study does not lead to increase in renal TBARS concentrations or the depletion of renal antioxidant systems when compared with control group. However, cisplatin-treated rats have significantly higher serum TBARs levels.…”

Section: Discussionmentioning

confidence: 74%

Differential effects of grape juice on gastric emptying and renal function from cisplatin-induced acute adverse toxicity

Tsai

Liu

et al. 2016

Hum Exp Toxicol

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Grape skin and seeds contain large amounts of phytochemicals such as polyphenols, resveratrol, and proanthocyanidins, which possess antioxidant activities. Cisplatin is widely used in the treatment of cancer. High doses of cisplatin have also been known to produce acute adverse effects. The aim of this study was to investigate the protective effects of antioxidant properties of whole grape juice (with skin and seeds) on cisplatin-induced acute gastrointestinal tract disorders and nephrotoxicity in Wistar rats. Gastric emptying is significantly increased in whole grape juice-pretreated rats when compared to cisplatin treatment alone. The expression of ghrelin mRNA of stomach is increased in rats with whole grape juice. However, pretreatment with whole grape juice did not reduce renal function markers in acute renal toxicity. No significant changes were recorded in the oxidative stress/antioxidant status parameters of any study group. In contrast, pretreatment with whole grape juice slightly improved tubular cell vacuolization, tubular dilatation, and cast formation in renal tubules. These results show that consumption of whole grape juice induces somewhat beneficial effects in preventing cisplatin-mediated dyspepsia but does not offer protection against cisplatin-induced acute renal toxicity.

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Section: Discussionmentioning

confidence: 74%

Differential effects of grape juice on gastric emptying and renal function from cisplatin-induced acute adverse toxicity

Tsai

Liu

et al. 2016

Hum Exp Toxicol

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“…Results showed that administration of G. lucidum extract resulted in 90% protection of plasmid DNA and prevented 98% of lipid peroxidation. From this study we can conclude that G. lucidum protects the DNA against radiation-induced single-strand breaks and thereby possesses significant radio-protective activity [93].…”

Section: Ganoderma Lucidum In Combination With Other Cancer Treatmentsmentioning

confidence: 96%

“…Swiss albino mice, that were exposed to gamma rays and treated with G. lucidum fruiting-body extracts, were evaluated for radio-protective effects [93]. Results showed that administration of G. lucidum extract resulted in 90% protection of plasmid DNA and prevented 98% of lipid peroxidation.…”

Section: Ganoderma Lucidum In Combination With Other Cancer Treatmentsmentioning

confidence: 99%

“…Another study, performed by Pillai et al (2006), showed that G. lucidum prevents DNA damage induced by radiation. Swiss albino mice, that were exposed to gamma rays and treated with G. lucidum fruiting-body extracts, were evaluated for radio-protective effects [93].…”

Section: Ganoderma Lucidum In Combination With Other Cancer Treatmentsmentioning

confidence: 99%

“…The main side effect of using radiation therapy is DNA damage to the surrounding healthy tissues. Hence, protection of non-cancerous tissues against radiation is vital for reducing the side effects [93]. Many of the recent cytoprotective agents capable of protecting normal tissues against radiation-damage have some undesirable and serious side effects that limit their therapeutic applications [94].…”

Section: Ganoderma Lucidum In Combination With Other Cancer Treatmentsmentioning

confidence: 99%

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Anti-cancer activities of Ganoderma lucidum: active ingredients and pathways

Jesuthasan

Bishop

Glucina³

et al. 2013

FFHD

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Ganoderma lucidum, commonly referred to as Lingzhi, has been used in Asia for health promotion for centuries. The anti-cancer effects of G. lucidum have been demonstrated in both in vitro and in vivo studies. In addition, the observed anti-cancer activities of Ganoderma have prompted its usage by cancer patients alongside chemotherapy.The main two bioactive components of G. lucidum can be broadly grouped into triterpenes and polysaccharides. Despite triterpenes and polysaccharides being widely known as the major active ingredients, the different biological pathways by which they exert their anti-cancer effect remain poorly defined. Therefore, understanding the mechanisms of action may lead to more widespread use of Ganoderma as an anti-cancer agent.The aim of this paper is to summarise the various bioactive mechanisms that have been proposed for the anti-cancer properties of triterpenes and polysaccharides extracted from G. lucidum. A literature search of published papers on NCBI with keywords "Ganoderma" and "cancer" was performed. Among those, studies which specifically examined the anti-cancer activities of Ganoderma triterpenes and polysaccharides were selected to be included in this paper.We have found five potential mechanisms which are associated with the anti-cancer activities of Ganoderma triterpenes and three potential mechanisms for Ganoderma polysaccharides. In addition, G. lucidum has been used in combination with known anti-cancer agents to improve the anti-cancer efficacies. This suggests Ganoderma's bioactive pathways may compliment that of anti-cancer agents. In this paper we present several potential anti-cancer mechanisms of Ganoderma triterpenes and polysaccharides which can be used for the development of Ganoderma as an anti-cancer agent.

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