Differential effects of grape juice on gastric emptying and renal function from cisplatin-induced acute adverse toxicity

Ko, Jiunn‐Liang; Tsai, Cheng-Han; Liu, T.-C.; Lin, Ming-Kuem; Lin, His; Ou, Chu‐Chyn

doi:10.1177/0960327115607079

Cited by 15 publications

(8 citation statements)

References 40 publications

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“…The stability tests of RAH in cancer cells revealed that RAH was hydrolyzed into deacetyl-RAH and subsequently decomposed to release RES and aspirin over 24 h of incubation, suggesting that RAH is able to bear the acidic environment in stomach, avoid enzymatic hydrolysis in small intestine, and incorporate into the colon tissue to perform its antitumor activity. Another study initiated by Ko et al (2016) showed that pretreatment wistar rats with whole grape juice that contains large amounts of RES could induce gastric emptying, improve the tubular dilatation and tubular cell vacuolization in renal tubules, thus bringing beneficial effects in preventing cisplatin-induced gastrointestinal tract disorders.…”

Section: Resultsmentioning

confidence: 99%

A Review of Resveratrol as a Potent Chemoprotective and Synergistic Agent in Cancer Chemotherapy

et al. 2019

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Background: Cancer has become a major disease endangering human health around the world. Conventional chemotherapy suffers from many side effects including pain, cardiotoxicity, hepatotoxicity, and renal toxicity. This review aims to describe a natural product of resveratrol as a chemoprotective and synergistic agent in the modulation of cancer chemotherapy.Methods: The publications were identified by comprehensive searching of SciFinder, PubMed, Web of Science, and our own reference library. Search terms included combinations of “resveratrol,” “cancer,” “natural products,” “chemotherapy,” and “side effects.” Selection of material focused on resveratrol reducing the side effects on cancer chemotherapy.Results: Thirty one references were referred in this review to outline resveratrol as a potent chemoprotective and synergistic agent in cancer chemotherapy, including 22 papers for describing the chemoprotective effects, and 9 papers for illustrating the synergistic effects.Conclusion: This study provides a systematic summary of resveratrol serving as a potent chemoprotective and synergistic agent to reduce the associated-side effects and enhance the therapeutic outcomes in cancer chemotherapy. Further studies in terms of resveratrol on a large amount of preclinical tests and clinical trials are highly demanded.

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Section: Resultsmentioning

confidence: 99%

A Review of Resveratrol as a Potent Chemoprotective and Synergistic Agent in Cancer Chemotherapy

et al. 2019

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“…In another study, Ko et al evaluated the effect of a whole grape juice (with skin and seeds) in rats treated with cisplatin, a chemotherapeutic drug known to provoke acute GI disorders. Cisplatin treatment decreased significantly the rate of gastric emptying compared with the control group, and pretreatment with grape juice (10 ml/kg body weight) prevented this disturbance (68). …”

Section: Pacs In the Stomachmentioning

confidence: 98%

The Gastrointestinal Tract as a Key Target Organ for the Health-Promoting Effects of Dietary Proanthocyanidins

et al. 2017

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Proanthocyanidins (PACs) are polymers of flavan-3-ols abundant in many vegetable foods and beverages widely consumed in the human diet. There is increasing evidence supporting the beneficial impact of dietary PACs in the prevention and nutritional management of non-communicable chronic diseases. It is considered that PACs with a degree of polymerization >3 remain unabsorbed in the gastrointestinal (GI) tract and accumulate in the colonic lumen. Accordingly, the GI tract may be considered as a key organ for the healthy-promoting effects of dietary PACs. PACs form non-specific complexes with salivary proteins in mouth, originating the sensation of astringency, and with dietary proteins, pancreatic enzymes, and nutrient transporters in the intestinal lumen, decreasing the digestion and absorption of carbohydrates, proteins, and lipids. They also exert antimicrobial activities, interfering with cariogenic or ulcerogenic pathogens in the mouth (Streptococcus mutans) and stomach (Helicobacter pylori), respectively. Through their antioxidant and antiinflammatory properties, PACs decrease inflammatory processes in animal model of gastric and colonic inflammation. Interestingly, they exert prebiotic activities, stimulating the growth of Lactobacillus spp. and Bifidobacterium spp. as well as some butyrate-producing bacteria in the colon. Finally, PACs are also metabolized by the gut microbiota, producing metabolites, mainly aromatic acids and valerolactones, which accumulate in the colon and/or are absorbed into the bloodstream. Accordingly, these compounds could display biological activities on the colonic epithelium or in extra-intestinal tissues and, therefore, contribute to part of the beneficial effects of dietary PACs.

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“…Rather, after pre-treatment with whole grape juice tubular cell vacuolization, tubular dilatation and cast formation in kidney tubules were observed to be slightly improved. 37…”

Section: Grapementioning

confidence: 99%

Potential of Pure Phytoconstituents and Herbs in Protection of Drug Induced Nephrotoxicity

Insaf¹,

Raju²

2019

IJPER

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Global trend is setting towards improved 'quality of life', for that there is considerable evidence of an increase in demand for medicinal plants. According to the WHO report, between 65% and 80% of the populations of developing countries use medicinal plants as remedy nowadays. Kidney is one of the vital organs of body and Nephrotoxicity is one of the most common problems and it occurs as a result when body is exposed to a drug or toxin. This review article aims to report and to introduce the effect of most important medicinal herbs, herbal formulations and some of the specific phytoconstituents that are used to prevent and treat anticancer, aminoglycoside, non-steroidal anti-inflammatory and few other classes of drug-induced nephrotoxicity. Particularly anti-cancer drugs among all other classes of drugs, cause high toxicity leading kidney damage and irreparable kidney injury. So, attention has recently been paid to seek out alternatives such as natural drugs that are effective and also less toxic. According to the studies carried out on different animals and cell line, many medicinal plants, herbal formulations and a few plant-based constituents by their antioxidant, free-radical and anti-inflammatory properties are found to be helpful in preventing drug-induced nephrotoxicity.

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Differential effects of grape juice on gastric emptying and renal function from cisplatin-induced acute adverse toxicity

Cited by 15 publications

References 40 publications

A Review of Resveratrol as a Potent Chemoprotective and Synergistic Agent in Cancer Chemotherapy

A Review of Resveratrol as a Potent Chemoprotective and Synergistic Agent in Cancer Chemotherapy

The Gastrointestinal Tract as a Key Target Organ for the Health-Promoting Effects of Dietary Proanthocyanidins

Potential of Pure Phytoconstituents and Herbs in Protection of Drug Induced Nephrotoxicity

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