A Review of Resveratrol as a Potent Chemoprotective and Synergistic Agent in Cancer Chemotherapy

Abstract

Background: Cancer has become a major disease endangering human health around the world. Conventional chemotherapy suffers from many side effects including pain, cardiotoxicity, hepatotoxicity, and renal toxicity. This review aims to describe a natural product of resveratrol as a chemoprotective and synergistic agent in the modulation of cancer chemotherapy.Methods: The publications were identified by comprehensive searching of SciFinder, PubMed, Web of Science, and our own reference library. Search terms included combinations of “resveratrol,” “cancer,” “natural products,” “chemotherapy,” and “side effects.” Selection of material focused on resveratrol reducing the side effects on cancer chemotherapy.Results: Thirty one references were referred in this review to outline resveratrol as a potent chemoprotective and synergistic agent in cancer chemotherapy, including 22 papers for describing the chemoprotective effects, and 9 papers for illustrating the synergistic effects.Conclusion: This study provides a systematic summary of resveratrol serving as a potent chemoprotective and synergistic agent to reduce the associated-side effects and enhance the therapeutic outcomes in cancer chemotherapy. Further studies in terms of resveratrol on a large amount of preclinical tests and clinical trials are highly demanded.

The Plant-Derived Compound Resveratrol in Brain Cancer: A Review

“…RES has been further studied for its increasing relevance in various neurological disorders, such as Alzheimer's [86][87][88], Parkinson's [89,90], and other neurodegenerative diseases [91,92], as well as brain tumors [93][94][95]. In addition, RES showed anticancer activity in many other cancer types, such as breast, prostate, skin, lung, liver, or colorectal cancer, as reviewed, for example, in [45,[96][97][98].…”

“…Numerous studies have shown that RES is able to alleviate the side effects induced by chemotherapeutic drugs [98,134]. Moreover, in combination with other anticancer agents, RES synergistically or additively enhances their efficacy against various types of cancer [135].…”

Inclusion of the Phytoalexin trans-Resveratrol in Native Cyclodextrins: A Thermal, Spectroscopic, and X-Ray Structural Study

“…Trans-resveratrol (trans-3,5,4 -trihydroxystilbene, RSV) ( Figure 1) is a triphenolic phytoalexin with potent antioxidant activity and is found in a variety of plant species, such as grapevines, mulberries, peanuts, and the dried roots and stems of Japanese knotweed (Polygonum cuspidatum). An increasing volume of research on RSV has revealed its diverse range of biomedical properties, which may indicate its use for the treatment of a variety of human diseases [1][2][3][4][5].…”

<p>Resveratrol Reverses Cigarette Smoke-Induced Urocystic Epithelial–Mesenchymal Transition via Suppression of STAT3 Phosphorylation in SV-HUC-1-Immortalized Human Urothelial Cells</p>

“…Resveratrol has a variety of pharmacological effects including anti-inflammatory and antioxidant activities, along with inhibiting cancer growth and invasion. 13 In ovarian cancer, resveratrol inhibits cell survival in a time-dosedependent manner and is less toxic to normal cells. 14 A large number of studies have shown that resveratrol inhibits the initiation and progression of various tumors including breast cancer, prostate cancer, ovarian cancer, liver cancer, and lung cancer.…”