Prevention of Cisplatin-Induced Acute Kidney Injury: A Systematic Review and Meta-Analysis

Hamroun, Aghilès; Lenain, Rémi; Bigna, Jean Joël; Speyer, Élodie; Bui, Linh; Chamley, Paul; Pottier, Nicolas; Cauffiez, Christelle; Dewaeles, Edmone; Dhalluin, X.; Scherpereel, Arnaud; Hazzan, Marc; Maanaoui, Mehdi; Guilhot, François

doi:10.1007/s40265-019-01182-1

Cited by 59 publications

(45 citation statements)

References 91 publications

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“…8 The protective effects of Mg to against cisplatin-induced nephrotoxicity were proposed in previous reports. 22,23 Hamroun et al confirmed the benefit of magnesium administration to reduct the cisplatininduced acute renal toxicity. 22 Besides, radiocontrast agents used in interventional therapy could harm the kidney by disturbing tubulodynamics and glomerular filtration, bringing out hypoperfusion and hypoxia.…”

Section: Discussionmentioning

confidence: 98%

“…22,23 Hamroun et al confirmed the benefit of magnesium administration to reduct the cisplatininduced acute renal toxicity. 22 Besides, radiocontrast agents used in interventional therapy could harm the kidney by disturbing tubulodynamics and glomerular filtration, bringing out hypoperfusion and hypoxia. 24 Our previous study confirmed electrolyte disturbance accompanied AKI occurrence by pointing out hyponatremia and hypokalemia were the independent risk factors for AKI (aOR=2.84 and 2.42) in patients with malignancy.…”

Section: Discussionmentioning

confidence: 98%

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<p>The Effect of Admission Serum Magnesium on the Acute Kidney Injury Among Patients with Malignancy</p>

Shen¹,

Wang²,

Xu³

et al. 2020

CMAR

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This study aimed to explore the relationship between serum magnesium (Mg) levels and incidence of acute kidney injury (AKI) in patients with malignancy. Patients and Methods: Hospitalized patients with malignancy between October 1, 2014 and September 30, 2015 in Zhongshan Hospital were recruited. All relevant data were extracted from the electronic database. Results: All 99,845 patients were enrolled and 16,082 eligible patients were divided into three groups according to admission serum Mg levels in this study. Among them, 2383 (14.8%) cases were diagnosed as AKI. The incidence of AKI showed a V trend with the increase of serum Mg level. The effect of low serum Mg level on the onset of AKI seems to be greater than high serum Mg level. Patients with low serum Mg level spent a longer time in the hospital than those with normal serum Mg level and high serum Mg level. Further, multivariate logistic regression model was used to assess the importance of serum Mg level to influence AKI incidence. There was a higher AKI incidence in patients with magnesium level 0.66mmol/L or less (aOR=2.438, 95% CI=1.696, 3.505). Conclusion: Low serum Mg level might be a independent risk factor for AKI in patients with malignancy. Appropriate clinical intervention for serum Mg disorder may contribute to decreasing the incidence of AKI and the possibility of poor outcomes in cancer patients.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 98%

<p>The Effect of Admission Serum Magnesium on the Acute Kidney Injury Among Patients with Malignancy</p>

Shen¹,

Wang²,

Xu³

et al. 2020

CMAR

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“…Magnesium shows the preventive effect on cisplatin-induced acute kidney injury in patients ( Hamroun et al, 2019 ; Solanki et al, 2014 , 2015 ). A retrospective analysis of 3828 patients has demonstrated that magnesium sulfate supplement, as a co-adjuvant drug during the period of major laparoscopic abdominal surgery, reduces a risk of postoperative acute kidney injury ( Oh et al, 2019 ).…”

Section: Therapeutic Application Of Magnesium In Other Diseasesmentioning

confidence: 99%

“…Thus, magnesium deficiency may be one of the reasons for the further deterioration of COVID-19 patient's condition. Magnesium supplementation plays a beneficial role in improving acute kidney injury ( Barbosa et al, 2016 ; Hamroun et al, 2019 ; Solanki et al, 2015 ), controlling blood glucose in diabetic patients ( Soliman and Nofal, 2019 ). Therefore, we recommend that serum magnesium level in COVID-19 patients with other coexisting disorders should be monitored.…”

Section: The Possibility Of the Use Of Magnesium Supplementation In Tmentioning

confidence: 99%

Possibility of magnesium supplementation for supportive treatment in patients with COVID-19

Tang

Ding

Jiao

et al. 2020

European Journal of Pharmacology

100

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Magnesium as an enzymatic activator is essential for various physiological functions such as cell cycle, metabolic regulation, muscle contraction, and vasomotor tone. A growing body of evidence supports that magnesium supplementation (mainly magnesium sulfate and magnesium oxide) prevents or treats various types of disorders or diseases related to respiratory system, reproductive system, nervous system, digestive system, and cardiovascular system as well as kidney injury, diabetes and cancer. The ongoing pandemic coronavirus disease 19 (COVID-19) characterized by respiratory tract symptoms with different degrees of important organ and tissue damages has attracted global attention. Particularly, effective drugs are still lacking in the COVID-19 therapy. In this review, we find and summarize the effectiveness of magnesium supplementation on the disorders or diseases, and provide a reference to the possibility of magnesium supplementation for supportive treatment in patients with COVID-19.

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“…The following patient information during hospitalization was documented: sex, age, type of cancer, chemotherapy regimen, performance status, hemoglobin, glycated hemoglobin, serum albumin, estimated glomerular filtration rate (eGFR), serum creatinine (SCr), mean blood pressure, body mass index (BMI), C-reactive protein, the dose of cisplatin, the volume of hydration after the cisplatin administration in the same day, concurrent radiation therapy, and drugs associated with kidney function such as nonsteroidal anti-inflammatory drugs, magnesium, mannitol, renin-angiotensin system inhibitor and organic cation transporter 2 inhibitor (histamine H2 receptor antagonist or proton pump inhibitor) [14][15][16].…”

Section: Data Collectionmentioning

confidence: 99%

Effect of dipeptidyl peptidase-4 inhibitors on cisplatin-induced acute nephrotoxicity in cancer patients with diabetes mellitus: A retrospective study

et al. 2020

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Background Cisplatin is a highly effective chemotherapeutic agent. However, acute kidney injury (AKI) limits its subsequent use, resulting in poor cancer prognosis. Dipeptidyl peptidase-4 (DPP-4) inhibitors have been reported to attenuate cisplatin-induced AKI in animal models, but the effect in human patients remains to be clarified. We hypothesized that DPP-4 inhibitors can prevent cisplatin-induced AKI in diabetic-cancer patients. Methods We retrospectively reviewed all consecutive cancer patients who were treated with a first cycle of cisplatin-containing regimen between January 2011 and October 2019. We analysed data of diabetic-cancer patients treated with high-dose cisplatin (> 50 mg/m 2)-containing regimens. The change of estimated glomerular filtration rate (eGFR) within 2 weeks after cisplatin treatment was compared between the patients treated with DPP-4 inhibitors and those treated without DPP-4 inhibitors. Results A total of 455 patients were treated with cisplatin during the period. Of these, 34 patients were eligible for the analysis. The change of eGFR was significantly less in the patients treated with DPP-4 inhibitors, compared to those without DPP-4 inhibitors [the percentages of eGFR decline (mean ± SD) was 23.6 ± 20.3% vs 43.1± 20.1%, respectively; P = 0.010]. Furthermore, the incidence of AKI was significantly less in the patients treated with DPP-4 inhibitors (25% vs 64%, respectively; P = 0.026). Conclusions DPP-4 inhibitors may decrease the risk of cisplatin-induced AKI in diabetic patients.

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Prevention of Cisplatin-Induced Acute Kidney Injury: A Systematic Review and Meta-Analysis

Cited by 59 publications

References 91 publications

<p>The Effect of Admission Serum Magnesium on the Acute Kidney Injury Among Patients with Malignancy</p>

<p>The Effect of Admission Serum Magnesium on the Acute Kidney Injury Among Patients with Malignancy</p>

Possibility of magnesium supplementation for supportive treatment in patients with COVID-19

Effect of dipeptidyl peptidase-4 inhibitors on cisplatin-induced acute nephrotoxicity in cancer patients with diabetes mellitus: A retrospective study

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