Prevention of cancer: Vegetables and plants

G, Hocman

doi:10.1016/0305-0491(89)90070-9

Cited by 42 publications

(23 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Antimutagenic properties are inherent to antioxidants, superoxide dismutase (SOD), catalase, GSH-peroxidase,~-carotin, oe-tocopherol, vitamin C, uric acid (major antioxidant in saliva) and many other substances, sorne of which are mentioned in the reviews by Hocman (1988) and Hartman and Shankel (1990). Antimutagenicity is detected for more than 300 chemicals, mostly of vegetable and animal origin and sorne synthesized chemically.…”

Section: Introductionmentioning

confidence: 99%

Antimutagenic and reactivative activities of dairy propionibacteria

Vorobjeva

Khodjaev

Cherdinceva

1995

Lait

View full text Add to dashboard Cite

Summary -Cells of Propionibacterium freudenreichii subsp shermanii lower the mutagenicity of 4-nitroquinoline-1-oxide in the tester strain Salmonella typhimurium TA 100 in the modified Ames test. The bacterial adaptation to the mutagen presence in the medium is demonstrated. It is possibly Iinked to induction of an antimutagenic activity. A dialysed fraction of soluble proteins of the extract (dialysate) lowers the mutagenicity of UV-C light in Salmonella typhimurium and manifests protective and reactivative effects on UV-B-and UV-C-irradiated cells of S typhimurium, Escherichia coli and the yeast Candida guilliermondii. The reactivation does not occur alter the cell irradiation with a light of total optical spectrum and visible light. (The last was studied with the yeasts.) These data serve as an indirect indication of the dialysate proteins participation in the repair of DNA injured by UV-B and UV-C irradiation. The reactivation by dialysate occurs in E coli and the yeasts Saccharomyces cerevisiae and C guilliermondii, inactivated by heating. The reactivative activity of the dialysate was localized in its 2 subfractions that manifests in E coli inactivated not only by UV light but also by heating.

show abstract

Section: Introductionmentioning

confidence: 99%

Antimutagenic and reactivative activities of dairy propionibacteria

Vorobjeva

Khodjaev

Cherdinceva

1995

Lait

View full text Add to dashboard Cite

show abstract

“…There have been considerable scientific evidence, epidemiology and experimental, accumulated in these years indicating that a large number of plants, fruits, vegetables and other dietary substances possess efficacy to act as cancer preventive agents (Hickman, 1989, Steinmetz and Potter 1991, Rao et al, 1990. In light of this chemopreventive potential of A. adcendens root have been discussed which is mainly because of the antioxidant potential of the plant.…”

Section: Plants As Source Of Antioxidantsmentioning

confidence: 99%

Antioxidant Potential of Asparagus adscendens

Singh¹,

Shrivastava²,

Kale³

2012

Antioxidant Enzyme

View full text Add to dashboard Cite

“…Among them, seaweeds have been used as an important dietary component in Asian communities. Previous results have shown that extracts of various edible seaweeds have protective factors against some types of cancer and that they exhibit suppressive effects against chemically induced tumorigenesis through suppression at the initiation and promotion phases (16)(17)(18)(19). Of these, Laminaria japonica, a brown alga, is the most important economic seaweed cultured in the temperate seaside areas of the northwest Pacific, including Korea, Japan, and China.…”

Section: Introductionmentioning

confidence: 99%

Apoptosis induction by glycoprotein isolated from Laminaria japonica is associated with down-regulation of telomerase activity and prostaglandin E2 synthesis in AGS human gastric cancer cells

Han

Kim²,

Moon³

et al. 2011

Int J Oncol

View full text Add to dashboard Cite

Abstract. Glycoprotein isolated from Laminaria japonica (LJGP) is known to exhibit significant cytotoxic activity against human cancer cells; however, the mechanisms of its cytoxicity are poorly understood. In this study, we investigated further possible mechanisms by which LJGP exerts its anti-cancer action in cultured human gastric carcinoma AGS cells. LJGP treatment of AGS cells resulted in inhibition of growth and induction of apoptosis in a time-and concentrationdependent manner, as determined by MTT assay, fluorescence microscopy, and flow cytometry analysis. The increase in apoptosis was associated with up-regulation of pro-apoptotic Bax expression, down-regulation of anti-apoptotic Bcl-2 and IAP family members, and activation of caspase-3 and -9. LJGP treatment markedly down-regulated the activity of telomerase and expression of human telomerase reverse transcriptase, a main determinant of telomerase enzymatic activity, with inhibition of Sp1 and c-Myc expression in a concentration-dependent manner. Furthermore, LJGP treatment also caused a progressive decrease in the expression levels of cyclooxygenase (COX)-2 without significant changes in the levels of COX-1, which was correlated with a decrease in prostaglandin E 2 synthesis. These results provide important new insights into the possible molecular mechanisms of the anti-cancer activity of LJGP.

show abstract

Prevention of cancer: Vegetables and plants

Cited by 42 publications

References 49 publications

Antimutagenic and reactivative activities of dairy propionibacteria

Antimutagenic and reactivative activities of dairy propionibacteria

Antioxidant Potential of Asparagus adscendens

Apoptosis induction by glycoprotein isolated from Laminaria japonica is associated with down-regulation of telomerase activity and prostaglandin E2 synthesis in AGS human gastric cancer cells

Contact Info

Product

Resources

About