Antioxidant Potential of Asparagus adscendens

Singh, Manju; Shrivastava, Divya; Kale, R.K.

doi:10.5772/52983

Cited by 4 publications

(5 citation statements)

References 86 publications

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“…This can be interpreted as a tumor having high levels of OS, and then, the levels of the body's antioxidant system increase correspondingly to compensate for the increased ROS levels as a natural defense against cancer [ 50 ]. When homeostasis is disturbed, lipid peroxides escape detoxification and produce toxic aldehydes, the most famous of which is malondialdehyde [ 51 ]. Moreover, high levels of ROS accumulation are shown to be closely related to programmed cell death.…”

Section: Discussionmentioning

confidence: 99%

Expression of eIF4E Gene in Glioma and Its Sensitivity to Oxidative Stress

Liang

Yang

et al. 2022

Oxidative Medicine and Cellular Longevity

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Objective. Increased expression of eIF4E has been observed in various cancers, which makes eIF4E an attractive target of anticancer drugs. This study mainly discussed eIF4E gene expression in glioma and its sensitivity to oxidative stress (OS). Methods. Relevant data from The Cancer Genome Atlas (TCGA) database regarding eIF4E gene expression and its prognostic significance in glioma samples were analyzed. Additionally, we measured eIF4E at mRNA and protein levels in clinical samples collected between July 2019 and September 2021, as well as glioma cell strains. U251 cells cultured in vitro were treated with OS injury induced by hydrogen peroxide (H2O2) and then transfected with si-eIF4E to determine changes in cell multiplication, invasiveness, and migration capacities as well as apoptosis rate. ELISA quantified cell malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) concentrations, and flow cytometry measured reactive oxygen species (ROS) level. Results. In glioma samples from the TCGA database, eIF4E showed obviously elevated levels in LGG and GBM patients, which was usually associated with adverse patient prognosis ( P < 0.05 ). eIF4E was also upregulated in glioma cell strains than in HBE cells. In comparison with the blank control group, transfection of si-eIF4E statistically suppressed the capacity of U251 cells to proliferate, invade and migrate, and enhance apoptosis rate, while reducing SOD and GSH-Px and increasing MDA and ROS. In addition, H2O2 induced the upregulation of eIF4E in U251 cells. H2O2 + si-eIF4E exhibited reduced multiplication and number of clone cell formation, invasion, and migration of U251 cells, as well as increased apoptosis rate than H2O2 + si-NC group. Conclusions. eIF4E is highly expressed in glioma. Knocking down eIF4E can effectively inhibit the capacity of U251 to proliferate, invade and migrate, and significantly increase apoptosis. In addition, eIF4E knock-down is able to lower OS reaction under H2O2 inducement and enhance U251 cells’ sensitivity to OS.

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Section: Discussionmentioning

confidence: 99%

Expression of eIF4E Gene in Glioma and Its Sensitivity to Oxidative Stress

Liang

Yang

et al. 2022

Oxidative Medicine and Cellular Longevity

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“…The effect of antioxidant enzymes (catalase, superoxide, dismutase) was also increased due to the diet containing Musali. 31 3. Anti-fertility activity: It was found to have 28% anti-fertility activity in albino rats when its seed powder was used along with equal quantity of gum acacia at dose of 175mg/Kg administered daily.…”

Section: Tuber Contentsmentioning

confidence: 99%

Traditional uses, Phytochemistry and Pharmacology of Asparagus adscendens Roxb.: A Review

Das,

Kumari Gupta,

Raut

et al. 2024

Journal of Ayurveda Campus

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Background: Musali (Asparagus adscendens Roxb.) is a traditionally important medicinal plant of the family Asparagaceae. It is used worldwide to treat several ailments due to the presence of various bioactive constituents, mainly concentrated in the tubers of plants. It has been used since time immemorial as a popular drug for treating chronic leucorrhea, spermatorrhea, general weakness, diarrhea, dysentery, and pharmacological purposes like rejuvenation, aphrodisiac, etc. This review aimed to gather information on the traditional uses, phytochemistry, and pharmacology of Asparagus adscendens Roxb. Materials and methods: Primarily, classical literatures of Ayurveda, including Brihat-trayi (greater triad), Laghu-trayi (lesser triad), and Nighantus (lexicons), were reviewed for the terms “Musali” and “Shweta Musali.". Establishing an overview, library resources, and online collections of books and original research articles, other online databases such as Pubmed Central, Scopus, Embase, Web of Science, ERIC, IEEE Xplore, ScienceDirect, DOAJ, JSTOR, Henari, Google Scholar, and NepJoL were explored with search words like “Musali”, “Safed Musali”, “Shweta Musali” “Asparagus adscendens”, botanical characteristics, traditional and contemporary uses, pharmacognosy, phytochemical constituents, pharmacology, agriculture, and miscellaneous aspects. Ethnobotanical reports, wet laboratory experiments, pharmacognostic characteristics, phytoconstituents, and pharmacology (experimental works and clinical trials) are selected to include in this review. Evidence-based papers from indexed sources were also considered. Results and discussion: Asparagus adscendens has been used for the treatment of chronic leucorrhea, spermatorrhea, general weakness, diarrhea, dysentery, rejuvenation, and aphrodisiacs in Ayurveda by its various names and formulations since 1000 BC, the period of Agnivesa. This plant has great pharmacological actions such as antifertility, antioxidant, anthelminthic, antidiabetic, etc. Conclusion: Musali has been a unique gift of nature to mankind since time immemorial. It is a major ingredient in many Ayurvedic formulations. It has several uses, including as a strong "Rasayana" (rejuvenator), a tonic and vitalizer that promotes health, a therapeutic remedy for prenatal and postnatal problems, a restorative agent that boosts immunity, and a strong aphrodisiac. It will take a number of scientific endeavors to investigate the pharmacological actions that are hidden and described in the classics. To assess the pharmacotherapeutics of Asparagus adscendens and provide a solid, evidence-based treatment, more clinical studies may be carried out.

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“…The lipid structures and in particular the cell membranes are the first targets of the ROS because of their richness in unsaturated fatty acids [ 34 – 36 ]. ROS reactions with membrane lipids concretize in lipid peroxidation processes in cascade.…”

Section: Free Radicals Oxidative Stress and Cancermentioning

confidence: 99%

“…ROS reactions with membrane lipids concretize in lipid peroxidation processes in cascade. Normally, the primary products of lipoperoxidation, the lipid hydroperoxides (LOOH), are detoxified through the enzymatic pathway of glutathione S-transferases (GST); however, when homeostasis is disturbed, the lipoperoxides escaping this detoxification led to toxic aldehydes; the best known of which is malondialdehyde (MDA) a highly reactive and mutagenic dialdehyde; the potential mutagen of MDA was detected in bacterial and mammalian cells [ 36 – 38 ]. MDA forms stable bonds with -NH 2 amine groups of biomolecules (proteins, phospholipids, or nucleic acids) to produce inter- and intramolecular bridges of amino-3-iminopropene and structural modifications, and thus, it diffuses easily and can reach the cellular nucleus.…”

Section: Free Radicals Oxidative Stress and Cancermentioning

confidence: 99%

“…Oxidative Medicine and Cellular Longevity membrane lipids concretize in lipid peroxidation processes in cascade. Normally, the primary products of lipoperoxidation, the lipid hydroperoxides (LOOH), are detoxified through the enzymatic pathway of glutathione S-transferases (GST); however, when homeostasis is disturbed, the lipoperoxides escaping this detoxification led to toxic aldehydes; the best known of which is malondialdehyde (MDA) a highly reactive and mutagenic dialdehyde; the potential mutagen of MDA was detected in bacterial and mammalian cells [36][37][38].…”

Section: Free Radicals Oxidative Stress and Cancermentioning

confidence: 99%

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The Involvement of the Oxidative Stress Status in Cancer Pathology: A Double View on the Role of the Antioxidants

Zahra

Lefter

Ali

et al. 2021

Oxidative Medicine and Cellular Longevity

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Oxygen-free radicals, reactive oxygen species (ROS) or reactive nitrogen species (RNS), are known by their “double-sided” nature in biological systems. The beneficial effects of ROS involve physiological roles as weapons in the arsenal of the immune system (destroying bacteria within phagocytic cells) and role in programmed cell death (apoptosis). On the other hand, the redox imbalance in favor of the prooxidants results in an overproduction of the ROS/RNS leading to oxidative stress. This imbalance can, therefore, be related to oncogenic stimulation. High levels of ROS disrupt cellular processes by nonspecifically attacking proteins, lipids, and DNA. It appears that DNA damage is the key player in cancer initiation and the formation of 8-OH-G, a potential biomarker for carcinogenesis. The harmful effect of ROS is neutralized by an antioxidant protection treatment as they convert ROS into less reactive species. However, contradictory epidemiological results show that supplementation above physiological doses recommended for antioxidants and taken over a long period can lead to harmful effects and even increase the risk of cancer. Thus, we are describing here some of the latest updates on the involvement of oxidative stress in cancer pathology and a double view on the role of the antioxidants in this context and how this could be relevant in the management and pathology of cancer.

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Antioxidant Potential of Asparagus adscendens

Cited by 4 publications

References 86 publications

Expression of eIF4E Gene in Glioma and Its Sensitivity to Oxidative Stress

Expression of eIF4E Gene in Glioma and Its Sensitivity to Oxidative Stress

Traditional uses, Phytochemistry and Pharmacology of Asparagus adscendens Roxb.: A Review

The Involvement of the Oxidative Stress Status in Cancer Pathology: A Double View on the Role of the Antioxidants

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