Prevention of arthritic inflammation using an oriental herbal combination BDX-1 isolated fromAchyranthes bidentata andAtractylodes japonica

Han, Sang‐Bae; Lee, Chang Woo; Yoon, Yeo Dae; Lee, Jong-Ho; Kang, Jong Soon; Lee, Ki Hoon; Yoon, Won Kee; Lee, Kiho; Park, Song‐Kyu; Kim, Hwan Mook

doi:10.1007/bf02973875

Cited by 38 publications

(23 citation statements)

References 24 publications

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“…Moreover, all SMF four ingredients contain the anti-inflammatory substances, such as berberine and atractylodine, which were confirmed to have anti-inflammatory activity. [50][51][52][53] Thus, we deduce that SMF inhibits inflammation response in OA by interfering with secretion of pro-inflammatory cytokines and inflammatory mediators.…”

Section: Discussionmentioning

confidence: 79%

Treatment with SiMiaoFang, an Anti-Arthritis Chinese Herbal Formula, Inhibits Cartilage Matrix Degradation in Osteoarthritis Rat Model

Liu

et al. 2013

Rejuvenation Research

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A Chinese herbal preparation, SiMiaoFang (SMF), has been used clinically for treating arthralgia by virtue of its anti-inflammatory and pain-relieving activities. However, no evidence base links SMF to anti-osteoarthritis (OA), particularly its link to inhibiting cartilage matrix degradation. In this study, we undertook a characterization of anti-OA activity of SMF using an in vivo rat model induced by anterior cruciate ligament transection and medial meniscus resection (ACLT + MMx) together with in vitro studies with chondrocytes for further molecular characterization. ACLT + MMx rats were treated with SMF at doses of 0.63, 1.25, and 2.5 grams/kg per day for 6 weeks. SMF treatments significantly inhibited cartilage matrix degradation, as indicated by increasing proteoglycan and collagen content, particularly type II collagen expression in articular cartilage, decreasing CTX-II (collagen type II degradation marker), and increasing CPII (collagen type II synthesis marker) in circulation. Moreover, SMF suppressed synovial inflammation and inhibited release of interleukin-1b (IL-1b) and tumor necrosis factor-a in serum. The levels of serum prostaglandin E 2 and nitric oxide productions were decreased via suppression of the production of cyclooxygenase-2 and inducible nitric oxide synthase, respectively. Importantly, SMF interfered with OA-augmented expression of matrix metalloproteinases (MMPs) -3 and -13 and aggrecanases (ADAMTS) -4 and -5, which are considered to be key enzymes in cartilage matrix degradation, and simultaneously augmented OA-reduced tissue inhibitors of metalloproteinases (TIMPs) -1 and -3 expression in the joints. The largest changes in these parameters were found at the highest dose. Meanwhile, SMF significantly decreased MMP-3 and -13 and increased TIMP-1 and -3 at mRNA and protein levels in IL-1b-induced chondrocytes. These findings provide the first evidence that SMF effectively treats OA by inhibiting cartilage matrix degradation.

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Section: Discussionmentioning

confidence: 79%

Treatment with SiMiaoFang, an Anti-Arthritis Chinese Herbal Formula, Inhibits Cartilage Matrix Degradation in Osteoarthritis Rat Model

Liu

et al. 2013

Rejuvenation Research

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“…the treatment of many infl ammatory diseases including atherosclerosis (Han et al, 2005). To fi nd new therapeutic agents for vascular infl ammation in atherosclerosis, we examined several original herbs and found that treatment with EGJ can signifi cantly attenuate monocyte adhesion to TNF-α-stimulated HUVEC by inhibiting the expression of VCAM-1 and E-selectin.…”

Section: Discussionmentioning

confidence: 99%

Gardenia jasminoides inhibits tumor necrosis factor‐alpha‐induced vascular inflammation in endothelial cells

Hwang

Lee

Yoon

et al. 2010

Phytotherapy Research

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Inflammatory mediators such as tumor necrosis factor-alpha (TNF-alpha) enhance binding of low-density lipoprotein to endothelium and upregulate the expression of endothelial leukocyte adhesion molecules during atherogenesis. The present study examined the effect of ethanol extract of Gardenia jasminoides (EGJ) on vascular inflammation in primary cultured human umbilical vein endothelial cells (HUVEC). TNF-alpha-induced the expression of vascular cell adhesion molecule-1 (VCAM-1) and endothelial cell-selectin (E-selectin) expression was inhibited in HUVEC pretreated with EGJ. In a functional study, EGJ dose-dependently attenuated adhesion of HL-60 monocytes to endothelial monolayers. A further analysis indicated that EGJ attenuated TNF-alpha-induced nuclear p65 nuclear factor-kappa B (NF-kappaB) translocation, suggesting that EGJ primarily affects the TNF-alpha-induced NF-kappaB signaling pathway. Taken together, we provided here the first evidence showing that EGJ is able to inhibit TNF-alpha-induced NF-kappaB activation, adhesion molecule expression, and monocyte-endothelial interaction, suggesting an anti-inflammatory role of EGJ, which may be useful in preventing vascular diseases, such as atherosclerosis.

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“…Isolated supernatants were mixed with an equal volume of Griess reagent and then incubated at room temperature for 10 min. Nitrite production was determined by measuring absorbance at 540 nm versus a NaNO 2 -derived standard curve (Han et al, 2005a). Immature DCs (iDC) recovered from these cultures on day 8 were generally >85% CD11c + , but not CD3 + and B220 + .…”

Section: Generation Of Primary Macrophages and Dendritic Cellsmentioning

confidence: 99%

Evaluation of Immunotoxicity of Shizukaol B Isolated from Chloranthus japonicus

Kwon¹,

Kim²,

Kim³

et al. 2011

Biomolecules and Therapeutics

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Prevention of arthritic inflammation using an oriental herbal combination BDX-1 isolated fromAchyranthes bidentata andAtractylodes japonica

Cited by 38 publications

References 24 publications

Treatment with SiMiaoFang, an Anti-Arthritis Chinese Herbal Formula, Inhibits Cartilage Matrix Degradation in Osteoarthritis Rat Model

Treatment with SiMiaoFang, an Anti-Arthritis Chinese Herbal Formula, Inhibits Cartilage Matrix Degradation in Osteoarthritis Rat Model

Gardenia jasminoides inhibits tumor necrosis factor‐alpha‐induced vascular inflammation in endothelial cells

Evaluation of Immunotoxicity of Shizukaol B Isolated from Chloranthus japonicus

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