Prevention of Allergic Sensitization and Treatment of Cow’s Milk Protein Allergy in Early Life: The Middle-East Step-Down Consensus

Vandenplas, Yvan; Alhussaini, Bakr H.; Al-Mannaei, Khaled; Al-Sunaid, Areej; Ayesh, Wafaa; Eldegeir, Manal; El-Kabbany, Nevine; Haddad, Joseph; Hashmi, Aziza; Kreishan, Furat; Tawfik, Eslam

doi:10.3390/nu11071444

Cited by 33 publications

(48 citation statements)

References 40 publications

(50 reference statements)

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“…Обязательным элементом диагностики АБКМ у детей как на искусственном, так и на естественном вскармливании является элиминационная диета длительностью 2-4 нед с последующим диагностическим введением продукта [14]. У детей на искусственном вскармливании при подозрении на АБКМ рекомендован перевод пациента на высокогидролизованные смеси (ВГС) или аминокислотные смеси -как при IgE-зависимых, так и при IgE-независимых формах [15,16]. Стоит помнить о том, что возникновение симптомов после употребления продуктов говорит лишь о наличии причинно-следственной связи, но не обязательно о вовлечении в процесс иммунологических механизмов.…”

Section: клинические проявления аллергии к белкам коровьего молокаunclassified

“…Срок элиминации белков коровьего молока составляет не менее 6 мес или до возраста одного года, при тяжелом течении -увеличивается до 12-18 мес [44]. При развитии симптомов аллергии после диагностического введения смеси на основе белков коровьего молока срок элиминации может быть продлен еще на у 6 мес до формирования толерантно- [15]. На этапе расширения диеты следует провести пробу с ЧГС, а не с цельным белком коровьего молока.…”

Section: высокогидролизованные смесиunclassified

“…На этапе расширения диеты следует провести пробу с ЧГС, а не с цельным белком коровьего молока. В случае развития симптомов ребенка переводят на ВГС с оценкой симптомов и при необходимости возвращаются к аминокислотной смеси [15]. Говоря о преимуществах применения ВГС при лечении детей с АБКМ необходимо упомянуть и о сроках формирования толерантности при использовании различных смесей [59].…”

Section: высокогидролизованные смесиunclassified

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Formula Alternatives for Nutrition Therapy of Children with Cow’s Milk Protein Allergy

Новик

Жданова

Зайцева

et al. 2021

Vopr. sovr. pediatr.

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Well-recognized tactic for the management of formula-fed children with cow’s milk protein allergy (CMPA) is exclusion of whole cow milk protein and its replacement with extensively hydrolyzed or amino acid formula. One of the most topical issue is the choice of therapeutic formula for a child with CMPA. This article presents information about the clinical manifestations of CMPA and describes the principles of nutrition therapy. All the stages of preparation of adapted therapeutic formula are discussed in detail. It has been shown that the choice of therapeutic formula for a child with CMPA depends on the disease clinical manifestations, their severity, and the presence of comorbid conditions. Current requirements for extensively hydrolyzed formula are reduced to limitations in the size of peptides with immunoreactive properties and indicate the need for evidence of the clinical efficacy of such formula in double-blind placebo-controlled studies.

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Section: клинические проявления аллергии к белкам коровьего молокаunclassified

Section: высокогидролизованные смесиunclassified

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Formula Alternatives for Nutrition Therapy of Children with Cow’s Milk Protein Allergy

Новик

Жданова

Зайцева

et al. 2021

Vopr. sovr. pediatr.

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“…Extensively hydrolyzed milk formulas and amino acid formulas are often used to treat CMA in infants [4]. In the Middle East, the use of partial hydrolysates as an intermediate, first step-down from the use of intact cow’s milk formulas before introducing extensively hydrolyzed or amino acid formulas was recently discussed and approved during a consensus meeting [5].…”

Section: Cow’s Milk Allergymentioning

confidence: 99%

The Two Faces of Cow’s Milk and Allergy: Induction of Cow’s Milk Allergy vs. Prevention of Asthma

Neerven

Savelkoul

2019

Nutrients

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Cow’s milk has been consumed by humans for over 5000 years and contributed to a drastic change in lifestyle form nomadic to settled communities. As the composition of cow’s milk is relatively comparable to breast milk, it has for a very long time been used as an alternative to breastfeeding. Today, cow’s milk is typically introduced into the diet of infants around 6 months, except when breastfeeding is not an option. In that case, most often cow’s milk based infant formulas are given. Some children will develop cow’s milk allergy (CMA) during the first year of life. However, epidemiological evidence also suggests that consumption of unprocessed, “raw” cow’s milk is associated with a lowered prevalence of other allergies. This Special Issue of Nutrients on “Cow’s Milk and Allergy” (https://www.mdpi.com/journal/nutrients/special_issues/milk_allergy) is dedicated to these two different sides of cow’s milk and allergy, ranging from epidemiology of CMA, clinical presentation and sensitization patterns, treatment and prevention, effects of milk processing, and current management guidelines for CMA, but also the epidemiological evidence linking cow’s milk to lower asthma prevalence as well as the tolerance-inducing effect of raw cow’s milk in food allergy models. In this editorial, we discuss these issues by highlighting the contributions in this Special Issue.

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“…The risk of developing an allergy has become a significant public health issue with increasing prevalence [ 1 ]. The diagnosis of cow’s milk allergy (CMA) can be challenging, since symptoms can be immediate (IgE mediated) as well as delayed (non-IgE mediated), and involve many organ systems.…”

Section: Introductionmentioning

confidence: 99%

How Are Infants Suspected to Have Cow’s Milk Allergy Managed? A Real World Study Report

Vandenplas

Bělohlávková²,

Enninger

et al. 2021

Nutrients

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The purpose of this study was to evaluate the diagnosis and management of infants presenting with symptoms attributable to cow milk allergy (CMA) in a real life setting and to test how the Cow Milk-related Symptom Score (CoMiSS®) can be used to support awareness and diagnosis of cow’s milk protein allergy in primary care practice. The CoMiSS is an awareness tool based on various symptoms such as crying, gastrointestinal symptoms, dermatological and respiratory symptoms. The study was conducted on 268 infants from four countries (Belgium, Czech Republic, Germany, UK) aged 0 to 18 months consulting for CMA related symptoms. The analysis was based on two visits of these subjects. The results show an average CoMiSS of 11 at the first visit. After a therapeutic dietary intervention, the score at the second visit, which happened 3 weeks ± 5 days after the first, dropped to an average value of 4. A satisfaction questionnaire completed by the primary care practitioners suggested an overall high level of satisfaction with the application of the CoMiSS tool in routine practice. These data highlight a huge discrepancy in the diagnosis and management of infants suspected of CMA in the different countries. The findings suggest that the CoMISS questionnaire is an effective tool in aiding awareness of CMPA in primary health care.

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Prevention of Allergic Sensitization and Treatment of Cow’s Milk Protein Allergy in Early Life: The Middle-East Step-Down Consensus

Cited by 33 publications

References 40 publications

Formula Alternatives for Nutrition Therapy of Children with Cow’s Milk Protein Allergy

Formula Alternatives for Nutrition Therapy of Children with Cow’s Milk Protein Allergy

The Two Faces of Cow’s Milk and Allergy: Induction of Cow’s Milk Allergy vs. Prevention of Asthma

How Are Infants Suspected to Have Cow’s Milk Allergy Managed? A Real World Study Report

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