Prevention of aflatoxin B1-initiated hepatotoxicity in rat by marine algae extracts

Abstract

Chemoprevention by extracts of Laurencia obtusa (E1) and Caulerpa prolifera (E2) collected from the Egyptian coast of the Red Sea against aflatoxin B(1) (AFB(1))-initiated hepatotoxicity in female Sprague-Dawley rats has been studied. Animals were fed aflatoxin-contaminated diet (3 mg kg(-1) diet) for 6 days then treated orally with pure aflatoxin B(1) (AFB(1)) (200 microg kg(-1) b.w.) for 4 days either in combination with or before E1 or E2 administration (50 mg kg(-1) b.w.). AFB(1) resulted in a signicant increase in serum alpha fetoprotein, carcinoembryonic antigen, tumor necrosis factor alpha, nitric oxide, interleukin-1alpha, procollagen III and lipid peroxidation level in the liver. It caused a signicant decrease in food intake, body weight, serum leptin, the activities of glutathione peroxidase, superoxide dismutase and DNA and RNA concentrations in the liver. Cotreatment with AFB(1) and E1 or E2 resulted in an obvious improvement in all tested parameters. Noteworthy, E2 was more effective than E1 in the protection against AFB(1)-induced hepatotoxicity.

Investigation of the Biochemical and Histological Changes Induced by Zearalenone Mycotoxin on Liver in Male Mice and the Protective Role of Crude Venom Extracted from Jellyfish <i>Cassiopea Andromeda</i>

“…Normally, no production of this marker occurs in the adult cells, but it can be secreted when these cells transformed to cancer cells. Similar finding was observed by Sell et al [23] and Abdel-Wahhab et al [24] who found that aflatoxins feeding to ducks for longer term and rats for 6 days produced an elevation in the level of serum AFP. Our result may be attributed to estrogen like effect of ZEN, because estrogens can interact with specific receptors called estrogen receptors (ER) in the liver and exerting a number of toxic effects, including liver adenomas and hepatocarcinomas [25,26].…”

Effect of oral supplementation of Lactobacillus reuteri in reduction of intestinal absorption of aflatoxin B1 in rats

“…This effect could be induced by the dose of aflatoxin received, since it has been reported that AFB 1 induces reduction of food intake in some animal species, including rats and birds, in a dose-dependent manner [33]. In addition, toxicological studies in rats have shown that AFB 1 consumption may produce a significant decrease of serum leptin levels [34]. Leptin concentration is usually associated with the high levels of cortisol and interleukin-6, which act together to influence the feeding response [35].…”

THE FIRST SUBSTANTIATED RECORD AND NORTHWARD EXPANSION OF THE MERTENS' PRAWN-GOBY, Vanderhorstia mertensi (OSTEICHTHYES: GOBIIDAE) IN THE AEGEAN SEA

“…It is well documented that CCl 4 enhanced lipid peroxidation (Abdel-Wahhab et al, 2006;El Denshary et al, 2012). The CCl 4 induces the peroxidation of lipids that damage the membranes of liver cells and organelles.…”